Details of the Drug Combination

General Information of Drug Combination (ID: DCUMD48)

Drug Combination Name
Simvastatin Aspirin
Indication
Disease Entry Status REF
Hypertension, Pulmonary Phase 1 [1]
Component Drugs Simvastatin   DM30SGU Aspirin   DM672AH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Simvastatin
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Approved [2]
Atherosclerosis BD40 Approved [2]
Coronary heart disease BA80.Z Approved [2]
Cystic fibrosis CA25 Approved [2]
Depression 6A70-6A7Z Approved [2]
Hypercholesterolaemia 5C80.0 Approved [3]
Hyperlipidemia 5C80.Z Approved [2]
Hyperlipidemia, familial combined, LPL related N.A. Approved [2]
Hypertriglyceridemia 5C80.1 Approved [2]
Pneumonia CA40 Approved [2]
Primary hypercholesterolemia 5C80.00 Approved [2]
Prostate carcinoma N.A. Approved [2]
Rhinitis FA20 Approved [2]
Type-1/2 diabetes 5A10-5A11 Approved [2]
Stroke 8B20 Investigative [2]
Simvastatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [11]
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Simvastatin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [13]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [14]
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Simvastatin Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [16]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [17]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [18]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [19]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [16]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [16]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [16]
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⏷ Show the Full List of 8 DME(s)
Simvastatin Interacts with 264 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [20]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [21]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Response To Substance [22]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Response To Substance [23]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [24]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [25]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Response To Substance [26]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Response To Substance [27]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Activity [24]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [28]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [28]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [28]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [29]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Expression [29]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [29]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [29]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Decreases Expression [29]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Expression [8]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [8]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [8]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Decreases Expression [8]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [8]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [8]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [8]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [8]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Increases Expression [8]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Expression [8]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [8]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [8]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Decreases Expression [8]
Keratin, type I cytoskeletal 13 (KRT13) OTTYSKGX K1C13_HUMAN Increases Expression [8]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Increases Expression [8]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [8]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [8]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [8]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [8]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Increases Expression [8]
Calmodulin-like protein 3 (CALML3) OTM8DNQU CALL3_HUMAN Increases Expression [8]
Gap junction beta-2 protein (GJB2) OTBKLEYB CXB2_HUMAN Increases Expression [8]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [8]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Increases Expression [8]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [8]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Increases Expression [8]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [8]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [8]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [8]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [8]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [8]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Increases Expression [8]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Increases Expression [8]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [8]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Activity [8]
Lymphotoxin-beta (LTB) OTUFS8CF TNFC_HUMAN Decreases Expression [8]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [8]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [8]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [8]
Rho GTPase-activating protein 29 (ARHGAP29) OT8JH4TY RHG29_HUMAN Decreases Expression [8]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [8]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [8]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [8]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Expression [8]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [8]
Spondin-2 (SPON2) OTE7JLNM SPON2_HUMAN Increases Expression [8]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [8]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [8]
Matrix metalloproteinase-28 (MMP28) OTHQZXM1 MMP28_HUMAN Increases Expression [8]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Decreases Expression [8]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [8]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Increases Expression [8]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Activity [30]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Localization [31]
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) OT6GWW1P NPCL1_HUMAN Decreases Expression [32]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [33]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Expression [33]
Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) OTX31RLZ KI2S2_HUMAN Decreases Expression [33]
Killer cell lectin-like receptor subfamily F member 1 (KLRF1) OTGHZ7FU KLRF1_HUMAN Decreases Expression [33]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Phosphorylation [34]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Nitrosation [34]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Phosphorylation [34]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Increases Expression [35]
Sphingosine 1-phosphate receptor 1 (S1PR1) OTLTXDQT S1PR1_HUMAN Increases Expression [36]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [37]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [38]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Secretion [39]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [40]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [41]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Increases Expression [41]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [42]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [42]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [43]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [44]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [45]
Suppressor of cytokine signaling 7 (SOCS7) OT503VJG SOCS7_HUMAN Increases Expression [46]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [46]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [47]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [48]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [49]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [50]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [45]
Alpha-actinin-4 (ACTN4) OTCNZAJ5 ACTN4_HUMAN Increases Expression [51]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Degradation [52]
