Details of Disease

General Information of Disease (ID: DISY5SZC)

Disease Name Dermatitis
Synonyms zone of skin inflammation; skin inflammation; inflammatory skin disease; inflammation of zone of skin; inflammation of the skin; inflammation of skin
Disease Class EA80-EA89: Eczema
Definition An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis.
Disease Hierarchy
DISWD40R: Disease
DIS9YPUQ: Dermatological disease
DIS184KT: Skin inflammation
DISY5SZC: Dermatitis
ICD Code
ICD-11
ICD-11: EA80-EA89
ICD-9
ICD-9: 692.9
Expand ICD-11
'EA8Z
Expand ICD-10
'L20-L30; 'L20.9; 'L27; 'L27.2; 'L27.8; 'L27.9; 'L30; 'L30.9
Expand ICD-9
692.9
Disease Identifiers
MONDO ID
MONDO_0002406
MESH ID
D003872
UMLS CUI
C3875321
MedGen ID
849741
HPO ID
HP:0011123
SNOMED CT ID
703938007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Bufexamac DM2UZL9 Approved Small molecular drug [1]
Undecylenic acid DM6644Z Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
APN-201 DMV7Q6X Phase 1/2 NA [3]
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This Disease is Treated as An Indication in 5 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ETH615 DMEGMA2 Discontinued in Phase 2 Small molecular drug [4]
NM-135 DMVH3I7 Discontinued in Phase 2 NA [5]
VM-301 DM42GDO Discontinued in Phase 2 NA [6]
DuP-630 DM7YORJ Terminated NA [7]
PIC-060 DMDFE5M Terminated NA [8]
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This Disease is Treated as An Indication in 7 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
6-Formylindolo[3,2-b]carbazole DMN84RM Investigative Small molecular drug [9]
AIK33 DMZK6T8 Investigative NA [10]
BF/PC-13 DMSBEKJ Investigative NA [10]
KAR-1880 DMXAK75 Investigative NA [11]
NCX-1047 DM1FOSP Investigative NA [12]
NPS-3 DMEKTOK Investigative NA [10]
NPS-4 DMSA1LD Investigative NA [10]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 43 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
DEFB4A TTIVY12 Limited Biomarker [13]
FDFT1 TTFQEO5 Limited Genetic Variation [14]
KLK5 TTULSEW Limited Biomarker [15]
KLK6 TTLPF4X Limited Biomarker [16]
TNFRSF12A TTKPS7V Limited Biomarker [17]
TRPA1 TTELV3W Limited Biomarker [18]
IL22 TTLDX4N moderate Biomarker [19]
CAMP TTULOB6 Strong Biomarker [15]
CCL17 TTMPHAE Strong Biomarker [20]
CCL20 TT2XAZY Strong Altered Expression [21]
CCL22 TTBTWI1 Strong Biomarker [20]
CCR3 TTD3XFU Strong Biomarker [22]
CD160 TTOFEAS Strong Biomarker [23]
CD1A TTBGTFN Strong Biomarker [24]
CLEC4C TT7YT06 Strong Biomarker [25]
CRLF2 TTRMZ0N Strong Biomarker [26]
FAT1 TTGUJYV Strong Biomarker [27]
FFAR2 TT0FYAN Strong Biomarker [28]
FGF7 TTFY134 Strong Biomarker [29]
GALR2 TTBPW3J Strong Biomarker [30]
GPER1 TTDSB34 Strong Biomarker [31]
GRB2 TTEYRJ9 Strong Biomarker [32]
HCAR2 TTWNV8U Strong Biomarker [33]
IFNAR2 TTMQB37 Strong Biomarker [34]
IL15RA TTGN89I Strong Biomarker [35]
IL19 TT87RWS Strong Biomarker [36]
IL1R1 TTWOTEA Strong Genetic Variation [37]
IL1RL2 TTUS18T Strong Biomarker [38]
IL23A TTC1GLB Strong Biomarker [39]
IL25 TTVMO5W Strong Biomarker [40]
IL31 TT1RJXK Strong Biomarker [41]
IL33 TT5MD4P Strong Biomarker [42]
IL37 TTQTX98 Strong Biomarker [43]
IL5 TTPREZD Strong Biomarker [44]
IL7R TTAWI51 Strong Genetic Variation [45]
ITGAE TTH0Z37 Strong Biomarker [46]
KLK8 TTH5MRS Strong Biomarker [47]
