Details of Disease | DrugMAP

General Information of Disease (ID: DISQEWIW)

Disease Name	Exfoliative dermatitis
Synonyms	exfoliative Dermatitides; erythroderma; Erythrodermas; Dermatitides, exfoliative; dermatitis exfoliativa; exfoliative dermatitis
Definition	The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)
Disease Hierarchy	DISY5SZC: Dermatitis DISQEWIW: Exfoliative dermatitis
Disease Identifiers	MONDO ID MONDO_0043233 MESH ID D003873 UMLS CUI C0011606 MedGen ID 3767 HPO ID HP:0001019 SNOMED CT ID 200948000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALOX12B	TTQ4QQH	Limited	Genetic Variation	[1]
KLK5	TTULSEW	Strong	Biomarker	[2]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DSG1	OT11HC3A	Limited	Genetic Variation	[3]
KRT1	OTIOJWA4	Limited	Genetic Variation	[4]
KRT10	OTSVRD3Q	Limited	Biomarker	[4]
CERS3	OTKCEPYQ	moderate	Genetic Variation	[5]
ABHD5	OTY829Z3	Strong	Genetic Variation	[6]
IVL	OT4VPNGY	Strong	Biomarker	[7]
RAG1	OTV131E4	Strong	Genetic Variation	[8]
TSPYL2	OTGGW2EF	Strong	Genetic Variation	[9]
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⏷ Show the Full List of 8 DOT(s)

References

1	Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.Arch Dermatol. 2008 Mar;144(3):351-6. doi: 10.1001/archderm.144.3.351.
2	Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.J Exp Med. 2014 Mar 10;211(3):499-513. doi: 10.1084/jem.20131797. Epub 2014 Feb 17.
3	Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions.Acta Derm Venereol. 2019 Jul 1;99(9):789-796. doi: 10.2340/00015555-3203.
4	Epidermolytic hyperkeratosis with polycyclic psoriasiform plaques resulting from a mutation in the keratin 1 gene.Exp Dermatol. 1999 Dec;8(6):501-3. doi: 10.1111/j.1600-0625.1999.tb00309.x.
5	Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. J Invest Dermatol. 2013 Sep;133(9):2202-11. doi: 10.1038/jid.2013.153. Epub 2013 Apr 2.
6	Chanarin Dorfman syndrome: a case report with novel nonsense mutation.Gene. 2016 Jan 10;575(2 Pt 1):359-62. doi: 10.1016/j.gene.2015.09.004. Epub 2015 Sep 6.
7	Flow-cytometric investigation of epidermal cell characteristics in monogenic disorders of keratinization and their modulation by topical calcipotriol treatment.Acta Derm Venereol. 1996 Mar;76(2):97-101. doi: 10.2340/000155557697101.
8	GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes.Clin Immunol. 2007 Aug;124(2):165-9. doi: 10.1016/j.clim.2007.04.013. Epub 2007 Jun 14.
9	Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion.Blood. 1997 Jan 1;89(1):32-40.