General Information of Drug (ID: DMAHJEF)

Drug Name
Betamethasone
Synonyms
betamethasone; 378-44-9; Betadexamethasone; Flubenisolone; Betamethazone; Rinderon; Visubeta; Celestene; Betnelan; Betapredol; Betacortril; Betacorlan; Methazon; Betsolan; Betamamallet; Hormezon; Betasolon; Betametasone; Cidoten; Bebate; Bedifos; Becort; beta-Methasone; Desacort-Beta; Rinderon A; beta-Methasone alcohol; Betametasona; Betafluorene; Betamethasonum; Celestone; Betamethasone cream; Betamethasone alcohol; Betametasone [DCIT]; 9alpha-Fluoro-16beta-methylprednisolone; Celestone Syrup and Tablets; Celeston; Celestona; Cellestoderm; Luxiqo; Betamethasone Base; Betamethasone Valearate; Betamethasonvalerat Mikron; LT00441022; SCH 4831; Beta-Methasone; Beta-Methasone alcohol; Betametasona [INN-Spanish]; Betamethasonum [INN-Latin]; Betnovate (TN); Celestone (TN); Diprolene (TN); Diprosone (TN); Lotrisone (TN); Rinderon (TN); SCH-4831; Betamethasone (JP15/USP/INN); Betamethasone [USAN:BAN:INN:JAN]; Betamethasone [USAN:INN:BAN:JAN]; Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone; 1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol; 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-16beta-methylprednisolone; 9-alpha-Fluoro-16-beta-methylprednisolone; 9alpha-Fluoro-16 beta-methyl-prednisolone; Betamethasone sodium phosphate
Indication
Disease Entry ICD 11 Status REF
Acute adrenal insufficiency N.A. Approved [1]
Addison disease 5A74.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Angioedema 4A00.15 Approved [1]
Aspiration pneumonitis N.A. Approved [1]
Autoimmune haemolytic anaemia 3A20 Approved [1]
Bursitis N.A. Approved [1]
Cerebral edema 8D60.1 Approved [1]
Congenital adrenal hyperplasia 5A71.01 Approved [1]
Crohn disease DD70 Approved [1]
Dermatitis herpetiformis EB44 Approved [1]
Diamond-Blackfan anemia N.A. Approved [1]
Disorder of orbital region N.A. Approved [1]
Epicondylitis N.A. Approved [1]
Erythema multiforme N.A. Approved [1]
Exanthem N.A. Approved [1]
Granuloma annulare N.A. Approved [1]
Inflammation 1A00-CA43.1 Approved [2]
Inflammatory bowel disease DD72 Approved [1]
Miliary tuberculosis N.A. Approved [1]
Multiple sclerosis 8A40 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Primary cutaneous T-cell lymphoma N.A. Approved [1]
Psoriasis EA90 Approved [1]
Psoriatic arthritis FA21 Approved [1]
Rheumatic heart disease N.A. Approved [1]
Sarcoidosis 4B20.5 Approved [1]
Scalp dermatosis N.A. Approved [1]
Serum sickness N.A. Approved [1]
Severe asthma CA23 Approved [1]
Skin disease EA00-EM0Z Approved [1]
Systemic lupus erythematosus 4A40.0 Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Acquired thrombocytopenia N.A. Investigative [1]
Asthma CA23 Investigative [1]
Beta-thalassemia major N.A. Investigative [1]
Classic Hodgkin lymphoma N.A. Investigative [1]
Follicular lymphoma 2A80 Investigative [1]
Rheumatoid arthritis FA20 Investigative [1]
Synovitis N.A. Investigative [1]
Tinea pedis 1F28.2 Investigative [1]
Trichinellosis N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 392.5
Logarithm of the Partition Coefficient (xlogp) 1.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The clearance of drug is 6,466 +/- 805 mL/h [4]
Elimination
4.8% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 10.2 +/- 2.5 hours [4]
Metabolism
The drug is metabolized via removal of the side chain [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.38219 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.36% [7]
Vd
The volume of distribution (Vd) of drug is 94.584 +/- 23.539 L [4]
Water Solubility
The ability of drug to dissolve in water is measured as 0.066 mg/mL [3]
Chemical Identifiers
Formula
C22H29FO5
IUPAC Name
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Canonical SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
InChIKey
UREBDLICKHMUKA-DVTGEIKXSA-N
Cross-matching ID
PubChem CID
9782
ChEBI ID
CHEBI:3077
CAS Number
378-44-9
DrugBank ID
DB00443
TTD ID
D0CW1P
VARIDT ID
DR01392
ACDINA ID
D00879
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Agonist [8]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Regulation of Drug Effects [10]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [11]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [11]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [11]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Gene/Protein Processing [12]
Frataxin, mitochondrial (FXN) OTE9U09A FRDA_HUMAN Gene/Protein Processing [13]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Gene/Protein Processing [14]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Gene/Protein Processing [14]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Betamethasone
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Choline salicylate DM8P137 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Choline salicylate. Postoperative inflammation [1A00-CA43] [15]
Ketorolac DMI4EL5 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Ketorolac. Postoperative inflammation [1A00-CA43] [16]
