Details of Disease | DrugMAP

General Information of Disease (ID: DISRIYJ5)

Disease Name	Impulse control disorder
Synonyms	impulse-control disorder; ICD
Definition	A category of behaviors that can be loosely defined as the failure to resist an impulsive act or behavior that may be harmful to self or others.
Disease Hierarchy	DISKFW6V: Psychiatric disorder DISRIYJ5: Impulse control disorder
Disease Identifiers	MONDO ID MONDO_0001162 MESH ID D007174 UMLS CUI C0021122 MedGen ID 5769 SNOMED CT ID 66347000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GRIN2B	TTN9D8E	Strong	Biomarker	[1]
HTR2C	TTWJBZ5	Strong	Altered Expression	[2]
SLC6A8	TTYUHB5	Strong	Genetic Variation	[3]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FLG	OTE9QDV6	Limited	Genetic Variation	[4]
ANKK1	OT0OM1O0	Strong	Biomarker	[5]
FOSB	OTW6C05J	Strong	Biomarker	[6]
MARCHF7	OTG9SF10	Strong	Biomarker	[7]
MCF2L	OTEURA8N	Strong	Biomarker	[8]
PLCD1	OT6WFVXZ	Strong	Biomarker	[9]
SLN	OTERIU75	Strong	Biomarker	[10]
DSCAML1	OT7QURQT	Definitive	Biomarker	[11]
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⏷ Show the Full List of 8 DOT(s)

References

1	Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients.Parkinsonism Relat Disord. 2016 Sep;30:13-7. doi: 10.1016/j.parkreldis.2016.06.005. Epub 2016 Jun 15.
2	Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.Curr Top Med Chem. 2019;19(16):1381-1398. doi: 10.2174/1568026619666190709101449.
3	Implant-based multi-parameter telemonitoring of patients with heart failure and a defibrillator with vs. without cardiac resynchronization therapy option: a subanalysis of the IN-TIME trial.Clin Res Cardiol. 2019 Oct;108(10):1117-1127. doi: 10.1007/s00392-019-01447-5. Epub 2019 Mar 14.
4	Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.Br J Dermatol. 2013 Feb;168(2):326-332. doi: 10.1111/bjd.12083.
5	The addiction-related gene ANKK1 in Parkinsonian patients with impulse control disorder.Neurotox Res. 2015 Apr;27(3):205-8. doi: 10.1007/s12640-014-9504-x. Epub 2014 Dec 2.
6	Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex.Cereb Cortex. 2009 Feb;19(2):435-44. doi: 10.1093/cercor/bhn094. Epub 2008 Jun 6.
7	Dopaminergic Neurotransmission in Patients With Parkinson's Disease and Impulse Control Disorders: A Systematic Review and Meta-Analysis of PET and SPECT Studies.Front Neurol. 2018 Dec 4;9:1018. doi: 10.3389/fneur.2018.01018. eCollection 2018.
8	Measures of impulsivity in Parkinson's disease decrease after DBS in the setting of stable dopamine therapy.Parkinsonism Relat Disord. 2017 Nov;44:13-17. doi: 10.1016/j.parkreldis.2017.08.006. Epub 2017 Aug 9.
9	Epidermal loss of phospholipase C1 attenuates irritant contact dermatitis.Biochem Biophys Res Commun. 2019 Apr 2;511(2):330-335. doi: 10.1016/j.bbrc.2019.02.046. Epub 2019 Feb 18.
10	Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis.Drug Deliv Transl Res. 2017 Feb;7(1):37-52. doi: 10.1007/s13346-016-0350-7.
11	Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.EMBO J. 2019 Mar 15;38(6):e99669. doi: 10.15252/embj.201899669. Epub 2019 Feb 11.