Nephrin (NPHS1) OT21JD3P NPHN_HUMAN Increases Expression [51]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [43]
Apolipoprotein M (APOM) OTI3FQQC APOM_HUMAN Decreases Expression [53]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [54]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [55]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [56]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [57]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [58]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Prenylation [59]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Decreases Activity [60]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [61]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Activity [62]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Expression [46]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [46]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [63]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [64]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [65]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Expression [66]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [67]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Increases Expression [68]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Affects Expression [43]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [69]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Secretion [70]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Activity [71]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [72]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [73]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [74]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Activity [75]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [76]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Increases Expression [46]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [77]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Affects Expression [78]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [79]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [80]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [76]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Localization [81]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [82]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Increases Expression [55]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [83]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [84]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [85]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Increases Expression [55]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Activity [86]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [87]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [88]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [45]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [79]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [89]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [90]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Affects Expression [91]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [83]
Cholesteryl ester transfer protein (CETP) OTAGPPOE CETP_HUMAN Decreases Expression [92]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [93]
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Increases Expression [94]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [79]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [95]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [96]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Affects Expression [63]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Activity [97]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Increases Expression [98]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Affects Localization [45]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [73]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [99]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Increases Expression [55]
Cytotoxic T-lymphocyte protein 4 (CTLA4) OTYQR611 CTLA4_HUMAN Decreases Expression [46]
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Decreases Expression [100]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Increases Expression [65]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [76]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Expression [98]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Decreases Expression [101]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [46]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [93]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [43]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Decreases Expression [46]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [102]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [71]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [71]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [103]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Affects Expression [104]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Affects Expression [63]
Type-1 angiotensin II receptor (AGTR1) OT2NRMJP AGTR1_HUMAN Decreases Expression [105]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Increases Activity [106]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [107]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [84]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [108]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [58]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Activity [109]
C-C chemokine receptor type 2 (CCR2) OTQ7T10J CCR2_HUMAN Decreases Expression [110]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [43]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [111]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [112]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Expression [101]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Decreases Expression [54]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [113]
CX3C chemokine receptor 1 (CX3CR1) OTIM9XT8 CX3C1_HUMAN Decreases Expression [114]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [115]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Expression [91]
Nuclear receptor ROR-gamma (RORC) OTUBFRPC RORG_HUMAN Decreases Expression [46]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Decreases Expression [95]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [116]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Activity [117]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) OT2TTZPZ CDN2D_HUMAN Increases Expression [93]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Affects Localization [45]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Increases Expression [55]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Expression [118]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Activity [71]
Rho GTPase-activating protein 4 (ARHGAP4) OTXV053R RHG04_HUMAN Increases Expression [55]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Increases Expression [91]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Affects Localization [84]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Phosphorylation [119]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [43]
Myosin light chain 5 (MYL5) OT7CQ24K MYL5_HUMAN Increases Expression [65]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Decreases Expression [55]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [89]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [50]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [120]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Decreases Localization [117]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [47]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) OTYOORME NFAC3_HUMAN Decreases Localization [121]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Increases Expression [65]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [50]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [45]
Bone morphogenetic protein receptor type-2 (BMPR2) OTM9W547 BMPR2_HUMAN Increases Stability [122]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [87]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Affects Localization [55]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Degradation [52]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [123]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [124]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Decreases Expression [47]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Decreases Expression [46]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [9]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [74]
