Details of the Drug Combination

General Information of Drug Combination (ID: DC11CQ8)

• Drug Combination Name: Raloxifene + Epirubicin
• Indication: Melanoma; Status: Investigative [1]
• Component Drugs:
  Raloxifene (DMDKF3M): Small molecular drug
  Epirubicin (DMPDW6T): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: MALME-3M
  Zero Interaction Potency (ZIP) Score: 0.94
  Bliss Independence Score: 5.84
  Loewe Additivity Score: 5.38
  LHighest Single Agent (HSA) Score: 5.35

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Raloxifene

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Approved	[2]

Raloxifene Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[4]

Raloxifene Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Raloxifene Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[6]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[7]
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DEL5N6Y	UD110_HUMAN	Metabolism	[8]

Indication(s) of Epirubicin

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[3]

Epirubicin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[9]

Epirubicin Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[10]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[11]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[11]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[11]

Epirubicin Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[12]

Epirubicin Interacts with 30 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[13]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Increases Expression	[13]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[13]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Response To Substance	[14]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Increases Expression	[15]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[16]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[17]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[18]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Affects Mutagenesis	[19]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Expression	[13]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Increases Phosphorylation	[20]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[20]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[20]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Affects Mutagenesis	[19]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[21]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[16]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[16]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Increases Phosphorylation	[20]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Expression	[21]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases ADR	[22]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Increases Response To Substance	[23]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)	OT9AGAIJ	LHPP_HUMAN	Increases ADR	[22]
Alpha-protein kinase 1 (ALPK1)	OTBW6SGD	ALPK1_HUMAN	Increases ADR	[24]
Baculoviral IAP repeat-containing protein 6 (BIRC6)	OTCQJAB0	BIRC6_HUMAN	Decreases Response To Substance	[25]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Response To Substance	[26]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Affects Response To Substance	[27]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Response To Substance	[28]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Response To Substance	[29]
Little elongation complex subunit 1 (ICE1)	OTOXTBUH	ICE1_HUMAN	Increases ADR	[22]
Microcephalin (MCPH1)	OTYT3TT5	MCPH1_HUMAN	Increases ADR	[24]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult T acute lymphoblastic leukemia	DCISJ8Q	MOLT-4	Investigative	[30]
Astrocytoma	DCD3WUE	U251	Investigative	[30]
Astrocytoma	DC8H8MP	SNB-19	Investigative	[30]
Childhood T acute lymphoblastic leukemia	DC19IIG	CCRF-CEM	Investigative	[30]
Chronic myelogenous leukemia	DCIXE37	K-562	Investigative	[30]
Clear cell renal cell carcinoma	DCABI0R	TK-10	Investigative	[30]
Clear cell renal cell carcinoma	DC2GHEO	786-0	Investigative	[30]
Clear cell renal cell carcinoma	DCNLRXG	CAKI-1	Investigative	[30]
Glioma	DCCUWXC	SF-268	Investigative	[30]
Papillary renal cell carcinoma	DC8RR3G	ACHN	Investigative	[30]
Plasma cell myeloma	DCM3MWU	RPMI-8226	Investigative	[30]
Carcinoma	DC6ISHY	RXF 393	Investigative	[31]
Colon adenocarcinoma	DC5TED2	COLO 205	Investigative	[31]
Invasive ductal carcinoma	DC78E56	HS 578T	Investigative	[31]
Invasive ductal carcinoma	DCVG7XP	T-47D	Investigative	[31]
Invasive ductal carcinoma	DCCBAP2	BT-549	Investigative	[31]
Adenocarcinoma	DCU5FHC	DU-145	Investigative	[1]
Adenocarcinoma	DCTB825	OVCAR3	Investigative	[1]
Adenocarcinoma	DCU07RQ	NCIH23	Investigative	[1]
Adenocarcinoma	DC4H0ZR	A549	Investigative	[1]
Adenocarcinoma	DCLHA8D	HCT-15	Investigative	[1]
Adenocarcinoma	DCVFRMR	SW-620	Investigative	[1]
Amelanotic melanoma	DC26C0L	M14	Investigative	[1]
Cutaneous melanoma	DC9987P	SK-MEL-28	Investigative	[1]
Cutaneous melanoma	DCFCVX6	SK-MEL-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC7OLWZ	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCV3HX5	OVCAR-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCS0D8A	NCI\\/ADR-RES	Investigative	[1]
Large cell lung carcinoma	DCCVQCF	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCGQE06	EKVX	Investigative	[1]
Malignant melanoma	DCMMPZF	UACC62	Investigative	[1]
Melanoma	DC36LNN	SK-MEL-2	Investigative	[1]
Melanoma	DCL9J1V	UACC-257	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DC721N3	IGROV1	Investigative	[1]
Non-small cell lung carcinoma	DCPMI71	HOP-92	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCDNCIA	SK-OV-3	Investigative	[1]
Pleural epithelioid mesothelioma	DC6YN7E	NCI-H226	Investigative	[1]
Prostate carcinoma	DCVBALQ	PC-3	Investigative	[1]

References

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