MAP3K11 TTETX6Q Strong Altered Expression [48]
PBK TTMY6BZ Strong Biomarker [49]
PREP TTNGKET Strong Biomarker [50]
PTPN6 TT369M5 Strong Genetic Variation [51]
TSLP TTHMW3T Strong Biomarker [52]
IL24 TT1EPXZ Definitive Biomarker [53]
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⏷ Show the Full List of 43 DTT(s)
This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
TGM3 DEOEB3Q Strong Biomarker [54]
UBASH3B DE10BJ5 Strong Biomarker [55]
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This Disease Is Related to 61 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADAMDEC1 OTMT7ZMG Limited Biomarker [56]
ACKR2 OTWYY14H Strong Biomarker [57]
AP1S3 OTPCMV24 Strong Biomarker [58]
AP2A1 OTEFZB21 Strong Altered Expression [47]
ARSH OTG0X9UQ Strong Biomarker [32]
BCL11B OT8KKCVJ Strong Biomarker [59]
C5AR2 OTP1Q82J Strong Biomarker [60]
CASP14 OTKY93H9 Strong Biomarker [61]
CCL26 OT2B7HR9 Strong Altered Expression [22]
CCL27 OTUZYC61 Strong Altered Expression [62]
CCR10 OT7ZWSSD Strong Biomarker [63]
CD109 OTDADBM4 Strong Biomarker [64]
CD1B OT4D5EG7 Strong Biomarker [65]
CD207 OTI9RUDN Strong Biomarker [66]
CD300LF OTQWJGSR Strong Biomarker [67]
CETN1 OTGQ8JOZ Strong Genetic Variation [68]
COL17A1 OTID5AH2 Strong Biomarker [69]
CTNND1 OTUMPSHR Strong Biomarker [70]
DLX3 OTARP5SQ Strong Biomarker [71]
EIF2B5 OTV3R4RB Strong Biomarker [72]
ELOVL6 OTB26UJJ Strong Altered Expression [73]
FLG OTE9QDV6 Strong Genetic Variation [74]
FUT7 OTJF6BSN Strong Genetic Variation [75]
GDF11 OTOSNMND Strong Biomarker [76]
IL17C OTKXIVNQ Strong Biomarker [77]
IL17RD OTKD9XST Strong Biomarker [78]
IL1F10 OTJAASGC Strong Biomarker [79]
IL22RA2 OTGOFDCY Strong Biomarker [80]
IL26 OT2WYCW4 Strong Biomarker [81]
IL36RN OT5CO95A Strong Biomarker [82]
IRF2 OTAZRUW3 Strong Biomarker [83]
ITGAX OTOGIMHE Strong Biomarker [84]
KRT10 OTSVRD3Q Strong Altered Expression [47]
LAMA3 OTFME7HT Strong Genetic Variation [85]
LRIG1 OTY5HZN5 Strong Biomarker [86]
LST1 OTUVG424 Strong Genetic Variation [87]
MAVS OTTQ0J64 Strong Biomarker [88]
MPZL3 OTC4LRBU Strong Biomarker [89]
MYDGF OT9HRPL6 Strong Biomarker [90]
NPTN OTAQKSAU Strong Biomarker [91]
OPN5 OTCYGHDA Strong Biomarker [47]
PSTPIP1 OT4PGEAB Strong Altered Expression [92]
RABGEF1 OTWC3Z3R Strong Genetic Variation [37]
RNF31 OT4BZONL Strong Biomarker [93]
RTRAF OTJ6NVMW Strong Biomarker [72]
S100A14 OTVFJJ91 Strong Genetic Variation [68]
S100A7 OTJFVJRF Strong Biomarker [94]
S100A7A OTNM8DCP Strong Genetic Variation [68]
SDF4 OTQ7WFYW Strong Genetic Variation [68]
SHARPIN OTU1J2KH Strong Biomarker [95]
SOD3 OTIOZQAB Strong Biomarker [15]
SPP2 OTX254AR Strong Altered Expression [96]
STIM2 OTYNXAW0 Strong Biomarker [97]
STK10 OTC33Y2F Strong Biomarker [98]
TMEM79 OTEC6EFU Strong Genetic Variation [99]
TRAF3IP2 OTLLZERL Strong Genetic Variation [100]
TRAF5 OTSBTLO0 Strong Biomarker [101]
TSC22D3 OT03UM03 Strong Biomarker [102]
TTC7A OTDHLPQM Strong Biomarker [103]
CARD14 OTADQHOV Definitive Genetic Variation [104]
CXCL17 OTRCEVIZ Definitive Biomarker [105]
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⏷ Show the Full List of 61 DOT(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7498).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT01513278) Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer. U.S. NationalInstitutes of Health.