Interleukin-27 subunit alpha (IL27) OTIS3OF8 IL27A_HUMAN Increases Expression [46]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Increases Expression [125]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Phosphorylation [117]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Increases Expression [55]
Interleukin-17F (IL17F) OT9W9DE0 IL17F_HUMAN Decreases Secretion [124]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Decreases Expression [125]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Expression [47]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [49]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Expression [98]
Interleukin-22 (IL22) OTW31FU9 IL22_HUMAN Decreases Secretion [124]
Interleukin-21 (IL21) OTABCY4W IL21_HUMAN Decreases Expression [46]
Podocin (NPHS2) OTLCNUII PODO_HUMAN Increases Expression [51]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [46]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [45]
Dentin sialophosphoprotein (DSPP) OT1TYNDN DSPP_HUMAN Increases Expression [126]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Affects Expression [78]
CD2-associated protein (CD2AP) OTC76KQM CD2AP_HUMAN Increases Expression [51]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Affects Response To Substance [127]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Increases Response To Substance [128]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [39]
Leptin receptor (LEPR) OT9H7G0C LEPR_HUMAN Affects Response To Substance [129]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases ADR [25]
Small ribosomal subunit protein mS31 (MRPS31) OTB0OBWK RT31_HUMAN Decreases Response To Substance [130]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [130]
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) OTCVXOD6 SCAP_HUMAN Affects Response To Substance [131]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases ADR [132]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Response To Substance [130]
5-hydroxytryptamine receptor 3B (HTR3B) OTMGIYRE 5HT3B_HUMAN Increases Response To Substance [128]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Decreases Response To Substance [130]
------------------------------------------------------------------------------------
⏷ Show the Full List of 264 DOT(s)
Indication(s) of Aspirin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [4]
Adenomatous colon polyp N.A. Approved [4]
Back pain ME84.Z Approved [4]
Common cold CA00 Approved [4]
Headache 8A80-8A84 Approved [4]
Migraine disorder N.A. Approved [4]
Myocardial infarction BA41-BA43 Approved [5]
Osteoarthritis FA00-FA05 Approved [4]
Pain MG30-MG3Z Approved [6]
Cardiovascular disease BA00-BE2Z Phase 3 [6]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [7]
Colon cancer 2B90.Z Investigative [4]
Aspirin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [144]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [5]
------------------------------------------------------------------------------------
Aspirin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [145]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [146]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [147]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [148]
------------------------------------------------------------------------------------
Aspirin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [149]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [150]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [151]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [152]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Metabolism [151]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Metabolism [151]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 DME(s)
Aspirin Interacts with 513 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Affects Response To Substance [151]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Affects Response To Substance [153]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [154]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [155]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases ADR [156]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases ADR [156]
Leukotriene C4 synthase (LTC4S) OT3XNFJZ LTC4S_HUMAN Affects Response To Substance [157]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [158]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Decreases Response To Substance [159]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [160]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [161]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases ADR [162]
Testis-expressed basic protein 1 (TSBP1) OT5GE8IO TSBP1_HUMAN Increases ADR [163]
Thromboxane A2 receptor (TBXA2R) OT9CIHQ5 TA2R_HUMAN Decreases Response To Substance [164]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases ADR [163]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Affects Response To Substance [165]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Increases ADR [166]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases ADR [25]
Laminin subunit alpha-1 (LAMA1) OTQZMP86 LAMA1_HUMAN Increases ADR [167]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Increases ADR [163]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Increases Expression [133]
Anoctamin-9 (ANO9) OTQ2UM3M ANO9_HUMAN Increases Expression [133]
PH and SEC7 domain-containing protein 1 (PSD) OTUZIXUZ PSD1_HUMAN Increases Expression [133]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [133]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Increases Expression [133]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Increases Expression [133]
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) OT4AVU95 MYPT1_HUMAN Decreases Expression [133]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Increases Expression [133]
Origin recognition complex subunit 4 (ORC4) OT3ACTST ORC4_HUMAN Increases Expression [133]
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) OT5FL0WU PLPL9_HUMAN Increases Expression [133]
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) OTSQGLSB TI17B_HUMAN Increases Expression [133]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Increases Expression [133]
Astrotactin-2 (ASTN2) OTF0W2FJ ASTN2_HUMAN Increases Expression [133]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [133]
Sperm-associated antigen 6 (SPAG6) OTVVG3Q0 SPAG6_HUMAN Increases Expression [133]
Trafficking protein particle complex subunit 6A (TRAPPC6A) OT0ZRV5C TPC6A_HUMAN Increases Expression [133]
DNA topoisomerase 3-beta-1 (TOP3B) OTNFEUOO TOP3B_HUMAN Increases Expression [133]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [133]
Salivary acidic proline-rich phosphoprotein 1/2 (PRH1) OTQZ6HX0 PRPC_HUMAN Decreases Expression [133]
Ribonuclease pancreatic (RNASE1) OTKZ7CO9 RNAS1_HUMAN Increases Expression [133]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Increases Expression [133]
Ras-related protein Ral-B (RALB) OTFH203X RALB_HUMAN Decreases Expression [133]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [133]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Decreases Expression [133]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [133]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases Expression [133]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Increases Expression [133]
DNA excision repair protein ERCC-5 (ERCC5) OTQAKFJM ERCC5_HUMAN Increases Expression [133]
Neuroendocrine convertase 1 (PCSK1) OTPBRJ54 NEC1_HUMAN Decreases Expression [133]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [133]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [133]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [133]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [133]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Decreases Expression [133]
