Details of Disease

General Information of Disease (ID: DISMCMLQ)

• Disease Name: Peritonitis
• Synonyms: peritoneum inflammation; primary bacterial peritonitis; retractile mesenteritis; acute generalized peritonitis; inflammation of peritoneum; acute generalised peritonitis
• Definition: Inflammation of the peritoneum due to infection by bacteria or fungi. Causes include liver disease, perforation of the gastrointestinal tract or biliary tract, and peritoneal dialysis. Patients usually present with abdominal pain and tenderness, fever, chills, and nausea and vomiting. It is an emergency medical condition that requires prompt medical attention and treatment.
• Disease Hierarchy:
  DIS7JDYJ: Gastrointestinal disease
  DISWD40R: Disease
  DISDR98C: Serositis
  DISMCMLQ: Peritonitis
• Disease Identifiers:
  MONDO ID: MONDO_0004522
  MESH ID: D010538
  UMLS CUI: C0031154
  MedGen ID: 14697
  HPO ID: HP:0002586
  SNOMED CT ID: 48661000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 18 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ampicillin	DMHWE7P	Approved	Small molecular drug	[1]
Aztreonam	DMDNJHG	Approved	Small molecular drug	[2]
Cefamandole	DMNEXZF	Approved	Small molecular drug	[3]
Cefotaxime	DMEB837	Approved	NA	[4]
Cefoxitin	DMY8NC4	Approved	NA	[5]
Ceftazidime	DM41GRA	Approved	Small molecular drug	[6]
Ceftizoxime	DM3VOGS	Approved	Small molecular drug	[7]
Cilastatin	DME2H5T	Approved	Small molecular drug	[8]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[9]
Gentamicin	DMKINJO	Approved	Small molecular drug	[10]
Imipenem	DMI9FBP	Approved	Small molecular drug	[8]
Meropenem	DM62UHC	Approved	Small molecular drug	[11]
Metronidazole	DMTIVEN	Approved	Small molecular drug	[12]
Moxifloxacin	DMU8V4S	Approved	Small molecular drug	[13]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[14]
Piperacillin	DMTBKF3	Approved	Small molecular drug	[15]
Tazobactam	DM3XNUI	Approved	Small molecular drug	[16]
Tobramycin	DMUI0CH	Approved	Small molecular drug	[17]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
C5	TTKANGO	Strong	Biomarker	[18]
GSK3B	TTRSMW9	Strong	Biomarker	[19]

References

• [1] Ampicillin FDA Label
• [2] Aztreonam FDA Label
• [3] Cefamandole FDA Label
• [4] Cefotaxime FDA Label
• [5] Cefoxitin FDA Label
• [6] Ceftazidime FDA Label
• [7] Ceftizoxime FDA Label
• [8] Cilastatin FDA Label
• [9] An experimental evaluation of the pharmacokinetics of fusidic acid in peritoneal dialysis. J Med Microbiol. 1992 Feb;36(2):71-7.
• [10] Gentamicin FDA Label
• [11] Meropenem FDA Label
• [12] Metronidazole FDA Label
• [13] Moxifloxacin FDA Label
• [14] Norfloxacin FDA Label
• [15] Piperacillin FDA Label
• [16] Tazobactam FDA Label
• [17] Tobramycin FDA Label
• [18] Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.
• [19] IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.Immunity. 2006 May;24(5):563-74. doi: 10.1016/j.immuni.2006.02.014.