Details of the Drug Combination

General Information of Drug Combination (ID: DC544CQ)

• Drug Combination Name: Raloxifene + Plicamycin
• Indication: Lung adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Raloxifene (DMDKF3M): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: MDA-MB-231
  Zero Interaction Potency (ZIP) Score: 1.95
  Bliss Independence Score: 10.22
  Loewe Additivity Score: 6.3
  LHighest Single Agent (HSA) Score: 5.79

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Raloxifene

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Approved	[2]

Raloxifene Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[5]

Raloxifene Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Raloxifene Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[7]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[8]
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DEL5N6Y	UD110_HUMAN	Metabolism	[9]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[2]
Testicular cancer	2C80	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[3]
Lung cancer	2C25.0	Investigative	[4]
Ovarian cancer	2C73	Investigative	[4]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[11]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[12]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[13]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[13]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[13]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[14]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[14]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[15]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[10]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[16]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[17]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[18]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[10]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[19]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[16]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[20]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[21]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCUUWEB	HL-60(TB)	Investigative	[22]
Adult T acute lymphoblastic leukemia	DC0VRBE	MOLT-4	Investigative	[22]
Anaplastic large cell lymphoma	DC1HCMI	SR	Investigative	[22]
Childhood T acute lymphoblastic leukemia	DC09HHD	CCRF-CEM	Investigative	[22]
Chronic myelogenous leukemia	DCC6K8Y	K-562	Investigative	[22]
Clear cell renal cell carcinoma	DC22SQP	TK-10	Investigative	[22]
Clear cell renal cell carcinoma	DC7TSFW	786-0	Investigative	[22]
Glioblastoma	DCA7TFM	SNB-75	Investigative	[22]
Glioma	DCIK646	SF-539	Investigative	[22]
Glioma	DCD9V8Q	SF-268	Investigative	[22]
Plasma cell myeloma	DCYSBJ0	RPMI-8226	Investigative	[22]
Renal cell carcinoma	DCOLUJ2	SN12C	Investigative	[22]
Breast adenocarcinoma	DCZHEKG	MDA-MB-468	Investigative	[23]
Carcinoma	DC51BBS	RXF 393	Investigative	[23]
Colon adenocarcinoma	DCPFTMU	COLO 205	Investigative	[23]
Colon carcinoma	DCBQOVE	KM12	Investigative	[23]
Invasive ductal carcinoma	DCIGNV8	HS 578T	Investigative	[23]
Invasive ductal carcinoma	DCCFFCC	BT-549	Investigative	[23]
Adenocarcinoma	DCE8N9U	NCIH23	Investigative	[1]
Adenocarcinoma	DCUM9M6	A549	Investigative	[1]
Adenocarcinoma	DCOUZUT	HCT116	Investigative	[1]
Adenocarcinoma	DC1D11H	SW-620	Investigative	[1]
Adenocarcinoma	DCRYFOB	HCC-2998	Investigative	[1]
Adenocarcinoma	DC3GRGR	HT29	Investigative	[1]
Amelanotic melanoma	DCVAQVT	M14	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCXINQ3	OVCAR-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC1ABVZ	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCFPRDH	NCI\\/ADR-RES	Investigative	[1]
Large cell lung carcinoma	DCAUQ1P	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCDWJ9S	HOP-62	Investigative	[1]
Lung adenocarcinoma	DCFK2GI	NCI-H522	Investigative	[1]
Malignant melanoma	DCBYAET	LOX IMVI	Investigative	[1]
Melanoma	DC0E3AZ	SK-MEL-2	Investigative	[1]
Pleural epithelioid mesothelioma	DCXL4SY	NCI-H226	Investigative	[1]
Prostate carcinoma	DC10ZO1	PC-3	Investigative	[1]

References

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