Transcription initiation factor TFIID subunit 6 (TAF6) OTY1Z9C4 TAF6_HUMAN Decreases Expression [133]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Decreases Expression [133]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Increases Expression [133]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [133]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) OT21PY3J NDST2_HUMAN Increases Expression [133]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [133]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Decreases Expression [133]
Small ubiquitin-related modifier 3 (SUMO3) OTTUJQJ1 SUMO3_HUMAN Increases Expression [133]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [133]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Decreases Expression [133]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [133]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Decreases Expression [133]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Decreases Expression [133]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Increases Expression [133]
General transcription factor II-I (GTF2I) OTUYL1TQ GTF2I_HUMAN Decreases Expression [133]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Increases Expression [133]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Decreases Expression [133]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Decreases Expression [133]
Sodium channel subunit beta-1 (SCN1B) OTGD78J3 SCN1B_HUMAN Increases Expression [133]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) OTU1AIEW VPP3_HUMAN Increases Expression [133]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Decreases Expression [133]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Decreases Expression [133]
TBC1 domain family member 10B (TBC1D10B) OT5MVCI5 TB10B_HUMAN Increases Expression [133]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Increases Expression [133]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [133]
DENN domain-containing protein 5A (DENND5A) OT0QNNY1 DEN5A_HUMAN Increases Expression [133]
Kinesin-like protein KIF21A (KIF21A) OT511XD9 KI21A_HUMAN Increases Expression [133]
Calcium-activated potassium channel subunit beta-4 (KCNMB4) OTYQG46B KCMB4_HUMAN Decreases Expression [133]
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) OT8L843R EFC4A_HUMAN Increases Expression [133]
Tumor protein p53-inducible protein 13 (TP53I13) OTSUH9V8 P5I13_HUMAN Increases Expression [133]
Basal body-orientation factor 1 (BBOF1) OT88DXU7 BBOF1_HUMAN Increases Expression [133]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Expression [133]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [133]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Increases Expression [133]
Sec1 family domain-containing protein 2 (SCFD2) OTYM55ET SCFD2_HUMAN Increases Expression [133]
Calcyphosin-like protein (CAPSL) OT5RRQ8E CAPSL_HUMAN Increases Expression [133]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Increases Expression [133]
Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) OTYMG99C PGTA_HUMAN Increases Expression [133]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Increases Expression [133]
Ribonuclease K6 (RNASE6) OTJIK1RY RNAS6_HUMAN Increases Expression [133]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [133]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [133]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Increases Expression [133]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (ACAP3) OTOE9OYV ACAP3_HUMAN Increases Expression [133]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [133]
Translin-associated protein X (TSNAX) OTZ9SGWB TSNAX_HUMAN Increases Expression [133]
C-C motif chemokine 19 (CCL19) OTQ2UJMH CCL19_HUMAN Increases Expression [133]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Increases Expression [133]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [133]
Glucose-6-phosphatase 3 (G6PC3) OTH7BWNL G6PC3_HUMAN Increases Expression [133]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Increases Expression [133]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Increases Expression [133]
Intraflagellar transport protein 27 homolog (IFT27) OT3NY6O6 IFT27_HUMAN Increases Expression [133]
Cyclin-dependent kinase 19 (CDK19) OTVMM0CP CDK19_HUMAN Increases Expression [133]
E3 ubiquitin-protein ligase RNF26 (RNF26) OTPXA60S RNF26_HUMAN Increases Expression [133]
tRNA dimethylallyltransferase (TRIT1) OTCU9FS5 MOD5_HUMAN Increases Expression [133]
T-lymphocyte surface antigen Ly-9 (LY9) OT1PKGDI LY9_HUMAN Increases Expression [133]
Striatin-4 (STRN4) OTHK2ZN6 STRN4_HUMAN Increases Expression [133]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [133]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Decreases Expression [133]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [133]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [133]
Tropomodulin-4 (TMOD4) OTXLGJ4R TMOD4_HUMAN Increases Expression [133]
SUN domain-containing protein 2 (SUN2) OT2IQJUC SUN2_HUMAN Increases Expression [133]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Increases Expression [133]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [154]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [154]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [154]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Degradation [168]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Phosphorylation [168]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [160]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [160]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [160]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [160]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [160]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [160]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [160]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [160]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Decreases Expression [160]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [160]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [160]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Decreases Expression [160]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [160]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [160]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Increases Expression [160]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Increases Expression [160]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Increases Expression [160]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [160]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Decreases Expression [160]
Bleomycin hydrolase (BLMH) OT2QPWQJ BLMH_HUMAN Decreases Expression [160]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Increases Expression [160]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [160]
Charged multivesicular body protein 1a (CHMP1A) OTVQ5UWX CHM1A_HUMAN Decreases Expression [160]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [134]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Increases Expression [134]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [134]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Decreases Expression [134]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [134]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [134]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [134]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [134]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [134]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Decreases Expression [134]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Decreases Expression [134]
Pulmonary surfactant-associated protein D (SFTPD) OTNKPDJC SFTPD_HUMAN Increases Expression [134]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [134]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [134]
RNA-binding protein FXR2 (FXR2) OTQX7ATF FXR2_HUMAN Decreases Expression [134]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [134]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [134]
Hemoglobin subunit gamma-2 (HBG2) OT4J48JJ HBG2_HUMAN Increases Expression [134]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Decreases Expression [134]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [134]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Increases Expression [134]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [134]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) OTX2UA7P IQGA2_HUMAN Increases Expression [134]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [134]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Increases Expression [134]
