Details of the Drug Combinations

General Information of This Drug (ID: DM30SGU)

Drug Name
Simvastatin   DM30SGU
Synonyms
Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lipovas; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatina; Simvastatine; Simvastatinum; Sinvacor; Sivastin; Synvinolin; Vasotenal; Zocor; Zocord; Simvast CR; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; MK 0733; MK 733; MK733; TNP00259; DRG-0320; KS-1113; L 644128-000U; MK-0733; MK-733; Simcard (TN); Simlup (TN); Simvacor (TN); Simvastatin & Primycin; Simvastatin, Compactin; Zocor (TN); Simvastatin [USAN:INN:BAN]; Simvastatin (JAN/USP/INN); Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta; 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Approved [1]
Atherosclerosis BD40 Approved [1]
Coronary heart disease BA80.Z Approved [1]
Cystic fibrosis CA25 Approved [1]
Depression 6A70-6A7Z Approved [1]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia 5C80.Z Approved [1]
Hyperlipidemia, familial combined, LPL related N.A. Approved [1]
Hypertriglyceridemia 5C80.1 Approved [1]
Pneumonia CA40 Approved [1]
Primary hypercholesterolemia 5C80.00 Approved [1]
Prostate carcinoma N.A. Approved [1]
Rhinitis FA20 Approved [1]
Type-1/2 diabetes 5A10-5A11 Approved [1]
Stroke 8B20 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticholesteremic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Simvastatin + Idarubicin DCU0FJ5 Idarubicin Glioblastoma? (Cell Line: T98G) [3]
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43 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
AKB-6548 + Simvastatin DC2DVIE AKB-6548 Drug Interaction Potentiation [4]
Gefitinib + Simvastatin DCNVKWM Gefitinib Lung Cancer [5]
Simvastatin + Atorvastatin DCFE6EK Atorvastatin Hypercholesterolemia [6]
Simvastatin + Atorvastatin DCYILLX Atorvastatin Diabetes Mellitus, Type 2 [7]
Simvastatin + Metformin DC0CIQP Metformin Prostate Carcinoma [8]
Simvastatin + Fenofibrate DC0JWR7 Fenofibrate Dyslipidemia [9]
Simvastatin + Lisinopril DC1DARC Lisinopril Diabetic Nephropathy [10]
Simvastatin + Ezetimibe DC27S5C Ezetimibe Coronary Heart Disease [11]
Simvastatin + Anastrozole DC2G07J Anastrozole Breast Cancer [12]
Simvastatin + Eslicarbazepine acetate DC3R1DP Eslicarbazepine acetate Epilepsy [13]
Simvastatin + Nifedipine DCBBMZT Nifedipine Diabetic Nephropathy [10]
Simvastatin + Ezetimibe DCEYXLT Ezetimibe Kidney Disease, Chronic [14]
Simvastatin + Valsartan DCFR2FF Valsartan Hypertension [15]
Simvastatin + Fostamatinib DCH0Q7G Fostamatinib Rheumatoid Arthritis [16]
Simvastatin + Olanzapine DCIXI2O Olanzapine Schizophrenia [17]
Simvastatin + Atorvastatin DCJPS75 Atorvastatin Atherosclerosis [18]
Simvastatin + Rosiglitazone DCLMIB8 Rosiglitazone Pre-diabetes [19]
Simvastatin + Aspirin DCN066Z Aspirin Hypertriglyceridemia [20]
Simvastatin + SB-649868 DCNXCCJ SB-649868 Sleep Disorders [21]
Simvastatin + Entecavir DCOTVPH Entecavir Hepatitis B [22]
Simvastatin + Dapagliflozin DCU9DT5 Dapagliflozin Type 2 Diabetes Mellitus [23]
Simvastatin + Aspirin DCUMD48 Aspirin Hypertension, Pulmonary [24]
Simvastatin + Afatinib DCZKM1P Afatinib Non-small Cell Lung Cancer [25]
Simvastatin + Rosiglitazone DC7M4N9 Rosiglitazone Type-2 diabetes [26]
Simvastatin + Fenofibrate DCDI8VM Fenofibrate Hyperlipidaemia [27]
Simvastatin + Metformin DC0A32A Metformin Advanced Pancreatic Cancer [28]
Simvastatin + Voclosporin DC3YCER Voclosporin Drug-drug Interaction [29]
Simvastatin + Letrozole DC8LAUF Letrozole Anatomic Stage I Breast Cancer AJCC v8 [30]
Simvastatin + Dexamethasone DC9AEJU Dexamethasone Lymphoma [31]
Simvastatin + Gemcabene DCIMXJL Gemcabene Hypercholesterolemia [32]
Simvastatin + CATECHIN DCT3SFI CATECHIN Dyslipidemias [33]
Tenofovir + Simvastatin DC6LVM9 Tenofovir Hepatitis B [22]
Ruxolitinib + Simvastatin DCG7O1S Ruxolitinib Coronavirus Disease 2019 (COVID-19) [34]
Simvastatin + Rifaximin DC47PP4 Rifaximin Cirrhoses, Liver [35]
Simvastatin + Rifaximin DCNO4DX Rifaximin Liver Cirrhoses [36]
Simvastatin + Atorvastatin DC6TWJR Atorvastatin Hypercholesterolemia [37]
Simvastatin + Aspirin DCFJ0RA Aspirin Covid-19 [38]
Simvastatin + Losartan DCNU742 Losartan Covid-19 [38]
Simvastatin + Perphenazine DC39P8D Perphenazine Schizophrenia [39]
Simvastatin + Metformin DC3A86Q Metformin Schizophrenia [39]
Simvastatin + Aripiprazole DCWS36N Aripiprazole Schizophrenia [39]
Simvastatin + Losartan DCOKJ0J Losartan Serious Mental Illness [40]
Simvastatin + Methotrexate DCYGZL1 Methotrexate Arthritis, Rheumatoid [41]
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⏷ Show the Full List of 43 DrugCom(s)

