Details of Disease

General Information of Disease (ID: DISQ7EAD)

Disease Name Anterior uveitis
Synonyms iridocyclitis; anterior uveitis; anterior uveitis (disease)
Disease Class 9A96: Anterior uveitis
Definition Inflammation of the iris and anterior chamber of the eye.
Disease Hierarchy
DISV0RYS: Uveitis
DISQ7EAD: Anterior uveitis
ICD Code
ICD-11
ICD-11: 9A96
Expand ICD-11
'9A96
Expand ICD-10
'H20.0; 'H20.1; 'H20.2; 'H20.8; 'H20.9; 'H22.1
Disease Identifiers
MONDO ID
MONDO_0006651
UMLS CUI
C0042165
MedGen ID
22595
HPO ID
HP:0012122
Orphanet ID
280886
SNOMED CT ID
410692006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Sivelestat DM6BZCV Phase 3 Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 9 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
HLA-B TTGS10J Limited Genetic Variation [2]
IL23R TT6H4QR Limited Genetic Variation [3]
C3 TTJGY7A Strong Biomarker [4]
CCL3 TT8I4WB Strong Biomarker [5]
CCR1 TTC24WT Strong Biomarker [6]
CCR5 TTJIH8Q Strong Biomarker [7]
CD59 TTBGTEJ Strong Biomarker [4]
ERAP1 TT60XFL Strong Genetic Variation [3]
IL19 TT87RWS Strong Genetic Variation [3]
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⏷ Show the Full List of 9 DTT(s)
This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
C4A OTXMOYXU Strong Biomarker [8]
IL6R OTCQL07Z Strong Genetic Variation [3]
INAVA OTGXNB86 Strong Genetic Variation [3]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Characterization and outcome of uveitis in 350 patients with spondyloarthropathies.Rheumatol Int. 2006 Oct;26(12):1143-6. doi: 10.1007/s00296-006-0203-7. Epub 2006 Sep 7.
3 Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis.Arthritis Rheumatol. 2015 Jan;67(1):140-51. doi: 10.1002/art.38873.
4 Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU).J Immunol. 2006 Jun 15;176(12):7221-31. doi: 10.4049/jimmunol.176.12.7221.
5 Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats.J Autoimmun. 2002 Jun;18(4):259-70. doi: 10.1006/jaut.2002.0591.
6 Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE.Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2894-903.
7 Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis.Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1339-47. doi: 10.1167/iovs.04-0640.
8 Association of complement allotype C4B2 with anterior uveitis.Hum Immunol. 1988 Apr;21(4):233-7. doi: 10.1016/0198-8859(88)90032-8.