Details of Disease

General Information of Disease (ID: DISWBRRN)

• Disease Name: Filarial disease
• Synonyms: disease due to superfamily Filarioidea
• Disease Class: 1F66: Filariasis
• Definition: A parasitic disease caused by tissue-invasive, vector-borne nematodes which can be found anywhere in the human body and that are transmitted to humans through the bite of an infected mosquito or fly or by consumption of unsafe drinking water and which, depending on the subtype can manifest with lymphedema, dermatitis, subcutaneous edema and eye involvement. The disorder is a major public health problem in many tropical and subtropical countries. Six subtypes have been described in the literature: lymphatic filariasis, onchocerciasis, loiasis, mansonelliasis, dirofilariasis and dracunculiasis caused by Wuchereria bancrofti and filarioidea of the genus Brugia; Onchocerca volvulus; Loa loa; Mansonella; Dirofilaria; and Dracunculus medinensis, respectively. Tropical eosinophilia is considered a frequent manifestation.
• Disease Hierarchy:
  DIS7CGKY: Helminth infection
  DISWBRRN: Filarial disease
• ICD Code:
  ICD-11: ICD-11: 1F66
  Expand ICD-11: '1F66
  Expand ICD-10: 'B74; 'B74.8; 'B74.9
• Disease Identifiers:
  MONDO ID: MONDO_0016075
  MESH ID: D005368
  UMLS CUI: C0016085
  MedGen ID: 4706
  Orphanet ID: 2034
  SNOMED CT ID: 105706003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ABBV-4083	DMMUD4G	Phase 1	Small molecular drug	[1]
Emodepside	DMQS9NW	Phase 1	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
F13A1	TTXI2RA	moderate	Biomarker	[3]
F13B	TTAXGIP	moderate	Biomarker	[3]
LGALS2	TTRHK90	moderate	Biomarker	[4]
TGM1	TT7A949	moderate	Biomarker	[3]
TNFRSF18	TTG6LA7	moderate	Biomarker	[5]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
DTYMK	DEOTVYU	moderate	Biomarker	[6]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALKBH1	OTADGU5D	moderate	Biomarker	[7]
CALU	OTSYQN71	moderate	Biomarker	[8]
GPT2	OTS5VF7N	moderate	Biomarker	[9]

References

• [1] Clinical pipeline report, company report or official report of AbbVie.
• [2] ClinicalTrials.gov (NCT03383614) Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside. U.S. National Institutes of Health.
• [3] Molecular characterization of a Brugia malayi transglutaminase.Parasitol Res. 2004 Jun;93(2):145-50. doi: 10.1007/s00436-004-1121-9. Epub 2004 May 1.
• [4] Brugia malayi galectin 2 is a tandem-repeat type galectin capable of binding mammalian polysaccharides.Mol Biochem Parasitol. 2020 Jan;235:111233. doi: 10.1016/j.molbiopara.2019.111233. Epub 2019 Nov 15.
• [5] Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.J Immunol. 2011 Aug 1;187(3):1411-20. doi: 10.4049/jimmunol.1100834. Epub 2011 Jun 24.
• [6] Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK).Int J Biol Macromol. 2016 Jul;88:565-71. doi: 10.1016/j.ijbiomac.2016.04.004. Epub 2016 Apr 1.
• [7] The association of blood groups, ABH secretion, haptoglobins and hemoglobins with filariasis.Hum Hered. 1976;26(2):105-9. doi: 10.1159/000152789.
• [8] Novel Findings of Anti-Filarial Drug Target and Structure-Based Virtual Screening for Drug Discovery.Int J Mol Sci. 2018 Nov 13;19(11):3579. doi: 10.3390/ijms19113579.
• [9] Bacterial lipid modification enhances immunoprophylaxis of filarial abundant larval transcript-2 protein in Mastomys model.Parasite Immunol. 2013 Jul;35(7-8):201-13. doi: 10.1111/pim.12034.