Details of Disease

General Information of Disease (ID: DISN8K9H)

Disease Name Traumatic brain injury
Disease Class NA07: Intracranial injury
Definition A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head.
Disease Hierarchy
DISZI5OZ: Brain injury
DISN8K9H: Traumatic brain injury
ICD Code
ICD-11
ICD-11: NA07.Z
Expand ICD-11
'NA07.Z
Expand ICD-9
8.01E+26

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 14 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Armodafinil DMGB035 Approved Small molecular drug [1]
Chloral hydrate DMEOSTQ Approved Small molecular drug [2]
Dexmedetomidine DM93L4X Approved Small molecular drug [3]
Duloxetine DM9BI7M Approved Small molecular drug [4]
Fentanyl DM8WAHT Approved Small molecular drug [5]
Galantamine DMEO794 Approved Small molecular drug [6]
Ketamine DMT5HA4 Approved Small molecular drug [7]
Magnesium Sulfate DMVEK07 Approved Small molecular drug [8]
Methylphenidate DM7SJD6 Approved Small molecular drug [9]
Midazolam DMXOELT Approved Small molecular drug [10]
Modafinil DMYILBE Approved Small molecular drug [11]
Propofol DMB4OLE Approved Small molecular drug [12]
Trofinetide DMPZ97S Approved Small molecular drug [13]
Ziconotide DMSLJP4 Approved Small molecular drug [14]
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⏷ Show the Full List of 14 Drug(s)
This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dexanabinol DMRH291 Phase 3 Small molecular drug [15]
Anatibant DMG7IEN Phase 2 Small molecular drug [16]
CEVA101 DMAQUAG Phase 2 Cell therapy [17]
SB-623 DM4NY58 Phase 2 Small molecular drug [13]
SB623 DMCXTM0 Phase 2 Cell therapy [18]
VOLT02 DM1YCC2 Phase 2 NA [13]
SAR127963 DMWX1M0 Phase 1 NA [19]
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Oxycyte DMOYLOT Preclinical Small molecular drug [20]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Erythropoietin DM3R8YL Investigative NA [21]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1 Armodafinil FDA Label
2 Anesthesia for euthanasia influences mRNA expression in healthy mice and after traumatic brain injury. J Neurotrauma. 2014 Oct 1;31(19):1664-71.
3 Dexmedetomidine FDA Label
4 Duloxetine FDA Label
5 Fentanyl FDA Label
6 Galantamine FDA Label
7 Ketamine FDA Label
8 Magnesium Sulfate FDA Label
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7236).
10 Midazolam FDA Label
11 Modafinil FDA Label
12 Propofol FDA Label
13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
14 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2536).
15 Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84.
16 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 679).
17 Clinical pipeline report, company report or official report of Cellvation.
18 ClinicalTrials.gov (NCT02416492) A Study of Modified Stem Cells in Traumatic Brain Injury (TBI) (STEMTRA). U.S. National Institutes of Health.
19 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035960)
20 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016741)
21 Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Front Aging Neurosci. 2022 Aug 1;14:901117.