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006733)
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011462)
6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006087)
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003777)
8 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007177)
9 Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis. J Dermatol Sci. 2018 Jun;90(3):284-294.
10 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2616).
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622).
13 Increased serum human -defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M.Immunobiology. 2012 Apr;217(4):436-45. doi: 10.1016/j.imbio.2011.10.010. Epub 2011 Oct 23.
14 Exclusion of CTSB and FDFT1 as positional and functional candidate genes for keratolytic winter erythema (KWE).J Dermatol Sci. 2012 Jan;65(1):58-62. doi: 10.1016/j.jdermsci.2011.08.008. Epub 2011 Sep 8.
15 Superoxide Dismutase 3 Inhibits LL-37/KLK-5-Mediated Skin Inflammation through Modulation of EGFR and Associated Inflammatory Cascades.J Invest Dermatol. 2020 Mar;140(3):656-665.e8. doi: 10.1016/j.jid.2019.08.434. Epub 2019 Aug 26.
16 A proinflammatory role of KLK6 protease in Netherton syndrome.J Dermatol Sci. 2019 Jul;95(1):28-35. doi: 10.1016/j.jdermsci.2019.06.004. Epub 2019 Jun 16.
17 Experimental atopic dermatitis is dependent on the TWEAK/Fn14 signaling pathway.Clin Exp Immunol. 2020 Jan;199(1):56-67. doi: 10.1111/cei.13373. Epub 2019 Sep 17.
18 Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice.Eur J Pharmacol. 2019 Sep 5;858:172460. doi: 10.1016/j.ejphar.2019.172460. Epub 2019 Jun 20.
19 Prostaglandin E(2) stimulates adaptive IL-22 production and promotes allergic contact dermatitis.J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.
20 Comparison of the Inhibitory Activities of 5,6-Dihydroergosterol Glycoside - and -Anomers on Skin Inflammation.Molecules. 2019 Jan 21;24(2):371. doi: 10.3390/molecules24020371.
21 Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis.J Dermatol Sci. 2017 Oct;88(1):46-56. doi: 10.1016/j.jdermsci.2017.05.018. Epub 2017 Jun 1.
22 The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation.J Dermatol Sci. 2013 Jul;71(1):12-21. doi: 10.1016/j.jdermsci.2013.04.011. Epub 2013 Apr 19.
23 Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation.J Invest Dermatol. 2007 May;127(5):1161-6. doi: 10.1038/sj.jid.5700680. Epub 2007 Jan 11.
24 CD1a on Langerhans cells controls inflammatory skin disease.Nat Immunol. 2016 Oct;17(10):1159-66. doi: 10.1038/ni.3523. Epub 2016 Aug 22.
25 Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.J Exp Med. 2020 Mar 2;217(3):jem.20190811. doi: 10.1084/jem.20190811.
26 Prostaglandin E(2) (PGE(2))-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression.J Allergy Clin Immunol. 2019 Nov;144(5):1265-1273.e9. doi: 10.1016/j.jaci.2019.06.036. Epub 2019 Jul 11.
27 Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin.Biochem Biophys Res Commun. 2018 Jul 7;502(1):1-8. doi: 10.1016/j.bbrc.2018.05.093. Epub 2018 May 25.
28 GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.Cell Signal. 2017 May;33:59-68. doi: 10.1016/j.cellsig.2017.02.014. Epub 2017 Feb 14.
29 FGF-7 facilitates the process of psoriasis by inducing TNF- expression in HaCaT cells.Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063. doi: 10.1093/abbs/gmz095.
30 Lack of Galanin Receptor 3 Alleviates Psoriasis by Altering Vascularization, Immune Cell Infiltration, and CytokineExpression.J Invest Dermatol. 2018 Jan;138(1):199-207. doi: 10.1016/j.jid.2017.08.015. Epub 2017 Aug 24.
31 Corrigendum: The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG.Front Immunol. 2018 Jul 31;9:1732. doi: 10.3389/fimmu.2018.01732. eCollection 2018.
32 Ashwagandha root extract exerts antiinflammatory effects in HaCaT cells by inhibiting the MAPK/NFB pathways and by regulating cytokines.Int J Mol Med. 2018 Jul;42(1):425-434. doi: 10.3892/ijmm.2018.3608. Epub 2018 Apr 2.
