Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT47CHQR)

• DOT Name: Spermatogenesis-associated protein 19, mitochondrial (SPATA19)
• Synonyms: Spermatogenic cell-specific gene 1 protein; Spergen-1
• Gene Name: SPATA19
• Related Disease:
  Advanced cancer
  Benign prostatic hyperplasia
  Metastatic malignant neoplasm
  Neoplasm
  Prostate adenocarcinoma
  Prostate neoplasm
  Prostate cancer
  Prostate carcinoma
• UniProt ID: SPT19_HUMAN
• Pfam ID: PF15212
• Sequence:
  MIITTWIVYILARKGVGLPFLPITSSDIDVVESEAVSVLHHWLKKTEEEASRGIKEKLSI
  NHPSQGVREKMSTDSPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWS
  HTRIFQVPSEMTEDIMRDRIEQVRRSISRLTDVSAQDFSMRPSSSDC
• Function: Essential for sperm motility and male fertility. Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly.
• Tissue Specificity: Expressed specifically in testis.

Molecular Interaction Atlas (MIA) of This DOT

8 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Altered Expression	[1]
Benign prostatic hyperplasia	DISI3CW2	Strong	Altered Expression	[2]
Metastatic malignant neoplasm	DIS86UK6	Strong	Altered Expression	[3]
Neoplasm	DISZKGEW	Strong	Altered Expression	[3]
Prostate adenocarcinoma	DISBZYU8	Strong	Biomarker	[3]
Prostate neoplasm	DISHDKGQ	Strong	Biomarker	[3]
Prostate cancer	DISF190Y	moderate	Altered Expression	[2]
Prostate carcinoma	DISMJPLE	moderate	Altered Expression	[2]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the expression of Spermatogenesis-associated protein 19, mitochondrial (SPATA19).	[4]

References

• [1] Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.Br J Dermatol. 2010 Apr;162(4):772-9. doi: 10.1111/j.1365-2133.2009.09568.x. Epub 2009 Nov 3.
• [2] Cancer/testis antigen SPATA19 is frequently expressed in benign prostatic hyperplasia and prostate cancer.APMIS. 2017 Dec;125(12):1092-1101. doi: 10.1111/apm.12775. Epub 2017 Oct 3.
• [3] SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3509-14. doi: 10.1073/pnas.0712269105. Epub 2008 Feb 26.
• [4] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.