Bromfenac DMKB79O Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Bromfenac. Postoperative inflammation [1A00-CA43] [16]
Coadministration of a Drug Treating the Disease Different from Betamethasone (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Decreased absorption of Betamethasone due to altered gastric pH caused by Sodium bicarbonate. Acidosis [5C73] [17]
Methylphenobarbital DMDSWAG Moderate Increased metabolism of Betamethasone caused by Methylphenobarbital mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [18]
Voriconazole DMAOL2S Moderate Decreased metabolism of Betamethasone caused by Voriconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [19]
Posaconazole DMUL5EW Moderate Decreased metabolism of Betamethasone caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [19]
Levalbuterol DM5YBO1 Minor Increased risk of hypokalemia by the combination of Betamethasone and Levalbuterol. Asthma [CA23] [20]
Terbutaline DMD4381 Minor Increased risk of hypokalemia by the combination of Betamethasone and Terbutaline. Asthma [CA23] [19]
Pirbuterol DMI5678 Minor Increased risk of hypokalemia by the combination of Betamethasone and Pirbuterol. Asthma [CA23] [19]
Salbutamol DMN9CWF Minor Increased risk of hypokalemia by the combination of Betamethasone and Salbutamol. Asthma [CA23] [20]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Betamethasone and Roflumilast. Asthma [CA23] [21]
Formoterol DMSOURV Minor Increased risk of hypokalemia by the combination of Betamethasone and Formoterol. Asthma [CA23] [19]
Ofloxacin DM0VQN3 Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Ofloxacin. Bacterial infection [1A00-1C4Z] [22]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Betamethasone caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [23]
Clarithromycin DM4M1SG Moderate Decreased metabolism of Betamethasone caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [19]
Trovafloxacin DM6AN32 Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Trovafloxacin. Bacterial infection [1A00-1C4Z] [22]
Sparfloxacin DMB4HCT Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Sparfloxacin. Bacterial infection [1A00-1C4Z] [22]
Gemifloxacin DMHT34O Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Gemifloxacin. Bacterial infection [1A00-1C4Z] [22]
Norfloxacin DMIZ6W2 Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Norfloxacin. Bacterial infection [1A00-1C4Z] [22]
ABT-492 DMJFD2I Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and ABT-492. Bacterial infection [1A00-1C4Z] [22]
Levofloxacin DMS60RB Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Levofloxacin. Bacterial infection [1A00-1C4Z] [22]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Betamethasone caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [19]
Lomefloxacin DMVRH9C Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Lomefloxacin. Bacterial infection [1A00-1C4Z] [22]
Telithromycin DMZ4P3A Moderate Decreased metabolism of Betamethasone caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [19]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Betamethasone caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [24]
Tucatinib DMBESUA Moderate Decreased metabolism of Betamethasone caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [19]
Vilanterol DMF5EK1 Minor Increased risk of hypokalemia by the combination of Betamethasone and Vilanterol. Chronic obstructive pulmonary disease [CA22] [20]
Salmeterol DMIEU69 Minor Increased risk of hypokalemia by the combination of Betamethasone and Salmeterol. Chronic obstructive pulmonary disease [CA22] [19]
Indacaterol DMQJHR7 Minor Increased risk of hypokalemia by the combination of Betamethasone and Indacaterol. Chronic obstructive pulmonary disease [CA22] [19]
Arformoterol DMYM974 Minor Increased risk of hypokalemia by the combination of Betamethasone and Arformoterol. Chronic obstructive pulmonary disease [CA22] [19]
Phenylbutazone DMAYL0T Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Phenylbutazone. Chronic pain [MG30] [16]
Isoproterenol DMK7MEY Minor Increased risk of hypokalemia by the combination of Betamethasone and Isoproterenol. Conduction disorder [BC63] [20]
Mivacurium DM473VD Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Mivacurium. Corneal disease [9A76-9A78] [19]
Pancuronium DMB0VY8 Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Pancuronium. Corneal disease [9A76-9A78] [19]
Tubocurarine DMBZIVP Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Tubocurarine. Corneal disease [9A76-9A78] [19]
Mifepristone DMGZQEF Major Antagonize the effect of Betamethasone when combined with Mifepristone. Cushing syndrome [5A70] [25]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Betamethasone caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [26]
Ivacaftor DMZC1HS Moderate Decreased clearance of Betamethasone due to the transporter inhibition by Ivacaftor. Cystic fibrosis [CA25] [27]
MK-8228 DMOB58Q Moderate Decreased metabolism of Betamethasone caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [28]
