Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTRJF3OY)

• DOT Name: Keratinocyte proline-rich protein (KPRP)
• Synonyms: hKPRP
• Gene Name: KPRP
• Related Disease:
  Alzheimer disease
  Alzheimer disease 3
  Atopic dermatitis
  Psoriasis
• UniProt ID: KPRP_HUMAN
• Sequence:
  MCDQQQIQCRLPLQQCCVKGPSFCSSQSPFAQSQVVVQAPCEMQIVDCPASCPVQVCQVS
  DQAPCQSQTTQVKCQSKTKQVKGQAQCQSKTTQVKGQAASQSQTSSVQSQAPCQSEVSYV
  QCEASQPVQTCFVECAPVCYTETCYVECPVQNYVPCPAPQPVQMYRGRPAVCQPQGRFST
  QCQYQGSYSSCGPQFQSRATCNNYTPQFQLRPSYSSCFPQYRSRTSFSPCVPQCQTQGSY
  GSFTEQHRSRSTSRCLPPPRRLQLFPRSCSPPRRFEPCSSSYLPLRPSEGFPNYCTPPRR
  SEPIYNSRCPRRPISSCSQRRGPKCRIEISSPCCPRQVPPQRCPVEIPPIRRRSQSCGPQ
  PSWGASCPELRPHVEPRPLPSFCPPRRLDQCPESPLQRCPPPAPRPRLRPEPCISLEPRP
  RPLPRQLSEPCLYPEPLPALRPTPRPVPLPRPGQCEIPEPRPCLQPCEHPEPCPRPEPIP
  LPAPCPSPEPCRETWRSPSPCWGPNPVPYPGDLGCHESSPHRLDTEAPYCGPSSYNQGQE
  SGAGCGPGDVFPERRGQDGHGDQGNAFAGVKGEAKSAYF
• Tissue Specificity: Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.

Molecular Interaction Atlas (MIA) of This DOT

4 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Alzheimer disease	DISF8S70	Strong	Altered Expression	[1]
Alzheimer disease 3	DISVT69G	Strong	Altered Expression	[1]
Atopic dermatitis	DISTCP41	Strong	Biomarker	[1]
Psoriasis	DIS59VMN	Limited	Genetic Variation	[2]

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Genistein	DM0JETC	Phase 2/3	Genistein decreases the expression of Keratinocyte proline-rich protein (KPRP).	[3]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Keratinocyte proline-rich protein (KPRP).	[5]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Keratinocyte proline-rich protein (KPRP).	[4]

References

• [1] Keratinocyte Proline-Rich Protein DeficiencyinAtopic Dermatitis Leads to Barrier Disruption.J Invest Dermatol. 2019 Sep;139(9):1867-1875.e7. doi: 10.1016/j.jid.2019.02.030. Epub 2019 Mar 21.
• [2] Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.Nat Commun. 2015 Apr 9;6:6793. doi: 10.1038/ncomms7793.
• [3] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [4] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [5] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.