Details of Disease

General Information of Disease (ID: DISRQ76N)

• Disease Name: Liver and intrahepatic bile duct neoplasm
• Synonyms: epithelial hepatic and intrahepatic bile duct neoplasm; tumour of liver; liver neoplasm (disease); hepatic and intrahepatic bile duct neoplasm; tumor of liver; liver tumour; liver tumor; liver and intrahepatic bile duct epithelial neoplasm; liver and intrahepatic bile duct neoplasm; liver neoplasm; neoplasm of liver
• Definition: A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma.
• Disease Hierarchy:
  DISTBY9Z: Tumour
  DISSXKSB: Hepatobiliary neoplasm
  DISGQU9D: Endocrine gland neoplasm
  DIS2OMMF: Liver disease
  DISRQ76N: Liver and intrahepatic bile duct neoplasm
• Disease Identifiers:
  MONDO ID: MONDO_0024477
  UMLS CUI: C1333976
  MedGen ID: 232599

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDKN1A	TT9GUW0	Strong	Biomarker	[1]
KMT5C	TT7H3YM	Strong	ModifyingMutation	[2]
NQO1	TT8XK6L	Strong	Biomarker	[3]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALDOB	OT7FR69A	Strong	Biomarker	[4]
APOBEC1	OTY8QX2R	Strong	Biomarker	[5]
COL1A1	OTI31178	Strong	ModifyingMutation	[6]
H2AX	OT18UX57	Strong	Therapeutic	[7]
HSPA4	OT5HR0AR	Strong	Biomarker	[8]

References

• [1] Immunohistochemical cellular distribution of proteins related to M phase regulation in early proliferative lesions induced by tumor promotion in rat two-stage carcinogenesis models.Exp Toxicol Pathol. 2014 Jan;66(1):1-11. doi: 10.1016/j.etp.2013.07.001. Epub 2013 Jul 23.
• [2] Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.Carcinogenesis. 2006 Jun;27(6):1180-6. doi: 10.1093/carcin/bgi364. Epub 2006 Feb 23.
• [3] Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital.J Toxicol Sci. 2014 Feb;39(1):129-40. doi: 10.2131/jts.39.129.
• [4] Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma.Mol Cell Biochem. 1993 Aug 11;125(1):59-63. doi: 10.1007/BF00926835.
• [5] Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1013-20. doi: 10.1161/01.atv.18.6.1013.
• [6] Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by -naphthoflavone involving TNF-signaling due to oxidative cellular stress in rats.Toxicology. 2011 Apr 28;283(1):8-17. doi: 10.1016/j.tox.2011.01.020. Epub 2011 Feb 2.
• [7] Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model.Exp Toxicol Pathol. 2013 Nov;65(7-8):979-88. doi: 10.1016/j.etp.2013.01.012. Epub 2013 Mar 7.
• [8] Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response.Mol Carcinog. 2013 Apr;52(4):304-17. doi: 10.1002/mc.21860. Epub 2011 Dec 27.