Aprepitant DM053KT Moderate Decreased metabolism of Betamethasone caused by Aprepitant mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Betamethasone caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [19]
Primidone DM0WX6I Moderate Increased metabolism of Betamethasone caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [30]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Betamethasone caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Mephenytoin DM5UGDK Moderate Increased metabolism of Betamethasone caused by Mephenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Stiripentol DMMSDOY Moderate Decreased metabolism of Betamethasone caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Betamethasone caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Rufinamide DMWE60C Moderate Increased metabolism of Betamethasone caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [21]
Ethotoin DMXWOCP Moderate Increased metabolism of Betamethasone caused by Ethotoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Phenobarbital DMXZOCG Moderate Increased metabolism of Betamethasone caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [30]
Carbamazepine DMZOLBI Moderate Increased metabolism of Betamethasone caused by Carbamazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [34]
Mefenamic acid DMK7HFI Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Mefenamic acid. Female pelvic pain [GA34] [16]
Tazemetostat DMWP1BH Moderate Increased metabolism of Betamethasone caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [35]
Itraconazole DMCR1MV Moderate Decreased metabolism of Betamethasone caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [19]
Ketoconazole DMPZI3Q Moderate Decreased metabolism of Betamethasone caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [19]
Boceprevir DMBSHMF Moderate Decreased metabolism of Betamethasone caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [19]
Telaprevir DMMRV29 Moderate Decreased metabolism of Betamethasone caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Rifampin DMA8J1G Moderate Increased metabolism of Betamethasone caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [37]
Rifapentine DMCHV4I Moderate Increased metabolism of Betamethasone caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [38]
Delavirdine DM3NF5G Moderate Decreased metabolism of Betamethasone caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Betamethasone caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Betamethasone caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Efavirenz DMC0GSJ Moderate Increased metabolism of Betamethasone caused by Efavirenz mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [39]
Saquinavir DMG814N Moderate Decreased metabolism of Betamethasone caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Etravirine DMGV8QU Moderate Increased metabolism of Betamethasone caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [40]
Amprenavir DMLMXE0 Moderate Decreased metabolism of Betamethasone caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Darunavir DMN3GCH Moderate Decreased metabolism of Betamethasone caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Atazanavir DMSYRBX Moderate Decreased metabolism of Betamethasone caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Ritonavir DMU764S Moderate Decreased metabolism of Betamethasone caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Bempedoic acid DM1CI9R Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Bempedoic acid. Hyper-lipoproteinaemia [5C80] [41]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Betamethasone and Teriflunomide. Hyper-lipoproteinaemia [5C80] [42]
Conivaptan DM1V329 Moderate Decreased metabolism of Betamethasone caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [19]
Meclofenamic acid DM05FXR Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [43]
Amobarbital DM0GQ8N Moderate Increased metabolism of Betamethasone caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [30]
Methotrexate DM2TEOL Moderate Additive immunosuppressive effects by the combination of Betamethasone and Methotrexate. Leukaemia [2A60-2B33] [44]
Denosumab DMNI0KO Moderate Additive immunosuppressive effects by the combination of Betamethasone and Denosumab. Low bone mass disorder [FB83] [45]
Ceritinib DMB920Z Moderate Decreased metabolism of Betamethasone caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [19]
PF-06463922 DMKM7EW Moderate Increased metabolism of Betamethasone caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [46]
Selpercatinib DMZR15V Moderate Decreased metabolism of Betamethasone caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [21]
Idelalisib DM602WT Moderate Decreased metabolism of Betamethasone caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [19]
IPI-145 DMWA24P Moderate Decreased metabolism of Betamethasone caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [47]
