Details of Disease

General Information of Disease (ID: DISTUIM1)

Disease Name	Corneal disease
Synonyms	disorder of cornea; disease or disorder of cornea; disease of cornea; corneal disorder; corneal disease; cornea disease or disorder; cornea disease
Disease Class	9A76-9A78: Corneal disease
Definition	A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Disease Hierarchy	DISWD40R: Disease DISB52BH: Eye disorder DISTUIM1: Corneal disease
ICD Code	ICD-11 ICD-11: 9A78.Z Expand ICD-11 '9A7Z Expand ICD-10 'H15-H22; 'H16.2; 'H16.8; 'H16.9; 'H18.9; 'H19; 'H19.0; 'H19.3
Disease Identifiers	MONDO ID MONDO_0000942 MESH ID D003316 UMLS CUI C0010034 MedGen ID 3617 SNOMED CT ID 15250008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cyclosporin A	DMUYKBZ	Phase 2 Trial	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DE-105	DMZXYNS	Phase 2	NA	[2]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Recombinant NOV	DMHXG9N	Investigative	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDK13	TTRIM0E	moderate	Biomarker	[4]
ITGB6	TTKQSXZ	moderate	Biomarker	[5]
CD86	TT53XHB	Strong	Biomarker	[6]
IGF1	TTT6LOU	Strong	Therapeutic	[7]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC4A11	DTH2J1G	Strong	Biomarker	[8]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KRT12	OTFOWNH2	moderate	Biomarker	[9]
NLRP12	OTGR132Z	moderate	Altered Expression	[10]
OVOL2	OTFM1GKF	moderate	Biomarker	[4]
MXRA7	OTVQLYIY	Strong	Biomarker	[11]
TAC1	OTM842YW	Strong	Therapeutic	[7]
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References

1	Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan;1(1):31-6.
2	ClinicalTrials.gov (NCT00988494) Study of DE-105 Ophthalmic Solution in Patients With Persistent Corneal Epithelial Defect. U.S. National Institutes of Health.
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4	Mutational spectrum of the SLC4A11 gene in autosomal recessive congenital hereditary endothelial dystrophy.Mol Vis. 2007 Jul 26;13:1327-32.
5	Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.Mol Med Rep. 2017 Jan;15(1):139-145. doi: 10.3892/mmr.2016.5984. Epub 2016 Dec 5.
6	Cauterization of central cornea induces recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium.Cornea. 2010 Jan;29(1):73-9. doi: 10.1097/ICO.0b013e3181ac9f92.
7	Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy.Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2937-40. doi: 10.1167/iovs.02-0868.
8	Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.Hum Mol Genet. 2013 Nov 15;22(22):4579-90. doi: 10.1093/hmg/ddt307. Epub 2013 Jun 27.
9	Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study.Exp Eye Res. 2006 Feb;82(2):201-9. doi: 10.1016/j.exer.2005.06.009. Epub 2005 Aug 3.
10	NLRP12 promotes host resistance against Pseudomonas aeruginosa keratitis inflammatory responses through the negative regulation of NF-B signaling.Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8063-8075. doi: 10.26355/eurrev_201812_16496.
11	Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.Gene. 2017 Oct 20;632:43-49. doi: 10.1016/j.gene.2017.08.018. Epub 2017 Aug 26.