Details of the Drug Combination

General Information of Drug Combination (ID: DCQ1JJP)

Drug Combination Name
Methylene blue Vitamin C
Indication
Disease Entry Status REF
Coronavirus Disease 2019 (COVID-19) Phase 1 [1]
Component Drugs Methylene blue   DMJAPE7 Vitamin C   DMXJ7O8
N.A. Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Methylene blue
Disease Entry ICD 11 Status REF
Acquired methemoglobinemia 3A93 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [1]
Methylene blue Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Monoamine oxidase (MAO) TT32XQJ NOUNIPROTAC . [12]
Guanylate cyclase (GC) TT6HPVC NOUNIPROTAC Inhibitor [13]
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Methylene blue Interacts with 7 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Decreases Activity [14]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [15]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Increases Expression [16]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Increases Activity [17]
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Decreases Activity [18]
6-phosphogluconate dehydrogenase, decarboxylating (PGD) OTVG296F 6PGD_HUMAN Increases Activity [17]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases ADR [19]
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⏷ Show the Full List of 7 DOT(s)
Indication(s) of Vitamin C
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [3]
Carcinoma 2A00-2F9Z Approved [4]
Coagulation defect 3B10.0 Approved [5]
Desmoplastic small round cell tumor N.A. Approved [6]
Plasma cell myeloma 2A83.1 Approved [7]
Refractory plasma cell neoplasm N.A. Approved [8]
Shock MG40 Approved [9]
Vitamin C deficiency 5B56 Approved [10]
Vitamin deficiency 5B55-5B71 Approved [11]
Urinary tract infection GC08 Phase 2 [10]
Vitamin C Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Solute carrier family 23 member 2 (SLC23A2) TTOP832 S23A2_HUMAN Modulator [24]
Solute carrier family 23 member 1 (SLC23A1) TT6XAGK S23A1_HUMAN Modulator [25]
Collagen (CO) TTK982E NOUNIPROTAC Activator [26]
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Vitamin C Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Sodium-dependent vitamin C transporter 1 (SLC23A1) DT3KH2X S23A1_HUMAN Substrate [27]
Sodium-dependent vitamin C transporter 2 (SLC23A2) DTVY9PJ S23A2_HUMAN Substrate [28]
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Vitamin C Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Metabolism [29]
Prolyl 4-hydroxylase alpha-2 (P4HA2) DE5EGK0 P4HA2_HUMAN Metabolism [30]
Prolyl 4-hydroxylase alpha-1 (P4HA1) DESO5ZY P4HA1_HUMAN Metabolism [30]
HIF-prolyl hydroxylase 2 (EGLN1) DEWO724 EGLN1_HUMAN Metabolism [31]
Prolyl 4-hydroxylase alpha-3 (P4HA3) DE2L4RX P4HA3_HUMAN Metabolism [32]
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Vitamin C Interacts with 119 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Decreases Expression [20]
Solute carrier family 23 member 1 (SLC23A1) OTE6F9U6 S23A1_HUMAN Increases Expression [33]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Activity [34]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Decreases Activity [35]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [36]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Decreases Activity [36]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Activity [36]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Increases Expression [37]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Increases Expression [37]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Increases Expression [37]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [20]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [20]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [20]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [20]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Decreases Expression [20]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [20]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [20]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Decreases Expression [20]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Decreases Expression [20]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [20]
Cystathionine beta-synthase (CBS) OT46FSKD CBS_HUMAN Decreases Expression [20]
Stress-70 protein, mitochondrial (HSPA9) OT4TMVS9 GRP75_HUMAN Decreases Expression [20]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Decreases Expression [20]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Decreases Expression [20]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Decreases Expression [20]
Eukaryotic initiation factor 4A-I (EIF4A1) OTMTBX6N IF4A1_HUMAN Decreases Expression [20]
Protein disulfide-isomerase A2 (PDIA2) OTC2WMXS PDIA2_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 3 subunit A (EIF3A) OTFABY9G EIF3A_HUMAN Decreases Expression [20]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Decreases Expression [20]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Decreases Expression [20]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [20]
Structural maintenance of chromosomes protein 6 (SMC6) OT3IBHQD SMC6_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 3 subunit C (EIF3C) OTR8RF9X EIF3C_HUMAN Decreases Expression [20]
Lysyl oxidase homolog 2 (LOXL2) OTRT46B5 LOXL2_HUMAN Decreases Expression [20]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Activity [38]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Decreases Expression [39]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Decreases Expression [39]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [40]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Decreases Expression [40]
