Details of Disease

General Information of Disease (ID: DISV0RYS)

Disease Name	Uveitis
Synonyms	uveitis; uvea inflammation; uveitis (disease); inflammation of uvea
Disease Class	9A96: Anterior uveitis
Definition	An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision.
Disease Hierarchy	DISHRZOY: Uveal disorder DIS184KT: Skin inflammation DISWD40R: Disease DISV0RYS: Uveitis
ICD Code	ICD-11 ICD-11: 9A96.Z ICD-9 ICD-9: 364 Expand ICD-11 '9A96.Z Expand ICD-9 364
Disease Identifiers	MONDO ID MONDO_0020283 MESH ID D014605 UMLS CUI C0042164 MedGen ID 52961 HPO ID HP:0000554 Orphanet ID 98715 SNOMED CT ID 128473001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 14 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[1]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[2]
Dromostanolone	DMF2JDG	Approved	Small molecular drug	[3]
Fluorometholone	DM2HKC4	Approved	Small molecular drug	[4]
Framycetin	DMF8DNE	Approved	Small molecular drug	[5]
Homatropine Methylbromide	DMGBPSH	Approved	Small molecular drug	[6]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[7]
Medrysone	DMJ90O5	Approved	Small molecular drug	[8]
Polymyxin B Sulfate	DMN0LP8	Approved	Small molecular drug	[9]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[10]
Rimexolone	DMTAREC	Approved	Small molecular drug	[11]
Scopolamine	DMOM8AL	Approved	Small molecular drug	[12]
Sirolimus	DMGW1ID	Approved	Small molecular drug	[13]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[14]
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⏷ Show the Full List of 14 Drug(s)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
B27PD	DMPLT0I	Phase 1/2	NA	[15]
Optiquel	DM5JJMF	Phase 1	NA	[16]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LPO-1010UV	DM3PSKW	Investigative	NA	[17]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 40 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FASLG	TTO7014	Limited	Biomarker	[18]
HLA-DRB1	TTUXSTW	Limited	Genetic Variation	[19]
ALB	TTFNGC9	moderate	Biomarker	[20]
IL17A	TTG0MT6	moderate	Biomarker	[21]
IL1A	TTPM6HI	moderate	Biomarker	[22]
NLRP3	TT4EN8X	moderate	Biomarker	[23]
SERPINF1	TTR59S1	moderate	Altered Expression	[24]
AIF1	TT12MEP	Strong	Altered Expression	[25]
AMD1	TTBFROQ	Strong	Biomarker	[26]
ANXA1	TTUCK4B	Strong	Biomarker	[27]
AOC3	TT7HC21	Strong	Biomarker	[28]
AQP1	TTSF1KH	Strong	Biomarker	[29]
ARG1	TT7ZQEV	Strong	Biomarker	[30]
C3AR1	TTI6B3F	Strong	Altered Expression	[31]
CCL5	TT9DWLC	Strong	Biomarker	[32]
CCR5	TTJIH8Q	Strong	Biomarker	[32]
CFI	TT6ATLX	Strong	Biomarker	[33]
CRYAA	TT8CWJG	Strong	Biomarker	[34]
CX3CL1	TT1OFBQ	Strong	Altered Expression	[35]
CX3CR1	TT2T98G	Strong	Biomarker	[36]
CXCL10	TTQOVYA	Strong	Biomarker	[37]
ERAP1	TT60XFL	Strong	Biomarker	[38]
ERAP2	TTVGS1C	Strong	Biomarker	[38]
HLA-DQA1	TTU2I3J	Strong	Genetic Variation	[39]
HSPA9	TTMTPG3	Strong	Biomarker	[34]
ICAM1	TTA1L39	Strong	Altered Expression	[40]
ICOS	TTE5VP6	Strong	Biomarker	[41]
IL17D	TTC5LTG	Strong	Altered Expression	[42]
IL18	TTRICUF	Strong	Biomarker	[43]
