Details of Disease

General Information of Disease (ID: DISU51JD)

Disease Name	Premature ejaculation
Synonyms	premature ejaculation (disease); premature ejaculation
Disease Class	HA03: Ejaculatory dysfunction
Definition	A disorder characterized by persistent or recurrent ejaculation before or after penetration and before the person wishes it.
Disease Hierarchy	DISXXLFD: Male sexual disorder DISU51JD: Premature ejaculation
ICD Code	ICD-11 ICD-11: HA03.0Z ICD-10 ICD-10: F52.4 ICD-9 ICD-9: 302.75 Expand ICD-11 'HA03.0 Expand ICD-10 'F52.4 Expand ICD-9 302.75
Disease Identifiers	MONDO ID MONDO_0001780 MESH ID D061686 UMLS CUI C0033038 MedGen ID 452112 HPO ID HP:0012876 SNOMED CT ID 44001008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lidocaine	DML4ZOT	Approved	Small molecular drug	[1]
Prilocaine	DMI7DZ2	Approved	Small molecular drug	[2]
Tramadol	DMRQD04	Approved	Small molecular drug	[3]
Dapoxetine	DMV6KFY	Phase 4	Small molecular drug	[4]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DA-8031	DMP6MH9	Phase 2	NA	[5]
GSK-557296	DM3ZL2O	Phase 2	Small molecular drug	[6]
GSK-958108	DM4LR0Y	Phase 1	NA	[7]
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This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Meluadrine	DMEQDHP	Discontinued in Preregistration	Small molecular drug	[8]
VR-776	DMFQWNI	Discontinued in Phase 1	Small molecular drug	[9]
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This Disease is Treated as An Indication in 3 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aom-0811	DMOVMAG	Investigative	NA	[10]
ARD-412	DM03E28	Investigative	NA	[11]
VI-0134	DM1AO0W	Investigative	NA	[10]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
OXTR	TTSCIUP	Strong	Biomarker	[12]
SLC6A4	TT3ROYC	Strong	Genetic Variation	[13]
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References

1	Lidocaine FDA Label
2	Prilocaine FDA Label
3	Tramadol FDA Label
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7901).
5	ClinicalTrials.gov (NCT01798667) Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation. U.S. National Institutes of Health.
6	ClinicalTrials.gov (NCT01021553) A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation. U.S. National Institutes of Health.
7	ClinicalTrials.gov (NCT00664365) FTIH Study With GSK958108. U.S. National Institutes of Health.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003111)
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022099)
10	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
11	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
12	Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration.ACS Med Chem Lett. 2019 May 29;10(6):996-1001. doi: 10.1021/acsmedchemlett.9b00186. eCollection 2019 Jun 13.
13	Serotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation.Andrology. 2018 Nov;6(6):916-926. doi: 10.1111/andr.12518. Epub 2018 Jul 17.