Details of the Drug Combination

General Information of Drug Combination (ID: DCQUMVY)

Drug Combination Name
Raloxifene TEM
Indication
Disease Entry Status REF
Glioma Investigative [1]
Component Drugs Raloxifene   DMDKF3M TEM   DMLNFWU
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SF-268
Zero Interaction Potency (ZIP) Score: 2.34
Bliss Independence Score: 3.88
Loewe Additivity Score: 1.41
LHighest Single Agent (HSA) Score: 0.26

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Raloxifene
Disease Entry ICD 11 Status REF
Osteoporosis FB83.0 Approved [2]
Raloxifene Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Modulator [4]
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Raloxifene Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]
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Raloxifene Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [7]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DEL5N6Y UD110_HUMAN Metabolism [8]
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Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [3]

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Astrocytoma DCG43CY U251 Investigative [1]
Astrocytoma DC0KG0L SNB-19 Investigative [1]
Glioblastoma DCWDEO8 SNB-75 Investigative [1]
Glioma DCED6J0 SF-295 Investigative [1]
Carcinoma DCF6RVK MCF7 Investigative [9]
Invasive ductal carcinoma DC1VYFU BT-549 Investigative [9]
Invasive ductal carcinoma DCX877Y T-47D Investigative [9]
Invasive ductal carcinoma DCYGTWQ HS 578T Investigative [9]
Adenocarcinoma DC4IYD7 DU-145 Investigative [10]
Adenocarcinoma DCIZ8SE NCIH23 Investigative [10]
Adenocarcinoma DC56MDP SW-620 Investigative [10]
Adenocarcinoma DC7RDYV HT29 Investigative [10]
Cutaneous melanoma DCPUUVE SK-MEL-28 Investigative [10]
Lung adenocarcinoma DCLIT6X EKVX Investigative [10]
Lung adenocarcinoma DC40Y6C HOP-62 Investigative [10]
Malignant melanoma DCOV55H UACC62 Investigative [10]
Melanoma DC6KGS7 SK-MEL-2 Investigative [10]
Prostate carcinoma DC5PAP6 PC-3 Investigative [10]
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⏷ Show the Full List of 18 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
5 Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. Transl Res. 2012 Oct;160(4):298-308.
6 The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab Dispos. 2006 Dec;34(12):2073-8.
7 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
8 Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. Cancer Prev Res (Phila). 2013 Jul;6(7):719-30.
9 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
10 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.