IL1RAP	TTWS50K	Strong	Biomarker	[44]
IL23R	TT6H4QR	Strong	Genetic Variation	[45]
KCNJ10	TTG140O	Strong	Biomarker	[46]
MOG	TTQAFX5	Strong	Biomarker	[47]
NR3C1	TTOZRK6	Strong	Biomarker	[48]
RTN4R	TTVRZUO	Strong	Altered Expression	[49]
S100A12	TTQ4ESF	Strong	Altered Expression	[19]
TICAM1	TT2GQT6	Strong	Biomarker	[50]
TLR4	TTISGCA	Strong	Biomarker	[51]
TNFRSF1A	TTG043C	Strong	Biomarker	[52]
VIP	TTGTWLF	Strong	Biomarker	[53]
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⏷ Show the Full List of 40 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ANXA11	DTGQ2CF	Strong	Genetic Variation	[54]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP27B1	DE3FYEM	Strong	Biomarker	[55]
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This Disease Is Related to 45 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AIMP1	OTTA5C3U	Limited	Biomarker	[56]
CAPN5	OTQ8QM7K	Limited	Genetic Variation	[57]
DBP	OTE0W7LN	Limited	Genetic Variation	[58]
KNTC1	OTI2OOFN	Limited	Biomarker	[59]
PFDN5	OTTKPTUP	Limited	Biomarker	[60]
TRAF5	OTSBTLO0	Limited	Genetic Variation	[61]
ADO	OTRLGQ7V	Strong	Genetic Variation	[45]
AIRE	OTA7G1Y1	Strong	Genetic Variation	[62]
AQP4	OTA9MYD5	Strong	Biomarker	[63]
ARIH1	OTO3XDR2	Strong	Biomarker	[64]
ASS1	OT4ZMG0Q	Strong	Biomarker	[65]
C1orf141	OTASPHL0	Strong	Genetic Variation	[45]
CALB2	OTSNMCG9	Strong	Biomarker	[66]
CCL13	OTNX0JD0	Strong	Altered Expression	[67]
CKB	OTUCKOTT	Strong	Biomarker	[68]
CRYBB2	OTL0Z8E6	Strong	Biomarker	[34]
DPYSL5	OT6F9T6F	Strong	Genetic Variation	[69]
ESD	OTUSIBPS	Strong	Biomarker	[68]
EXTL3	OT2BRUBN	Strong	Biomarker	[70]
GEMIN2	OT4L6TLL	Strong	Biomarker	[71]
HLA-DQB1	OTVVI3UI	Strong	Genetic Variation	[39]
HSPA1L	OTC2V1K6	Strong	Genetic Variation	[72]
IFNL2	OT4BMJF7	Strong	Biomarker	[73]
IL27	OTIS3OF8	Strong	Altered Expression	[42]
KIR3DL1	OTPOSXFX	Strong	Biomarker	[74]
MAP6	OTPUI00F	Strong	Biomarker	[75]
MICA	OTPEIEAR	Strong	Genetic Variation	[76]
MRAP	OTLBWM7X	Strong	Biomarker	[77]
ND4	OT4RQVAA	Strong	Biomarker	[78]
OVGP1	OTL2W9M5	Strong	Biomarker	[79]
PTPRF	OTH5KF2D	Strong	Altered Expression	[49]
RBP3	OTIWM4GT	Strong	Biomarker	[80]
RELA	OTUJP9CN	Strong	Biomarker	[81]
RLBP1	OTCY4D6B	Strong	Biomarker	[82]
RPE	OT0XT3JU	Strong	Biomarker	[83]
SAG	OTDNS3ZQ	Strong	Biomarker	[84]
SCAF11	OTX59D0X	Strong	Biomarker	[71]
SNCB	OTELSEK6	Strong	Biomarker	[85]
SOCS5	OTN1ABYR	Strong	Altered Expression	[86]
SUMO4	OT9B447E	Strong	Genetic Variation	[45]
TJP1	OTBDCUPK	Strong	Biomarker	[87]
TLR10	OTQ1KVJO	Strong	Genetic Variation	[88]
TRIB2	OTHSX3MX	Strong	Biomarker	[89]
TRIM69	OTTEGTRD	Strong	Biomarker	[50]
RBM45	OTWTHD77	Definitive	Biomarker	[90]
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⏷ Show the Full List of 45 DOT(s)

References

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51	Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro.Mediators Inflamm. 2018 Oct 29;2018:2574067. doi: 10.1155/2018/2574067. eCollection 2018.
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