General Information of Drug Off-Target (DOT) (ID: OTVGZOB5)

DOT Name Small ribosomal subunit protein uS9 (RPS16)
Synonyms 40S ribosomal protein S16
Gene Name RPS16
Related Disease
Breast cancer ( )
Breast carcinoma ( )
Pancreatic tumour ( )
UniProt ID
RS16_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4UG0 ; 4V6X ; 5A2Q ; 5AJ0 ; 5FLX ; 5LKS ; 5OA3 ; 5T2C ; 5VYC ; 6FEC ; 6G18 ; 6G4S ; 6G4W ; 6G51 ; 6G53 ; 6G5H ; 6G5I ; 6IP5 ; 6IP6 ; 6IP8 ; 6OLE ; 6OLF ; 6OLG ; 6OLI ; 6OLZ ; 6OM0 ; 6OM7 ; 6QZP ; 6XA1 ; 6Y0G ; 6Y2L ; 6Y57 ; 6YBS ; 6Z6L ; 6Z6M ; 6Z6N ; 6ZLW ; 6ZM7 ; 6ZME ; 6ZMI ; 6ZMO ; 6ZMT ; 6ZMW ; 6ZN5 ; 6ZOJ ; 6ZOL ; 6ZON ; 6ZP4 ; 6ZUO ; 6ZV6 ; 6ZVH ; 6ZVJ ; 6ZXD ; 6ZXE ; 6ZXF ; 6ZXG ; 6ZXH ; 7A09 ; 7K5I ; 7MQ8 ; 7MQ9 ; 7MQA ; 7QP6 ; 7QP7 ; 7R4X ; 7TQL ; 7WTT ; 7WTU ; 7WTV ; 7WTW ; 7WTX ; 7WTZ ; 7WU0 ; 7XNX ; 7XNY ; 8G5Y ; 8G60 ; 8G61 ; 8G6J ; 8GLP ; 8JDJ ; 8JDK ; 8JDL ; 8JDM ; 8PPK ; 8PPL ; 8T4S
Pfam ID
PF00380
Sequence
MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGK
ERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLL
VADPRRCESKKFGGPGARARYQKSYR
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
KEGG Pathway
Ribosome (hsa03010 )
Coro.virus disease - COVID-19 (hsa05171 )
Reactome Pathway
Peptide chain elongation (R-HSA-156902 )
SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 )
Viral mRNA Translation (R-HSA-192823 )
Selenocysteine synthesis (R-HSA-2408557 )
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )
Translation initiation complex formation (R-HSA-72649 )
Formation of a pool of free 40S subunits (R-HSA-72689 )
Formation of the ternary complex, and subsequently, the 43S complex (R-HSA-72695 )
Ribosomal scanning and start codon recognition (R-HSA-72702 )
GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
Eukaryotic Translation Termination (R-HSA-72764 )
Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )
Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 )
SARS-CoV-1 modulates host translation machinery (R-HSA-9735869 )
SARS-CoV-2 modulates host translation machinery (R-HSA-9754678 )
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 )
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 )
L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Breast cancer DIS7DPX1 Strong Altered Expression [1]
Breast carcinoma DIS2UE88 Strong Altered Expression [1]
Pancreatic tumour DIS3U0LK Strong Altered Expression [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
10 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [3]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [4]
Estradiol DMUNTE3 Approved Estradiol decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [5]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [6]
Aspirin DM672AH Approved Aspirin increases the expression of Small ribosomal subunit protein uS9 (RPS16). [7]
Haloperidol DM96SE0 Approved Haloperidol decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [8]
Genistein DM0JETC Phase 2/3 Genistein decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [9]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [12]
chloropicrin DMSGBQA Investigative chloropicrin affects the expression of Small ribosomal subunit protein uS9 (RPS16). [13]
AHPN DM8G6O4 Investigative AHPN decreases the expression of Small ribosomal subunit protein uS9 (RPS16). [14]
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⏷ Show the Full List of 10 Drug(s)
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Small ribosomal subunit protein uS9 (RPS16). [10]
TAK-243 DM4GKV2 Phase 1 TAK-243 increases the sumoylation of Small ribosomal subunit protein uS9 (RPS16). [11]
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References

1 MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy.Sci Rep. 2017 Aug 21;7(1):8365. doi: 10.1038/s41598-017-08737-w.
2 Molecular cloning and sequence analysis of the human ribosomal protein S16.J Biol Chem. 1991 Apr 15;266(11):6830-3.
3 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
4 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
5 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
6 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
7 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
8 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
9 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
10 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
11 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
12 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
13 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
14 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.