Nivolumab DMAB9QE Moderate Additive immunosuppressive effects by the combination of Betamethasone and Nivolumab. Melanoma [2C30] [19]
Pembrolizumab DMFQEA6 Moderate Additive immunosuppressive effects by the combination of Betamethasone and Pembrolizumab. Melanoma [2C30] [19]
Ipilimumab DMJTIYK Moderate Additive immunosuppressive effects by the combination of Betamethasone and Ipilimumab. Melanoma [2C30] [19]
Cemiplimab DMKMJHE Moderate Additive immunosuppressive effects by the combination of Betamethasone and Cemiplimab. Melanoma [2C30] [19]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Betamethasone caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [21]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Betamethasone and Thalidomide. Multiple myeloma [2A83] [48]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Betamethasone and Tecfidera. Multiple sclerosis [8A40] [49]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Betamethasone and Siponimod. Multiple sclerosis [8A40] [20]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Betamethasone and Fingolimod. Multiple sclerosis [8A40] [50]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Betamethasone and Ocrelizumab. Multiple sclerosis [8A40] [51]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Betamethasone and Ozanimod. Multiple sclerosis [8A40] [21]
Rifabutin DM1YBHK Moderate Increased metabolism of Betamethasone caused by Rifabutin mediated induction of CYP450 enzyme. Mycobacterium infection [1B10-1B21] [52]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Betamethasone caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [19]
Nilotinib DM7HXWT Moderate Decreased metabolism of Betamethasone caused by Nilotinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [53]
Imatinib DM7RJXL Moderate Decreased metabolism of Betamethasone caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [54]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Betamethasone and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [55]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Betamethasone and Bupropion. Nicotine use disorder [6C4A] [56]
Atezolizumab DMMF8U0 Moderate Additive immunosuppressive effects by the combination of Betamethasone and Atezolizumab. Non-small cell lung cancer [2C25] [19]
Rofecoxib DM3P5DA Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Rofecoxib. Osteoarthritis [FA00-FA05] [16]
Valdecoxib DMAY7H4 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Valdecoxib. Osteoarthritis [FA00-FA05] [16]
Diclofenac DMPIHLS Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Diclofenac. Osteoarthritis [FA00-FA05] [16]
Naproxen DMZ5RGV Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Naproxen. Osteoarthritis [FA00-FA05] [16]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Betamethasone caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [57]
Aspirin DM672AH Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Aspirin. Pain [MG30-MG3Z] [58]
Diflunisal DM7EN8I Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Diflunisal. Pain [MG30-MG3Z] [16]
Ibuprofen DM8VCBE Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Ibuprofen. Pain [MG30-MG3Z] [16]
Nabumetone DMAT2XH Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Nabumetone. Pain [MG30-MG3Z] [16]
Piroxicam DMTK234 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Piroxicam. Pain [MG30-MG3Z] [16]
Abametapir DM2RX0I Moderate Decreased metabolism of Betamethasone caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [59]
Lefamulin DME6G97 Moderate Decreased metabolism of Betamethasone caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [60]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Betamethasone caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [19]
Ritodrine DM4V6RL Minor Increased risk of hypokalemia by the combination of Betamethasone and Ritodrine. Preterm labour/delivery [JB00] [19]
Bosentan DMIOGBU Moderate Increased metabolism of Betamethasone caused by Bosentan mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [61]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Betamethasone and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [62]
Gatifloxacin DMSL679 Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Gatifloxacin. Respiratory infection [CA07-CA4Z] [22]
Salsalate DM13P4C Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Salsalate. Rheumatoid arthritis [FA20] [15]
Meloxicam DM2AR7L Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Meloxicam. Rheumatoid arthritis [FA20] [16]
Sulindac DM2QHZU Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Sulindac. Rheumatoid arthritis [FA20] [16]
Celecoxib DM6LOQU Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Celecoxib. Rheumatoid arthritis [FA20] [16]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Betamethasone and Canakinumab. Rheumatoid arthritis [FA20] [63]
Oxaprozin DM9UB0P Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Oxaprozin. Rheumatoid arthritis [FA20] [16]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Betamethasone and Rilonacept. Rheumatoid arthritis [FA20] [63]