Centromere protein S (CENPS) OTZ4J391 CENPS_HUMAN Increases Expression [134]
LIM domain only protein 7 (LMO7) OTDLY6TC LMO7_HUMAN Increases Expression [134]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Decreases Expression [134]
N-alpha-acetyltransferase 38, NatC auxiliary subunit (NAA38) OTI8VWK3 LSMD1_HUMAN Increases Expression [134]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [134]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Increases Expression [134]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Decreases Expression [134]
Pseudouridylate synthase 1 homolog (PUS1) OTS2DQ0N PUS1_HUMAN Increases Expression [134]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [135]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Increases Expression [135]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [135]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [135]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [135]
Tumor protein D54 (TPD52L2) OTTOG0NK TPD54_HUMAN Decreases Expression [135]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [135]
GDNF family receptor alpha-3 (GFRA3) OT07XAZF GFRA3_HUMAN Increases Expression [135]
Tetraspanin-3 (TSPAN3) OT7WS6ZI TSN3_HUMAN Decreases Expression [135]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Decreases Expression [135]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Increases Expression [135]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [135]
Gamma-aminobutyric acid receptor-associated protein (GABARAP) OTAQUX6E GBRAP_HUMAN Decreases Expression [135]
Histone acetyltransferase KAT7 (KAT7) OTUN98IC KAT7_HUMAN Decreases Expression [135]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Increases Expression [135]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Decreases Expression [135]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [135]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Decreases Expression [135]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Decreases Expression [135]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [135]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Decreases Expression [135]
Argininosuccinate lyase (ASL) OTI2NGQR ARLY_HUMAN Decreases Expression [135]
Calpain small subunit 1 (CAPNS1) OT95EBBD CPNS1_HUMAN Decreases Expression [135]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OTEG4KU9 RPN1_HUMAN Decreases Expression [135]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Expression [135]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [135]
Adenine phosphoribosyltransferase (APRT) OT5ZUKVF APT_HUMAN Decreases Expression [135]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [135]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [135]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Expression [135]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Decreases Expression [135]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Decreases Expression [135]
Furin (FURIN) OTM2665Z FURIN_HUMAN Decreases Expression [135]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [135]
Interferon regulatory factor 1 (IRF1) OT43DI6J IRF1_HUMAN Increases Expression [135]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [135]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Expression [135]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Decreases Expression [135]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [135]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Increases Expression [135]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [135]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Decreases Expression [135]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [135]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Increases Expression [135]
Probable ATP-dependent RNA helicase DDX5 (DDX5) OTLS124U DDX5_HUMAN Increases Expression [135]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [135]
E3 ubiquitin-protein ligase TRIM21 (TRIM21) OTA4UJCF RO52_HUMAN Decreases Expression [135]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Decreases Expression [135]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Increases Expression [135]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [135]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [135]
Granulysin (GNLY) OTZJKA8C GNLY_HUMAN Decreases Expression [135]
Peptidyl-prolyl cis-trans isomerase B (PPIB) OTLPH6KN PPIB_HUMAN Decreases Expression [135]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Decreases Expression [135]
T-cell differentiation antigen CD6 (CD6) OTOS044E CD6_HUMAN Decreases Expression [135]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Decreases Expression [135]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [135]
Cytokine receptor common subunit gamma (IL2RG) OTRZ3OMY IL2RG_HUMAN Decreases Expression [135]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Decreases Expression [135]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Decreases Expression [135]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [135]
Protein DEK (DEK) OTYCJ5H6 DEK_HUMAN Increases Expression [135]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [135]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [135]
Prolyl endopeptidase (PREP) OTSJZBB5 PPCE_HUMAN Decreases Expression [135]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Expression [135]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [135]
Dual specificity protein kinase CLK2 (CLK2) OT1CRSY2 CLK2_HUMAN Decreases Expression [135]
Dual specificity protein kinase CLK3 (CLK3) OT74DJ3J CLK3_HUMAN Decreases Expression [135]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [135]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [135]
Hepatoma-derived growth factor (HDGF) OT16PTBC HDGF_HUMAN Decreases Expression [135]
F-actin-capping protein subunit alpha-1 (CAPZA1) OTAXA66U CAZA1_HUMAN Increases Expression [135]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [135]
Protein SEC13 homolog (SEC13) OTSR4WWM SEC13_HUMAN Decreases Expression [135]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [135]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Expression [135]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Expression [135]
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) OT4B0TNV PP4C_HUMAN Decreases Expression [135]
V-type proton ATPase subunit d 1 (ATP6V0D1) OT9GU2NW VA0D1_HUMAN Decreases Expression [135]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [135]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [135]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [135]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Increases Expression [135]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [135]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [135]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Increases Expression [135]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Decreases Expression [135]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [135]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) OTQ2959Y KLRB1_HUMAN Increases Expression [135]
Protein flightless-1 homolog (FLII) OT7G9JG6 FLII_HUMAN Decreases Expression [135]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [135]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Decreases Expression [135]
Peptidyl-prolyl cis-trans isomerase G (PPIG) OTZ8BTTM PPIG_HUMAN Increases Expression [135]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [135]
Flotillin-2 (FLOT2) OTZ0QR5L FLOT2_HUMAN Decreases Expression [135]
Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) OT2YERNV PTCA_HUMAN Decreases Expression [135]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [135]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [135]
Myeloid leukemia factor 2 (MLF2) OTU3B4WU MLF2_HUMAN Decreases Expression [135]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Decreases Expression [135]
Proprotein convertase subtilisin/kexin type 7 (PCSK7) OTVR1K2Y PCSK7_HUMAN Decreases Expression [135]
Protein NKG7 (NKG7) OTXDD006 NKG7_HUMAN Decreases Expression [135]
MAP kinase-activated protein kinase 3 (MAPKAPK3) OT7IWJNI MAPK3_HUMAN Decreases Expression [135]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Decreases Expression [135]