33 The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.Front Immunol. 2018 Aug 14;9:1890. doi: 10.3389/fimmu.2018.01890. eCollection 2018.
34 Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.J Invest Dermatol. 2016 Oct;136(10):1990-2002. doi: 10.1016/j.jid.2016.06.608. Epub 2016 Jun 29.
35 Epidermal IL-15R acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.J Exp Med. 2013 Sep 23;210(10):2105-17. doi: 10.1084/jem.20130291. Epub 2013 Sep 9.
36 The Role of Interleukin-19 in Contact Hypersensitivity.Biol Pharm Bull. 2018;41(2):182-189. doi: 10.1248/bpb.b17-00594.
37 Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.J Clin Invest. 2016 Dec 1;126(12):4497-4515. doi: 10.1172/JCI86359. Epub 2016 Nov 7.
38 IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.Exp Dermatol. 2019 Feb;28(2):113-120. doi: 10.1111/exd.13841. Epub 2018 Dec 21.
39 Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation.J Allergy Clin Immunol. 2020 Jan;145(1):199-214.e11. doi: 10.1016/j.jaci.2019.09.025. Epub 2019 Oct 9.
40 IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.J Invest Dermatol. 2019 Aug;139(8):1732-1742.e17. doi: 10.1016/j.jid.2019.01.021. Epub 2019 Feb 6.
41 IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity.Sci Rep. 2018 Apr 27;8(1):6639. doi: 10.1038/s41598-018-25094-4.
42 Increased Type 2 Innate Lymphoid Cells inPatients with Drug Reaction with Eosinophiliaand Systemic Symptoms Syndrome.J Invest Dermatol. 2019 Aug;139(8):1722-1731. doi: 10.1016/j.jid.2018.10.048. Epub 2019 Feb 5.
43 Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.Planta Med. 2018 Oct;84(15):1110-1117. doi: 10.1055/a-0622-8242. Epub 2018 May 15.
44 IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.J Immunol. 2017 Jul 15;199(2):707-717. doi: 10.4049/jimmunol.1602185. Epub 2017 Jun 14.
45 Opposing roles of endothelial and leukocyte-expressed IL-7R in the regulation of psoriasis-like skin inflammation.Sci Rep. 2019 Aug 12;9(1):11714. doi: 10.1038/s41598-019-48046-y.
46 Integrin E (CD103) is induced but plays no pathogenic role in psoriasiform skin lesions of TGF1 transgenic mice.Exp Dermatol. 2016 Apr;25(4):311-3. doi: 10.1111/exd.12958. Epub 2016 Mar 3.
47 Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin.Br J Dermatol. 2010 Sep;163(3):466-75. doi: 10.1111/j.1365-2133.2010.09864.x. Epub 2010 Aug 12.
48 Downregulation of miR-145-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis.Br J Dermatol. 2019 Feb;180(2):365-372. doi: 10.1111/bjd.17256. Epub 2018 Dec 13.
49 Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.Oncotarget. 2017 Apr 18;8(16):27093-27104. doi: 10.18632/oncotarget.15636.
50 Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.Toxicology. 2010 Oct 29;276(3):192-7. doi: 10.1016/j.tox.2010.08.004. Epub 2010 Aug 13.
51 Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1-Mediated Inflammatory Disease.Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11.
52 Role of bulge epidermal stem cells and TSLP signaling in psoriasis.EMBO Mol Med. 2019 Nov 7;11(11):e10697. doi: 10.15252/emmm.201910697. Epub 2019 Sep 26.
53 IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity.Sci Rep. 2019 Feb 12;9(1):1852. doi: 10.1038/s41598-018-38156-4.
54 Transglutaminase 3 Promotes Skin Inflammation in Atopic Dermatitis by Activating Monocyte-Derived Dendritic Cells via DC-SIGN.J Invest Dermatol. 2020 Feb;140(2):370-379.e8. doi: 10.1016/j.jid.2019.07.703. Epub 2019 Aug 16.
55 Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation.J Pharmacol Sci. 2018 Jan;136(1):9-15. doi: 10.1016/j.jphs.2017.11.002. Epub 2017 Nov 10.
56 ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.Biochem Biophys Res Commun. 2020 Jan 1;521(1):64-71. doi: 10.1016/j.bbrc.2019.10.073. Epub 2019 Oct 16.
