General Information of Drug Off-Target (DOT) (ID: OTEUG8RL)

DOT Name Paraneoplastic antigen Ma1 (PNMA1)
Synonyms 37 kDa neuronal protein; Neuron- and testis-specific protein 1
Gene Name PNMA1
Related Disease
Hepatocellular carcinoma ( )
Nervous system inflammation ( )
UniProt ID
PNMA1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF14893 ; PF20846
Sequence
MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREEN
AKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVA
RVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPW
LEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSV
ESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANH
SGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF
Tissue Specificity Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hepatocellular carcinoma DIS0J828 Limited Altered Expression [1]
Nervous system inflammation DISB3X5A Limited Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
17 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of Paraneoplastic antigen Ma1 (PNMA1). [3]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [4]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Paraneoplastic antigen Ma1 (PNMA1). [5]
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [6]
Doxorubicin DMVP5YE Approved Doxorubicin increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [7]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [8]
Quercetin DM3NC4M Approved Quercetin increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [10]
Temozolomide DMKECZD Approved Temozolomide decreases the expression of Paraneoplastic antigen Ma1 (PNMA1). [11]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [12]
Clozapine DMFC71L Approved Clozapine increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [13]
Benzatropine DMF7EXL Approved Benzatropine increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [13]
Urethane DM7NSI0 Phase 4 Urethane affects the expression of Paraneoplastic antigen Ma1 (PNMA1). [14]
Phenol DM1QSM3 Phase 2/3 Phenol decreases the expression of Paraneoplastic antigen Ma1 (PNMA1). [15]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [16]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [17]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [18]
Resorcinol DMM37C0 Investigative Resorcinol increases the expression of Paraneoplastic antigen Ma1 (PNMA1). [19]
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⏷ Show the Full List of 17 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Arsenic DMTL2Y1 Approved Arsenic affects the methylation of Paraneoplastic antigen Ma1 (PNMA1). [9]
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References

1 PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/-catenin pathway.Biomed Pharmacother. 2018 Dec;108:492-499. doi: 10.1016/j.biopha.2018.09.059. Epub 2018 Sep 19.
2 Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat.Brain. 2004 Aug;127(Pt 8):1822-30. doi: 10.1093/brain/awh205. Epub 2004 Jun 16.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
5 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
6 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
7 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
8 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
9 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
10 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
11 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
12 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
13 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
14 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
15 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
16 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
17 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
18 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
19 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.