Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWPAJD)

• DME Name: Aminoglycoside O-phosphotransferase (aphA6)
• Synonyms: Aminoglycoside 3'-phosphotransferase; Kanamycin kinase, type VI; Neomycin-kanamycin phosphotransferase type VI; APH(3')VI; aphA-6
• Gene Name: aphA-6
• UniProt ID: KKA6_ACIBA
• INTEDE ID: DME1068
• Gene ID: 20472049
• EC Number:
  EC: 2.7.1.95
  Transferase
  Kinase
  Phosphotransferase
  EC: 2.7.1.95
• Lineage:
  Species: Acinetobacter baumannii
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Pseudomonadales
  Family: Moraxellaceae
  Genus: Acinetobacter
  Species: Acinetobacter baumannii
• Tissue Distribution: Primarily distributed in human lung.
• Sequence:
  MELPNIIQQFIGNSVLEPNKIGQSPSDVYSFNRNNETFFLKRSSTLYTETTYSVSREAKM
  LSWLSEKLKVPELIMTFQDEQFEFMITKAINAKPISALFLTDQELLAIYKEALNLLNSIA
  IIDCPFISNIDHRLKESKFFIDNQLLDDIDQDDFDTELWGDHKTYLSLWNELTETRVEER
  LVFSHGDITDSNIFIDKFNEIYFLDLGRAGLADEFVDISFVERCLREDASEETAKIFLKH
  LKNDRPDKRNYFLKLDELN
• Function: This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A.

Molecular Interaction Atlas (MIA) of This DME

7 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacterial infection	1A00-1C4Z	Approved	[1]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[1]
Gentamicin	DMKINJO	Bacterial infection	1A00-1C4Z	Approved	[1]
Kanamycin	DMITFB8	Pulmonary tuberculosis	1B10.Z	Approved	[1]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[1]
Streptomycin	DMSRXVM	Endocarditis	BB40-BA42	Approved	[1]
Tobramycin	DMUI0CH	Bacterial infection	1A00-1C4Z	Approved	[1]

References

• [1] Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.