All-trans retinoic acid-induced differentiation factor (ATRAID) OTOHZG1O ARAID_HUMAN Decreases Expression [135]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Increases Expression [135]
F-box only protein 11 (FBXO11) OTGWF3Q2 FBX11_HUMAN Increases Expression [135]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Decreases Expression [135]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Increases Expression [135]
Pumilio homolog 2 (PUM2) OT2H7NXV PUM2_HUMAN Increases Expression [135]
PEST proteolytic signal-containing nuclear protein (PCNP) OTJUQ122 PCNP_HUMAN Increases Expression [135]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [135]
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) OTS8G0EN BAP1_HUMAN Decreases Expression [135]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [135]
Protein TFG (TFG) OT2KJENI TFG_HUMAN Increases Expression [135]
Ninjurin-1 (NINJ1) OTLRZ1EU NINJ1_HUMAN Decreases Expression [135]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Expression [135]
Granulocyte colony-stimulating factor receptor (CSF3R) OTXRAY6X CSF3R_HUMAN Decreases Expression [135]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Decreases Expression [135]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Decreases Expression [135]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [135]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Decreases Expression [135]
Programmed cell death protein 10 (PDCD10) OTCHJTSF PDC10_HUMAN Increases Expression [135]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Decreases Expression [135]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [135]
Large ribosomal subunit protein mL46 (MRPL46) OTMQ2A0Q RM46_HUMAN Increases Expression [135]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Increases Expression [135]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [135]
Mediator of RNA polymerase II transcription subunit 4 (MED4) OTALFN4S MED4_HUMAN Increases Expression [135]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [135]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [135]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [135]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Decreases Expression [135]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Decreases Expression [135]
Tyrosine-protein kinase BAZ1B (BAZ1B) OTD5KR2J BAZ1B_HUMAN Decreases Expression [135]
F-box/LRR-repeat protein 3 (FBXL3) OTDQ1QKV FBXL3_HUMAN Increases Expression [135]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) OTK81F92 ACINU_HUMAN Decreases Expression [135]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [135]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Increases Expression [169]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [170]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [171]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Expression [172]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [172]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [172]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [173]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [173]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [173]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Activity [174]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [175]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [176]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Increases Expression [176]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [176]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [177]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [178]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [179]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [155]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [155]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [176]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [180]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [181]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Expression [176]
Ornithine transcarbamylase, mitochondrial (OTC) OTJ57GGA OTC_HUMAN Decreases Expression [182]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Cleavage [183]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [184]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Affects Activity [185]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [186]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [176]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Expression [187]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [178]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Secretion [188]
Fibrinogen beta chain (FGB) OT6RKLI9 FIBB_HUMAN Decreases Secretion [188]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Secretion [188]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [176]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [189]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Acetylation [190]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [191]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [139]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [192]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Affects Expression [193]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [194]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [195]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [196]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Secretion [186]
Apolipoprotein(a) (LPA) OTRZLU9F APOA_HUMAN Decreases Expression [197]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Expression [178]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [198]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [199]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [177]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [200]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Activity [201]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [176]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [176]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Affects Methylation [202]
Xaa-Pro dipeptidase (PEPD) OT3LFY7S PEPD_HUMAN Increases Activity [203]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [204]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Decreases Expression [205]
Sucrase-isomaltase, intestinal (SI) OTUP724T SUIS_HUMAN Increases Activity [187]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Decreases Expression [176]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Decreases Expression [206]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Activity [207]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [208]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [209]
P-selectin (SELP) OTWR90PK LYAM3_HUMAN Decreases Expression [210]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Decreases Expression [210]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [176]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Increases Expression [178]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [211]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [136]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [176]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [176]
N-formyl peptide receptor 2 (FPR2) OTEZ2THZ FPR2_HUMAN Increases Expression [212]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Decreases Expression [210]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [176]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [176]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [176]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [213]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [176]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [213]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [210]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [176]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [176]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Increases Expression [155]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Localization [208]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [214]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [175]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [176]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [176]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [139]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [215]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [161]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Activity [216]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [200]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [217]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Increases Expression [218]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [136]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [219]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [215]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [220]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [209]
