Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTG2O6S4)

• DOT Name: Heat shock transcription factor, Y-linked (HSFY2)
• Synonyms: Heat shock transcription factor 2-like protein; HSF2-like
• Gene Name: HSFY2
• Related Disease:
  Azoospermia
  Colon cancer
  Colon carcinoma
  Male infertility
  Oligospermia
• UniProt ID: HSFY1_HUMAN
• Pfam ID: PF00447
• Sequence:
  MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIEEHAFQVLSQGSLLESP
  SYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEELFKKEILETK
  APYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSKLKFYYNPNF
  KRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAAEASEESLFS
  ASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHAILNQLTTIH
  MHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPLVSVNEAPYR
  NMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
• Tissue Specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Azoospermia	DIS94181	Strong	Genetic Variation	[1]
Colon cancer	DISVC52G	Strong	Biomarker	[2]
Colon carcinoma	DISJYKUO	Strong	Biomarker	[2]
Male infertility	DISY3YZZ	Strong	Genetic Variation	[3]
Oligospermia	DIS6YJF3	Strong	Biomarker	[1]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen increases the expression of Heat shock transcription factor, Y-linked (HSFY2).	[4]

References

• [1] Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility.Biol Reprod. 2004 Jul;71(1):297-306. doi: 10.1095/biolreprod.103.023580. Epub 2004 Mar 24.
• [2] The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906.Evid Based Complement Alternat Med. 2017;2017:8753815. doi: 10.1155/2017/8753815. Epub 2017 May 15.
• [3] Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis.Mol Hum Reprod. 2004 Apr;10(4):253-8. doi: 10.1093/molehr/gah036. Epub 2004 Feb 16.
• [4] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.