General Information of Drug Off-Target (DOT) (ID: OT20GHN3)

DOT Name MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)
Synonyms Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI-67; hNIFK
Gene Name NIFK
UniProt ID
MK67I_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2AFF; 8FKP; 8FKQ; 8FKR; 8FKS; 8FKT; 8FKU; 8FKV; 8FKW; 8FKX; 8FKY; 8FKZ; 8FL2; 8FL3; 8FL6; 8FL7; 8FLA; 8FLB; 8FLD; 8FLE; 8INE; 8INF; 8IPX; 8IPY; 8IR3
Pfam ID
PF12196 ; PF00076
Sequence
MATFSGPAGPILSLNPQEDVEFQKEVAQVRKRITQRKKQEQLTPGVVYVRHLPNLLDETQ
IFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMNNYLFGERLLECHF
MPPEKVHKELFKDWNIPFKQPSYPSVKRYNRNRTLTQKLRMEERFKKKERLLRKKLAKKG
IDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVSGTLDTPEKTVDSQGPTPVCTPT
FLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQETQTPTHSRKKRRRSSNQ

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
5 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [1]
Quercetin DM3NC4M Approved Quercetin increases the phosphorylation of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [8]
TAK-243 DM4GKV2 Phase 1 TAK-243 decreases the sumoylation of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [15]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 affects the phosphorylation of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [8]
Coumarin DM0N8ZM Investigative Coumarin decreases the phosphorylation of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [8]
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16 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [2]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [3]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [4]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [5]
Estradiol DMUNTE3 Approved Estradiol increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [6]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [7]
Temozolomide DMKECZD Approved Temozolomide increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [9]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [10]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [11]
Clozapine DMFC71L Approved Clozapine decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [12]
Haloperidol DM96SE0 Approved Haloperidol decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [12]
Sodium phenylbutyrate DMXLBCQ Approved Sodium phenylbutyrate decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [13]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [14]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [16]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [17]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK). [18]
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⏷ Show the Full List of 16 Drug(s)

References

1 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
3 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
4 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
5 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
6 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
7 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
8 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
9 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
10 [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
11 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
12 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
13 Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics. 2004 Jan 15;16(2):204-11.
14 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
15 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
16 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
17 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
18 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.