Dermcidin (DCD) OTV5PBGJ DCD_HUMAN Decreases Secretion [188]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [178]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [221]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Expression [176]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [176]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Expression [176]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [222]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [223]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [224]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Localization [225]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Cleavage [199]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [176]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [226]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [180]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Increases Expression [175]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [219]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [178]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [200]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Expression [200]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [176]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [136]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [176]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [227]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Decreases Expression [181]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [176]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [176]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [180]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [180]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Decreases Expression [220]
Gastrokine-1 (GKN1) OT7ZYFQ9 GKN1_HUMAN Affects Expression [228]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [176]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [178]
Cysteinyl leukotriene receptor 1 (CYSLTR1) OT904HBN CLTR1_HUMAN Increases Expression [229]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Increases Expression [230]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [219]
Interleukin-1 receptor type 2 (IL1R2) OT0G7E35 IL1R2_HUMAN Affects Response To Substance [231]
Prostaglandin E2 receptor EP2 subtype (PTGER2) OT1AUZAA PE2R2_HUMAN Affects Response To Substance [232]
Voltage-dependent calcium channel gamma-6 subunit (CACNG6) OT2PC1E1 CCG6_HUMAN Affects Response To Substance [233]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases ADR [234]
T-box transcription factor TBX21 (TBX21) OT3UK5KE TBX21_HUMAN Affects Response To Substance [235]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Affects Response To Substance [157]
Platelet glycoprotein VI (GP6) OT4IE8DV GPVI_HUMAN Decreases Response To Substance [236]
Platelet glycoprotein Ib alpha chain (GP1BA) OT62PSOB GP1BA_HUMAN Increases Response To Substance [237]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Affects Response To Substance [238]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Affects Response To Substance [231]
Histamine N-methyltransferase (HNMT) OT9F303M HNMT_HUMAN Affects Response To Substance [157]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases ADR [167]
Regulator of G-protein signaling 7-binding protein (RGS7BP) OTAGSWMH R7BP_HUMAN Affects Response To Substance [239]
Thromboxane-A synthase (TBXAS1) OTAXZJJ4 THAS_HUMAN Affects Response To Substance [240]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Affects Response To Substance [241]
Serine/threonine-protein kinase 10 (STK10) OTC33Y2F STK10_HUMAN Affects Response To Substance [242]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Hydrolysis [243]
Prostaglandin D2 receptor 2 (PTGDR2) OTCSMVF1 PD2R2_HUMAN Affects Response To Substance [157]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Affects Response To Substance [244]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Affects Response To Substance [245]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [246]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Metabolism [247]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases ADR [167]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Response To Substance [236]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Affects Response To Substance [248]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Affects Response To Substance [249]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Affects Response To Substance [250]
Leucine-rich melanocyte differentiation-associated protein (LRMDA) OTIPNKTU LRMDA_HUMAN Increases ADR [158]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Response To Substance [251]
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) OTIRUOHF FCERA_HUMAN Affects Response To Substance [157]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Affects Response To Substance [252]
High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) OTMCAS2D FCERB_HUMAN Affects Response To Substance [253]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Affects Response To Substance [141]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases ADR [25]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Decreases Response To Substance [254]
Stromal membrane-associated protein 2 (SMAP2) OTPGVRKO SMAP2_HUMAN Affects Response To Substance [255]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Affects Response To Substance [256]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Increases ADR [25]
Glutamate receptor ionotropic, kainate 2 (GRIK2) OTQ41U3D GRIK2_HUMAN Increases ADR [234]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Increases ADR [257]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Affects Response To Substance [258]
P2Y purinoceptor 1 (P2RY1) OTR2KQ6Q P2RY1_HUMAN Decreases Response To Substance [259]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Response To Substance [157]
Cysteinyl leukotriene receptor 2 (CYSLTR2) OTRNEOZ0 CLTR2_HUMAN Affects Response To Substance [157]
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33) OTRZVI77 ADA33_HUMAN Affects Response To Substance [260]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [261]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Affects Response To Substance [262]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Affects Response To Substance [263]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Affects Response To Substance [250]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [264]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Affects Response To Substance [265]
Prostacyclin receptor (PTGIR) OTWTABYM PI2R_HUMAN Affects Response To Substance [157]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Affects Response To Substance [249]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Affects Response To Substance [266]
Galectin-10 (CLC) OTYMYR85 LEG10_HUMAN Affects Response To Substance [267]
Centrosomal protein of 68 kDa (CEP68) OTZDM4J1 CEP68_HUMAN Affects Response To Substance [268]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Increases ADR [269]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Affects Response To Substance [270]
------------------------------------------------------------------------------------
⏷ Show the Full List of 513 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Covid-19 DCFJ0RA N. A. Phase 3 [271]
Hypertriglyceridemia DCN066Z N. A. Phase 1 [272]
------------------------------------------------------------------------------------

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89 Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. J Physiol Pharmacol. 2007 Aug;58 Suppl 3:141-8.
