Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTLBWKZA)

DOT Name Homeobox protein TGIF2LX (TGIF2LX)
Synonyms TGF-beta-induced transcription factor 2-like protein; TGFB-induced factor 2-like protein, X-linked; TGIF-like on the X
Gene Name TGIF2LX
Related Disease
Prostate cancer ( )
Prostate carcinoma ( )
Prostate neoplasm ( )
Female hypogonadism ( )
Colon adenocarcinoma ( )
Neoplasm ( )
UniProt ID
TF2LX_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2DMN
Pfam ID
PF05920
Sequence
MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAE
SVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLQISNWFINARRRILPDMLQQRRNDP
IIGHKTGKDAHATHLQSTEASVPAKSGPSGPDNVQSLPLWPLPKGQMSREKQPDPESAPS
QKLTGIAQPKKKVKVSVTSPSSPELVSPEEHADFSSFLLLVDAAVQRAAELELEKKQEPN
P
Function May have a transcription role in testis.
Tissue Specificity Specifically expressed in adult testis.

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Prostate cancer DISF190Y Strong Altered Expression [1]
Prostate carcinoma DISMJPLE Strong Altered Expression [1]
Prostate neoplasm DISHDKGQ Strong Genetic Variation [1]
Female hypogonadism DISWASB4 moderate Biomarker [2]
Colon adenocarcinoma DISDRE0J Limited Biomarker [3]
Neoplasm DISZKGEW Limited Biomarker [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Homeobox protein TGIF2LX (TGIF2LX). [4]
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References

1 Association of TGIFLX/Y mRNA expression with prostate cancer.Med Oncol. 2009;26(1):73-7. doi: 10.1007/s12032-008-9086-7. Epub 2008 Jul 29.
2 Copy number variants on the X chromosome in women with primary ovarian insufficiency.Fertil Steril. 2011 Apr;95(5):1584-8.e1. doi: 10.1016/j.fertnstert.2011.01.018. Epub 2011 Feb 12.
3 Homeodomain Protein Transforming Growth Factor Beta-Induced Factor 2 Like, X-Linked Function in Colon Adenocarcinoma Cells.Asian Pac J Cancer Prev. 2017 Aug 27;18(18):2101-2108. doi: 10.22034/APJCP.2017.18.8.2101.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.