Details of Disease

General Information of Disease (ID: DISQ7OZ9)

• Disease Name: Hyperuricaemia
• Synonyms: uricacidemia; obsolete hyperuricemia (disease); hyperuricemia; blood urate raized
• Disease Class: 5C55: Inborn purine/pyrimidine/nucleotide metabolism error
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISQ7OZ9: Hyperuricaemia
• ICD Code: ICD-11: ICD-11: 5C55.Y

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Allopurinol	DMLPAOB	Approved	Small molecular drug	[1]
Febuxostat	DMDEXQ0	Approved	Small molecular drug	[2]
Lesinurad	DMUR64T	Approved	Small molecular drug	[3]
Probenecid	DMMFWOJ	Approved	Small molecular drug	[4]
Rasburicase	DMAXT7T	Approved	NA	[5]

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FK-505	DMGROQP	Phase 2	Small molecular drug	[6]
RDEA3170	DM1TKG4	Phase 2	NA	[7]
Tofisopam	DMTGNWU	Phase 2	Small molecular drug	[8]

This Disease is Treated as An Indication in 5 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AA-193	DMB5TH3	Discontinued in Phase 2	Small molecular drug	[9]
Doqualast	DMFDHZO	Discontinued in Phase 2	Small molecular drug	[10]
E-5050	DMEVYUW	Discontinued in Phase 2	Small molecular drug	[11]
Irtemazole	DMVI7F8	Discontinued in Phase 2	Small molecular drug	[12]
JTT-552	DMKFIN4	Discontinued in Phase 2	NA	[13]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
KP-624	DMDNXHM	Investigative	NA	[14]
NC-2500	DM45MGZ	Investigative	NA	[15]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6795).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6817).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7673).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4357).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7467).
• [6] X-Ray Powder Diffraction Study on the Grinding Effect of the Polymorphs of a Novel and Orally Effective Uricosuric Agent: FR76505. Volume 20, Issue 18, 1994.
• [7] ClinicalTrials.gov (NCT02078219) Phase II Dose Finding Study of RDEA3170 Versus Placebo in Japanese Patients With Gout or Asymptomatic Hyperuricemia. U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT01519687) Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout. U.S. National Institutes of Health.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003058)
• [10] Effects of the new antiallergic drug 11-oxo-11H-pyrido[2,1-b] quinazoline-2-carboxylic acid on immediate allergic reactions. Arzneimittelforschung. 1986 Nov;36(11):1609-18.
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002294)
• [12] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000965)
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025356)
• [14] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2646).