90 Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. Oncol Rep. 2011 Jan;25(1):41-7.
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94 Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun. 2000 May 19;271(3):688-92. doi: 10.1006/bbrc.2000.2697.
95 Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia. Transplant Proc. 2006 Nov;38(9):2899-904. doi: 10.1016/j.transproceed.2006.08.136.
96 Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. Transplantation. 2000 May 15;69(9):1830-6. doi: 10.1097/00007890-200005150-00017.
97 Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
98 Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance. Clin Exp Immunol. 2010 Aug;161(2):298-305. doi: 10.1111/j.1365-2249.2010.04170.x. Epub 2010 May 18.
99 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
100 Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: evidence of different vascular protection by different lipid-lowering treatments. J Clin Endocrinol Metab. 2003 Nov;88(11):5341-7. doi: 10.1210/jc.2003-030724.
101 Simvastatin reduces OX40 and OX40 ligand expression in human peripheral blood mononuclear cells and in patients with atherosclerotic cerebral infarction. J Int Med Res. 2009 May-Jun;37(3):601-10. doi: 10.1177/147323000903700302.
102 Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2083-9. doi: 10.1161/01.ATV.0000096207.01487.36. Epub 2003 Sep 18.
103 Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
104 Temporal gene expression analysis of human coronary artery endothelial cells treated with Simvastatin. Gene Expr. 2008;14(4):229-39. doi: 10.3727/105221608786883834.
105 Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin. J Cardiovasc Pharmacol. 2007 May;49(5):299-305. doi: 10.1097/FJC.0b013e31803d35ce.
106 Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission. Psychiatry Res. 2005 Feb 28;133(2-3):197-203. doi: 10.1016/j.psychres.2004.11.005.
107 Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. Thromb Res. 2008;122(2):191-202. doi: 10.1016/j.thromres.2007.09.017. Epub 2007 Nov 26.
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109 Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
110 HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation. 2005 Mar 22;111(11):1439-47. doi: 10.1161/01.CIR.0000158484.18024.1F.
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116 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
117 Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
118 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
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123 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
124 Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis. J Immunol. 2011 Sep 15;187(6):3431-7. doi: 10.4049/jimmunol.1100580. Epub 2011 Aug 19.
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126 Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo. J Endod. 2009 Mar;35(3):367-72. doi: 10.1016/j.joen.2008.11.024.
127 A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients. Clin Chim Acta. 2005 Oct;360(1-2):46-51. doi: 10.1016/j.cccn.2005.04.001.
128 Physiogenomic association of statin-related myalgia to serotonin receptors. Muscle Nerve. 2007 Sep;36(3):329-35. doi: 10.1002/mus.20871.
129 Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res Clin Pract. 2003 Dec;62(3):169-75. doi: 10.1016/s0168-8227(03)00163-3.
130 NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. PLoS One. 2011 Apr 4;6(4):e18306. doi: 10.1371/journal.pone.0018306.
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132 Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057.
133 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
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136 Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
137 Aspirin-sensitive rhinitis-associated changes in upper airway innervation. Eur Respir J. 2003 Dec;22(6):986-91. doi: 10.1183/09031936.03.00086002.
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139 Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.
140 Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients. Ann Allergy Asthma Immunol. 2010 Oct;105(4):307-312. doi: 10.1016/j.anai.2010.07.006.
141 Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):538-45.
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