Phosphoribosylformylglycinamidine synthase (PFAS) OTCOBYYK PUR4_HUMAN Increases Expression [21]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) OTY3TQYA PAPS1_HUMAN Decreases Expression [21]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [21]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Increases Expression [21]
Glypican-1 (GPC1) OTQKRSSV GPC1_HUMAN Increases Expression [21]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Increases Expression [21]
Elongator complex protein 6 (ELP6) OT0T3BLP ELP6_HUMAN Decreases Expression [21]
Protocadherin Fat 1 (FAT1) OTF174DH FAT1_HUMAN Increases Expression [21]
Putative PRAME family member 13 (PRAMEF13) OTVJTEXT PRA13_HUMAN Increases Expression [21]
C-Maf-inducing protein (CMIP) OTZN8Z4A CMIP_HUMAN Increases Expression [21]
Prolyl 3-hydroxylase OGFOD1 (OGFOD1) OTTUQ5O3 OGFD1_HUMAN Decreases Expression [21]
Autism susceptibility gene 2 protein (AUTS2) OTAEXHSC AUTS2_HUMAN Increases Expression [21]
Ester hydrolase C11orf54 (C11ORF54) OT5B6EU8 CK054_HUMAN Decreases Expression [21]
Ketosamine-3-kinase (FN3KRP) OT9HR05S KT3K_HUMAN Increases Expression [21]
GPN-loop GTPase 1 (GPN1) OTM03SFL GPN1_HUMAN Decreases Expression [21]
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) OTJJOI2B TOM7_HUMAN Decreases Expression [21]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [41]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Increases Expression [41]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [41]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [41]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Increases Expression [42]
Integrin-binding sialoprotein (IBSP) OT29944Y SIAL_HUMAN Increases Expression [42]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [42]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [43]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [44]
Adenylate cyclase type 6 (ADCY6) OTFOY4WW ADCY6_HUMAN Decreases Expression [45]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Expression [46]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [47]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [44]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [48]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [46]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [48]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Decreases Expression [49]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [50]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Expression [47]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [50]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [47]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [44]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [44]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [51]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Affects Expression [50]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [44]
Xaa-Pro dipeptidase (PEPD) OT3LFY7S PEPD_HUMAN Increases Activity [52]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Affects Expression [50]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Increases Activity [53]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Reduction [54]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Decreases Expression [44]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [44]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Affects Expression [22]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Decreases Expression [44]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Affects Expression [22]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [22]
Signal transducer and activator of transcription 6 (STAT6) OTCKMP49 STAT6_HUMAN Affects Expression [22]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [22]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Increases Expression [55]
Natural resistance-associated macrophage protein 2 (SLC11A2) OTMEUHE8 NRAM2_HUMAN Decreases Expression [56]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Response To Substance [57]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Decreases Activity [58]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Increases Expression [59]
C-X-C motif chemokine 6 (CXCL6) OTFTCQ4O CXCL6_HUMAN Increases Expression [50]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Decreases Expression [60]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [55]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Increases Expression [61]
Transcription factor Sp4 (SP4) OTWB30IZ SP4_HUMAN Decreases Expression [44]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Decreases Expression [44]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Metabolism [46]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Activity [43]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [59]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [22]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [59]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Degradation [62]
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) OTUTVBES CYBR1_HUMAN Decreases Expression [56]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Decreases Expression [46]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Increases Expression [63]
Haptoglobin (HP) OTGUGAF9 HPT_HUMAN Affects Response To Substance [64]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Oxidation [65]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Transport [66]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Affects Response To Substance [67]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [67]
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⏷ Show the Full List of 119 DOT(s)

References

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