Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTRPANSO)

DOT Name	Long-chain-fatty-acid--CoA ligase ACSBG2 (ACSBG2)
Synonyms	EC 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2; EC 6.2.1.15; Bubblegum-related protein; PRTD-NY3
Gene Name	ACSBG2
Related Disease	Male infertility ( ) Adrenoleukodystrophy ( ) Tuberculosis ( )
UniProt ID	ACBG2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	6.2.1.15; 6.2.1.3
Pfam ID	PF00501
Sequence	MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ IDHMYH
Function	Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Tissue Specificity	Testis-specific.
KEGG Pathway	Fatty acid biosynthesis (hsa00061 ) Fatty acid degradation (hsa00071 ) Metabolic pathways (hsa01100 ) Fatty acid metabolism (hsa01212 ) PPAR sig.ling pathway (hsa03320 ) Adipocytokine sig.ling pathway (hsa04920 )
Reactome Pathway	Synthesis of very long-chain fatty acyl-CoAs (R-HSA-75876 )
BioCyc Pathway	MetaCyc:HS05377-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance
Male infertility	DISY3YZZ	Strong	Biomarker	[1]
Adrenoleukodystrophy	DISTUD1F	moderate	Altered Expression	[2]
Tuberculosis	DIS2YIMD	Limited	Biomarker	[3]
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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Long-chain-fatty-acid--CoA ligase ACSBG2 (ACSBG2).	[4]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Long-chain-fatty-acid--CoA ligase ACSBG2 (ACSBG2).	[5]
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References

1	Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis.Asian J Androl. 2005 Mar;7(1):21-32. doi: 10.1111/j.1745-7262.2005.00014.x.
2	The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.J Biol Chem. 2006 Mar 10;281(10):6632-41. doi: 10.1074/jbc.M511558200. Epub 2005 Dec 21.
3	Bulgarian specificity and controversial phylogeography of Mycobacterium tuberculosis spoligotype ST 125__BGR.FEMS Immunol Med Microbiol. 2010 Jun 1;59(1):90-9. doi: 10.1111/j.1574-695X.2010.00667.x. Epub 2010 Mar 4.
4	Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
5	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.