Flurbiprofen DMGN4BY Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Flurbiprofen. Rheumatoid arthritis [FA20] [16]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Betamethasone and Golimumab. Rheumatoid arthritis [FA20] [64]
Fenoprofen DML5VQ0 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Fenoprofen. Rheumatoid arthritis [FA20] [16]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Betamethasone and Leflunomide. Rheumatoid arthritis [FA20] [42]
Tolmetin DMWUIJE Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Tolmetin. Rheumatoid arthritis [FA20] [16]
Salicyclic acid DM2F8XZ Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Salicyclic acid. Seborrhoeic dermatitis [EA81] [58]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Betamethasone when combined with Anthrax vaccine. Sepsis [1G40-1G41] [65]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Betamethasone caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [19]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Betamethasone caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [21]
Larotrectinib DM26CQR Moderate Decreased metabolism of Betamethasone caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [20]
Armodafinil DMGB035 Minor Increased metabolism of Betamethasone caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [66]
LEE011 DMMX75K Moderate Decreased metabolism of Betamethasone caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [67]
Pitolisant DM8RFNJ Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Betamethasone and Pitolisant. Somnolence [MG42] [21]
Fostamatinib DM6AUHV Moderate Decreased clearance of Betamethasone due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [68]
Pipecuronium DM5F84A Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Pipecuronium. Tonus and reflex abnormality [MB47] [19]
Doxacurium DMKE7L9 Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Doxacurium. Tonus and reflex abnormality [MB47] [19]
Vecuronium DMP0UK2 Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Vecuronium. Tonus and reflex abnormality [MB47] [19]
Rocuronium DMY9BMK Moderate Additive neuromuscular blocking effects by the combination of Betamethasone and Rocuronium. Tonus and reflex abnormality [MB47] [19]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Betamethasone and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [62]
Durvalumab DM4PVDY Moderate Additive immunosuppressive effects by the combination of Betamethasone and Durvalumab. Ureteral cancer [2C92] [19]
Cinoxacin DM4EWNS Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Cinoxacin. Urinary tract infection [GC08] [22]
Nalidixic acid DMRM0JV Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Nalidixic acid. Urinary tract infection [GC08] [22]
Enoxacin DMYTE6L Major Increased risk of tendinitis/tendon rupture by the combination of Betamethasone and Enoxacin. Urinary tract infection [GC08] [22]
⏷ Show the Full List of 143 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Cetyl alcohol E00061 2682 Coating agent; Emollient; Emulsifying agent; Stiffening agent
Kyselina citronova E00014 311 Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Phosphoric acid E00039 1004 Acidulant; Buffering agent
Chlorocresol E00051 1732 Antimicrobial preservative
Ethanol E00023 702 Antimicrobial preservative; Penetration agent; Solvent
Polyethylene glycol 1000 E00647 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Potassium citrate E00225 13344 Alkalizing agent; Buffering agent; Complexing agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Propylene glycol monostearate E00239 14878 Emollient; Emulsifying agent; Surfactant
Sodium dihydrogenorthophosphate E00559 23672064 Buffering agent; Complexing agent
Sodium hydroxide E00234 14798 Alkalizing agent
Sodium phosphate monobasic monohydrate E00428 516949 Buffering agent; Complexing agent
Stearyl alcohol E00172 8221 Emollient; Emulsifying agent; Stiffening agent; Viscosity-controlling agent
Water E00035 962 Solvent
Butane E00155 7843 Aerosol propellant
Cyclomethicone E00203 10913 Emollient; Humectant; Viscosity-controlling agent
Polyoxyl 20 cetyl ether E00452 2724259 Emulsifying agent; Ointment base; Solubilizing agent; Surfactant
Propane E00115 6334 Aerosol propellant
Sorbitan tristearate E00516 17800859 Dispersing agent; Emulsifying agent; Solubilizing agent; Surfactant; Suspending agent; Vaccine adjuvant
Polysorbate 60 E00715 Not Available Dispersing agent; Emollient; Emulsifying agent; Surfactant; Plasticizing agent; Solubilizing agent; Suspending agent
⏷ Show the Full List of 20 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Betamethasone Valerate 0.1% cream 0.10% Cream Topical
Betamethasone 0.05% cream 0.05% Cream Topical
Betamethasone Valerate 0.12% aerosol 0.12% Aerosol Topical
Betamethasone 0.05% ointment 0.05% Ointment Topical
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Betamethasone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7061).
