Details of Disease

Disease Name

Trichinellosis

Human trichinellosis; trichiniasis; infection with Trichinella; Trichinella spiralis infection; trichinosis; Trichinella disease or disorder; Trichinella infectious disease; Trichinella caused disease or disorder

Definition

A zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.

Disease Hierarchy

DISUF82C: Enoplea infectious disease

DISA7NHF: Parasitic myositis

DISEM33Q: Infectious disease

DISUR2ZW: Trichinellosis

Disease Identifiers

MONDO ID

MONDO_0019444

MESH ID

D014235

UMLS CUI

C0040896

MedGen ID

21645

Orphanet ID

863

SNOMED CT ID

709018004

General Information of Disease (ID: DISUR2ZW)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 8 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Betamethasone	DMAHJEF	Approved	Small molecular drug	[1]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[2]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[3]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[4]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[5]
Prednisone	DM2HG4X	Approved	Small molecular drug	[6]
Thiabendazole	DM7YCK3	Approved	Small molecular drug	[7]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[8]
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⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC17A8	DTAGDH7	Strong	Biomarker	[9]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DNASE2	OT6RC1BL	Limited	Biomarker	[10]
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References

1	Betamethasone FDA Label
2	Cortisone acetate FDA Label
3	Dexamethasone FDA Label
4	Hydrocortisone FDA Label
5	Methylprednisolone FDA Label
6	Prednisone FDA Label
7	Thiabendazole FDA Label
8	Triamcinolone FDA Label
9	Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats.Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.
10	Proteomic Analysis of Trichinella spiralis Adult Worm Excretory-Secretory Proteins Recognized by Sera of Patients with Early Trichinellosis.Front Microbiol. 2017 May 31;8:986. doi: 10.3389/fmicb.2017.00986. eCollection 2017.