Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTNX5LPF)

DOT Name Choline/ethanolamine kinase (CHKB)
Synonyms Choline kinase beta; CK; CKB; EC 2.7.1.32; Choline kinase-like protein; Ethanolamine kinase; EK; EC 2.7.1.82; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB
Gene Name CHKB
Related Disease
Megaconial type congenital muscular dystrophy ( )
UniProt ID
CHKB_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2IG7; 3FEG; 3LQ3
EC Number
2.7.1.32; 2.7.1.82
Pfam ID
PF01633
Sequence
MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
Function Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
KEGG Pathway
Glycerophospholipid metabolism (hsa00564 )
Metabolic pathways (hsa01100 )
Choline metabolism in cancer (hsa05231 )
Reactome Pathway
Synthesis of PE (R-HSA-1483213 )
Synthesis of PC (R-HSA-1483191 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Megaconial type congenital muscular dystrophy DIS8MWRB Strong Autosomal recessive [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Choline/ethanolamine kinase (CHKB). [2]
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3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin increases the expression of Choline/ethanolamine kinase (CHKB). [3]
Carbamazepine DMZOLBI Approved Carbamazepine affects the expression of Choline/ethanolamine kinase (CHKB). [4]
Diclofenac DMPIHLS Approved Diclofenac affects the expression of Choline/ethanolamine kinase (CHKB). [4]
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References

1 A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Am J Hum Genet. 2011 Jun 10;88(6):845-851. doi: 10.1016/j.ajhg.2011.05.010.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
4 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.