3 BDDCS applied to over 900 drugs
4 Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India. Clin Transl Sci. 2020 Mar;13(2):391-399. doi: 10.1111/cts.12724. Epub 2019 Dec 13.
5 Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.
6 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
7 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
8 The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83.
9 Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803.
10 Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.
11 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
12 [Steroid drugs and GM-CSF modulates activity of Egr-1 in glioma cells]. Cir Cir. 2013 Jan-Feb;81(1):3-13.
13 Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia. PLoS One. 2013;8(2):e55940.
14 Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties. Eur J Endocrinol. 2004 Sep;151(3):397-406. doi: 10.1530/eje.0.1510397.
15 Baer PA, Shore A, Ikeman RL "Transient fall in serum salicylate levels following intraarticular injection of steroid in patients with rheumatoid arthritis." Arthritis Rheum 30 (1987): 345-7. [PMID: 3566826]
16 Buchman AL, Schwartz MR "Colonic ulceration associated with the systemic use of nonsteroidal antiinflammatory medication." J Clin Gastroenterol 22 (1996): 224-6. [PMID: 8724264]
17 Albin H, Vincon G, Demotes-Mainard F, et al "Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone." Eur J Clin Pharmacol 26 (1984): 271-3. [PMID: 6723769]
18 Brooks SM, Werk EE, Ackerman SJ, Sullivan I, Thrasher K "Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma." N Engl J Med 286 (1972): 1125-8. [PMID: 4553339]
19 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
20 Cerner Multum, Inc. "Australian Product Information.".
21 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
22 FDA. U.S. Food and Drug Administration "Information for Healthcare Professionals. Fluoroquinolone Antimicrobial Drugs. FDA Alert [7/8/2008].".
23 Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
24 Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
25 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
26 Cerner Multum, Inc. "Canadian Product Information.".
27 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
28 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
29 Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
30 Bartoszek M, Brenner AM, Szefler SJ "Prednisolone and methylprednisolone kinetics in children receiving anticonvulsant therapy." Clin Pharmacol Ther 42 (1987): 424-32. [PMID: 3665340]
31 Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
32 Frey BM, Frey FJ "Phenytoin modulates the pharmacokinetics of prednisolone and the pharmacodynamics of prednisolone as assessed by the inhibition of the mixed lymphocyte reaction in humans." Eur J Clin Invest 14 (1984): 1-6. [PMID: 6230241]
33 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
34 Keitner GI, Fruzzetti AE, Miller IW, Norman WH, Brown WA "The effect of anticonvulsants on the dexamethasone suppression test." Can J Psychiatry 34 (1989): 441-3. [PMID: 2766197]
35 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
36 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
37 Kyriazopoulou V, Parparousi O, Vagenakis AG "Rifampicin-induced adrenal crisis in Addisonian patients receiving corticosteroid replacement therapy." J Clin Endocrinol Metab 59 (1984): 1204-6. [PMID: 6490796]
38 Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
39 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
40 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
41 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
42 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
43 Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4. [PMID: 6343871]
44 Lafforgue P, Monjanel-Mouterde S, Durand A, Catalin J, Acquaviva PC "Is there an interaction between low doses of corticosteroids and methotrexate in patients with rheumatoid arthritis? A pharmacokinetic study in 33 patients." J Rheumatol 20 (1993): 263-7. [PMID: 8474062]
45 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
46 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
47 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
48 Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
49 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
50 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
51 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
52 Bergrem H, Refvem OK "Altered prednisolone pharmacokinetics in patients treated with rifampicin." Acta Med Scand 213 (1983): 339-43. [PMID: 6880856]
53 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
54 Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
55 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
56 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
57 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
58 Hansen RA, Tu W, Wang J, Ambuehl R, McDonald CJ, Murray MD "Risk of adverse gastrointestinal events from inhaled corticosteroids." Pharmacotherapy 28 (2008): 1325-34. [PMID: 18956992]
59 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
60 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
61 Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
62 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
63 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
64 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
65 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
66 Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
67 DSouza DL, Levasseur LM, Nezamis J, Robbins DK, Simms L, Koch KM "Effect of alosetron on the pharmacokinetics of alprazolam." J Clin Pharmacol 41 (2001): 452-4. [PMID: 11304902]
68 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.