57 Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.J Invest Dermatol. 2017 Jan;137(1):85-94. doi: 10.1016/j.jid.2016.07.039. Epub 2016 Aug 26.
58 AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production.J Invest Dermatol. 2016 Nov;136(11):2251-2259. doi: 10.1016/j.jid.2016.06.618. Epub 2016 Jul 5.
59 Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice.PLoS One. 2012;7(12):e51262. doi: 10.1371/journal.pone.0051262. Epub 2012 Dec 20.
60 Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2.Front Immunol. 2018 Mar 15;9:488. doi: 10.3389/fimmu.2018.00488. eCollection 2018.
61 Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.J Dermatol Sci. 2014 Dec;76(3):231-9. doi: 10.1016/j.jdermsci.2014.09.004. Epub 2014 Sep 30.
62 The Skin-Brain Connection Hypothesis, Bringing Together CCL27-Mediated T-Cell Activation in the Skin and Neural Cell Damage in the Adult Brain.Front Immunol. 2017 Jan 16;7:683. doi: 10.3389/fimmu.2016.00683. eCollection 2016.
63 CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.J Allergy Clin Immunol. 2014 Sep;134(3):634-644.e10. doi: 10.1016/j.jaci.2014.03.010. Epub 2014 Apr 24.
64 CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.Genes Cells. 2018 Jul;23(7):590-598. doi: 10.1111/gtc.12593. Epub 2018 May 16.
65 CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice.J Clin Invest. 2017 Jun 1;127(6):2339-2352. doi: 10.1172/JCI92217. Epub 2017 May 2.
66 The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.Cell Microbiol. 2019 Oct;21(10):e13072. doi: 10.1111/cmi.13072. Epub 2019 Jul 8.
67 Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.J Biol Chem. 2017 Feb 17;292(7):2924-2932. doi: 10.1074/jbc.M116.768366. Epub 2017 Jan 10.
68 Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium.Exp Dermatol. 2007 Aug;16(8):685-91. doi: 10.1111/j.1600-0625.2007.00587.x.
69 The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury.Front Immunol. 2018 Mar 1;9:407. doi: 10.3389/fimmu.2018.00407. eCollection 2018.
70 Rho protein GTPases and their interactions with NFB: crossroads of inflammation and matrix biology.Biosci Rep. 2014 Jun 25;34(3):e00115. doi: 10.1042/BSR20140021.
71 Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11566-71. doi: 10.1073/pnas.1019658108. Epub 2011 Jun 27.
72 Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.J Immunol. 2019 Apr 1;202(7):2121-2130. doi: 10.4049/jimmunol.1800650. Epub 2019 Feb 11.
73 Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.Cell Death Dis. 2018 Dec 5;9(12):1181. doi: 10.1038/s41419-018-1226-1.
74 Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1.Allergy. 2019 Oct;74(10):1920-1933. doi: 10.1111/all.13801. Epub 2019 Apr 29.
75 Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.J Immunol. 2016 Oct 15;197(8):3406-3414. doi: 10.4049/jimmunol.1502434. Epub 2016 Sep 2.
76 GDF11 Antagonizes Psoriasis-like Skin Inflammation via Suppression of NF-B Signaling Pathway.Inflammation. 2019 Feb;42(1):319-330. doi: 10.1007/s10753-018-0895-3.
77 IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.J Eur Acad Dermatol Venereol. 2020 Apr;34(4):800-809. doi: 10.1111/jdv.16126. Epub 2020 Jan 19.
78 Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation.Sci Immunol. 2019 Jun 7;4(36):eaau9657. doi: 10.1126/sciimmunol.aau9657.
79 IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from T Cells.Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082.
80 Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation.Front Immunol. 2018 Jun 21;9:1418. doi: 10.3389/fimmu.2018.01418. eCollection 2018.
81 Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis.J Invest Dermatol. 2019 Apr;139(4):878-889. doi: 10.1016/j.jid.2018.09.037. Epub 2018 Nov 10.
82 The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?.Immunol Lett. 2018 Mar;195:30-37. doi: 10.1016/j.imlet.2017.11.012. Epub 2017 Dec 5.
83 IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation.J Dermatol Sci. 2018 Apr;90(1):35-45. doi: 10.1016/j.jdermsci.2017.12.014. Epub 2017 Dec 28.
84 E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis.J Invest Dermatol. 2020 Jan;140(1):132-142.e3. doi: 10.1016/j.jid.2019.06.132. Epub 2019 Jun 28.
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