References

1 Simvastatin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2955).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT03801733) Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin
5 ClinicalTrials.gov (NCT00452244) Gefitinib With or Without Simvastatin in Non-Small Cell Lung Cancer (NSCLC)
6 ClinicalTrials.gov (NCT02518516) High Potency Statins and Acute Kidney Injury
7 ClinicalTrials.gov (NCT02518503) High Potency Statins and the Risk of Diabetes
8 ClinicalTrials.gov (NCT01561482) Study of Metformin With Simvastatin for Men With Prostate Carcinoma
9 ClinicalTrials.gov (NCT00300456) Evaluate Safety and Efficacy of ABT-335 in Combination With Simvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood
10 ClinicalTrials.gov (NCT00004266) Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes
11 ClinicalTrials.gov (NCT00481351) Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons
12 ClinicalTrials.gov (NCT00354640) Simvastatin and Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ or Invasive Breast Cancer
13 ClinicalTrials.gov (NCT00987558) Effect of Repeated Administration of Eslicarbazepine Acetate on the Pharmacokinetics of Simvastatin in Healthy Subjects
14 ClinicalTrials.gov (NCT00125593) Study of Heart and Renal Protection
15 ClinicalTrials.gov (NCT00738972) Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168)
16 ClinicalTrials.gov (NCT01725230) Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With Fostamatinib
17 ClinicalTrials.gov (NCT00672464) Cardio Risk of Acute Schizophrenia Olanzapine Duke
18 ClinicalTrials.gov (NCT00166530) EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)
19 ClinicalTrials.gov (NCT00831129) A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs
20 ClinicalTrials.gov (NCT01486433) The Effect of Multiple Doses of Epanova on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects
21 ClinicalTrials.gov (NCT01299597) A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.
22 ClinicalTrials.gov (NCT00994773) Simvastatin for the Treatment of Chronic Hepatitis B
23 ClinicalTrials.gov (NCT00839683) Pharmacokinetic Drug Interaction Study of Dapagliflozin and Valsartan or Simvastatin in Healthy Subjects
24 ClinicalTrials.gov (NCT00384865) A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
25 ClinicalTrials.gov (NCT01156545) BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC
26 Clinical pipeline report, company report or official report of GlaxoSmithKline.
27 ClinicalTrials.gov (NCT01674712) A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease. U.S. National Institutes of Health.
28 ClinicalTrials.gov (NCT03889795) Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
29 ClinicalTrials.gov (NCT05306379) Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin
30 ClinicalTrials.gov (NCT05464810) Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
31 ClinicalTrials.gov (NCT04514029) Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel
32 ClinicalTrials.gov (NCT02587390) Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy Volunteers
33 ClinicalTrials.gov (NCT02431013) Cilostazol-Simvastatin Drug Interaction Study
34 ClinicalTrials.gov (NCT04348695) Study of Ruxolitinib Plus Simvastatin in the Prevention and Treatment of Respiratory Failure of COVID-19.. U.S. National Institutes of Health.
35 ClinicalTrials.gov (NCT03150459) Simvastatin Plus Rifaximin in Decompensated Cirrhosis
36 ClinicalTrials.gov (NCT03780673) Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development
37 ClinicalTrials.gov (NCT00664469) INdians Followed for INtensive Lipid Lowering Treatment and Its safetY
38 ClinicalTrials.gov (NCT04343001) Coronavirus Response - Active Support for Hospitalised Covid-19 Patients. U.S. National Institutes of Health.
39 ClinicalTrials.gov (NCT00802100) Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia
40 ClinicalTrials.gov (NCT02188121) Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
41 ClinicalTrials.gov (NCT04177173) Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid Arthritis