Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQVDS8D)

DOT Name Testis-specific chromodomain protein Y 1 (CDY1)
Synonyms EC 2.3.1.48
Gene Name CDY1
Related Disease
Azoospermia ( )
Plasma cell myeloma ( )
Prostate cancer ( )
Prostate carcinoma ( )
Oligospermia ( )
UniProt ID
CDY1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2FBM; 6V41
EC Number
2.3.1.48
Pfam ID
PF00385 ; PF00378
Sequence
MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHLMNCEKCVHDFNRRQTE
KQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNRKLFAASKNVRR
KAASILSDTKNMEIINSTIETLAPDSPFDHKTVSGFQKLEKLDPIAADQQDTVVFKVTEG
KLLRDPLSRPGAEQTGIQNKTQIHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGT
TDMHTSVPRVKGGQRNITDDSRDQPFIKKMHFTIRLTESASTYRDIVVKKEDGFTQIVLS
TRSTEKNALNTEVIKEIVNALNSAAADDSKLVLFSAAGSVFCCGLDFGYFVKHLRNNRNT
ASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTF
GQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIK
ELASYNPIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENKIDEF
Function Has histone acetyltransferase activity, with a preference for histone H4.
Tissue Specificity Testis-specific. Detected in spermatids (at protein level).

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Azoospermia DIS94181 Strong Genetic Variation [1]
Plasma cell myeloma DIS0DFZ0 Strong Altered Expression [2]
Prostate cancer DISF190Y Strong Altered Expression [3]
Prostate carcinoma DISMJPLE Strong Altered Expression [3]
Oligospermia DIS6YJF3 moderate Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Doxorubicin DMVP5YE Approved Testis-specific chromodomain protein Y 1 (CDY1) decreases the response to substance of Doxorubicin. [4]
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References

1 Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.J Assist Reprod Genet. 2015 Sep;32(9):1333-41. doi: 10.1007/s10815-015-0520-4. Epub 2015 Jul 7.
2 Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol. 2013 Apr;88(4):265-72.
3 DNA methylation regulates the expression of Y chromosome specific genes in prostate cancer.J Urol. 2002 Jan;167(1):335-8.
4 Nuclear proteomics with XRCC3 knockdown to reveal the development of doxorubicin-resistant uterine cancer. Toxicol Sci. 2014 Jun;139(2):396-406. doi: 10.1093/toxsci/kfu051. Epub 2014 Mar 27.