Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTFQ1VGM)

• DOT Name: Patched domain-containing protein 3 (PTCHD3)
• Synonyms: Patched-related protein
• Gene Name: PTCHD3
• Related Disease:
  Advanced cancer
  Neoplasm
  Asthma
  Autism spectrum disorder
  Glaucoma/ocular hypertension
  Hereditary hemochromatosis
  Metastatic malignant neoplasm
• UniProt ID: PTHD3_HUMAN
• Pfam ID: PF02460
• Sequence:
  MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL
  ASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLE
  GLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKA
  ERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLR
  VAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF
  FGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALK
  KIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVI
  SAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMS
  NVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL
  DGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSE
  SKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVI
  VTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMN
  NIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPL
  MVYNQAFIYFDQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVT
  GFMAFWKVNLDSISMINLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVL
  QSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMIFGAAHGLIFIPVFLTFFGRFI
• Function: May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
• Tissue Specificity: Expressed in germ cells of the testis (at protein level) . Detected in blood lymph, colon, small intestine, ovary, testis, prostate, thymus and spleen with highest levels in testis .

Molecular Interaction Atlas (MIA) of This DOT

7 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Biomarker	[1]
Neoplasm	DISZKGEW	Strong	Biomarker	[2]
Asthma	DISW9QNS	Limited	Genetic Variation	[3]
Autism spectrum disorder	DISXK8NV	Limited	Genetic Variation	[4]
Glaucoma/ocular hypertension	DISLBXBY	Limited	Biomarker	[5]
Hereditary hemochromatosis	DISVG5MT	Limited	Biomarker	[4]
Metastatic malignant neoplasm	DIS86UK6	Limited	Biomarker	[6]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Patched domain-containing protein 3 (PTCHD3).	[7]

References

• [1] Systematic acute and subchronic toxicity evaluation of polysaccharide-protein complex-functionalized selenium nanoparticles with anticancer potency.Biomater Sci. 2019 Nov 19;7(12):5112-5123. doi: 10.1039/c9bm01104h.
• [2] Left-sided primary tumor is a favorable prognostic factor for metastatic colorectal cancer patients receiving surgery.Oncotarget. 2017 Jun 30;8(45):79618-79628. doi: 10.18632/oncotarget.18896. eCollection 2017 Oct 3.
• [3] Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study.Immunogenetics. 2016 Jul;68(6-7):391-400. doi: 10.1007/s00251-016-0914-1. Epub 2016 May 3.
• [4] Human PTCHD3 nulls: rare copy number and sequence variants suggest a non-essential gene.BMC Med Genet. 2011 Mar 26;12:45. doi: 10.1186/1471-2350-12-45.
• [5] Asymmetry of Peak Thicknesses between the Superior and Inferior Retinal Nerve Fiber Layers for Early Glaucoma Detection: A Simple Screening Method.Yonsei Med J. 2018 Jan;59(1):135-140. doi: 10.3349/ymj.2018.59.1.135.
• [6] Outcomes of surgery for gastric cancer with distant metastases: a retrospective study from the SEER database.Oncotarget. 2017 Jan 17;8(3):4342-4351. doi: 10.18632/oncotarget.14027.
• [7] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.