Details of the Drug Combination

General Information of Drug Combination (ID: DCXXD9Y)

• Drug Combination Name: Cabazitaxel + Plicamycin
• Indication: Melanoma; Status: Investigative [1]
• Component Drugs:
  Cabazitaxel (DMPAZHC): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: UACC-257
  Zero Interaction Potency (ZIP) Score: 25.06
  Bliss Independence Score: 20.62
  Loewe Additivity Score: 11.82
  LHighest Single Agent (HSA) Score: 21.57

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Cabazitaxel

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Metastatic prostate carcinoma	N.A.	Investigative	[3]

Cabazitaxel Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[7]

Cabazitaxel Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[8]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[8]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[8]

Cabazitaxel Interacts with 2 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Expression	[9]
Proline-rich AKT1 substrate 1 (AKT1S1)	OT4JHN4Y	AKTS1_HUMAN	Decreases Expression	[9]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[4]
Testicular cancer	2C80	Approved	[4]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[5]
Lung cancer	2C25.0	Investigative	[6]
Ovarian cancer	2C73	Investigative	[6]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[11]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[12]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[13]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[13]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[13]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[14]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[14]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[15]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[10]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[16]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[17]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[18]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[10]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[19]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[16]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[20]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[21]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DC6MA2T	HCC-2998	Investigative	[1]
Adult acute myeloid leukemia	DCFKIO7	HL-60(TB)	Investigative	[1]
Adult T acute lymphoblastic leukemia	DCW4KUL	MOLT-4	Investigative	[1]
Anaplastic large cell lymphoma	DC7912S	SR	Investigative	[1]
Astrocytoma	DCBSFP9	U251	Investigative	[1]
Astrocytoma	DCARKRK	SNB-19	Investigative	[1]
Childhood T acute lymphoblastic leukemia	DCQLT1P	CCRF-CEM	Investigative	[1]
Clear cell renal cell carcinoma	DC3APSN	A498	Investigative	[1]
Clear cell renal cell carcinoma	DC88NCY	786-0	Investigative	[1]
Cutaneous melanoma	DCRN3ZN	SK-MEL-28	Investigative	[1]
Cutaneous melanoma	DCZ6FN5	SK-MEL-5	Investigative	[1]
Glioblastoma	DCZHY12	SNB-75	Investigative	[1]
Glioma	DCD4UUV	SF-539	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCY037T	OVCAR-8	Investigative	[1]
Lung adenocarcinoma	DCQ2IHU	MDA-MB-231	Investigative	[1]
Malignant melanoma	DC747PX	UACC62	Investigative	[1]
Non-small cell lung carcinoma	DCBS5KM	HOP-92	Investigative	[1]
Papillary renal cell carcinoma	DC4GTW3	ACHN	Investigative	[1]
Breast adenocarcinoma	DCBLV1H	MDA-MB-468	Investigative	[22]
Carcinoma	DCASK5E	MCF7	Investigative	[22]
Invasive ductal carcinoma	DC7Z603	T-47D	Investigative	[22]
Invasive ductal carcinoma	DCI8H5T	HS 578T	Investigative	[22]
Invasive ductal carcinoma	DCBZD4E	BT-549	Investigative	[22]

References

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