Details of Disease | DrugMAP

General Information of Disease (ID: DISSFU1K)

Disease Name	Systolic heart failure
Definition	Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.
Disease Hierarchy	DIS32MEA: Congestive heart failure DISSFU1K: Systolic heart failure
Disease Identifiers	MONDO ID MONDO_0006993 MESH ID D054143 UMLS CUI C1135191 MedGen ID 210050 SNOMED CT ID 417996009

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NPSR1	TTV1C0Z	Strong	Genetic Variation	[1]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HSPB7	OTLATAOV	Limited	Genetic Variation	[2]
JPH2	OTL9YH7V	Limited	Genetic Variation	[3]
TAB2	OTPZK76F	Limited	Genetic Variation	[4]
FBLN1	OT5MHHOP	Strong	Biomarker	[5]
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References

1	A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.Eur J Heart Fail. 2017 Mar;19(3):314-323. doi: 10.1002/ejhf.706. Epub 2016 Dec 18.
2	Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.J Clin Invest. 2010 Jan;120(1):280-9. doi: 10.1172/JCI39085. Epub 2009 Dec 14.
3	Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure.PLoS One. 2018 Sep 20;13(9):e0203422. doi: 10.1371/journal.pone.0203422. eCollection 2018.
4	6q25.1 (TAB2) microdeletion syndrome: Congenital heart defects and cardiomyopathy.Am J Med Genet A. 2017 Jul;173(7):1848-1857. doi: 10.1002/ajmg.a.38254. Epub 2017 May 2.
5	Galectin-3 and fibulin-1 in systolic heart failure - relation to glucose metabolism and left ventricular contractile reserve.BMC Cardiovasc Disord. 2017 Jan 10;17(1):22. doi: 10.1186/s12872-016-0437-6.