Details of the Drug Combination

General Information of Drug Combination (ID: DCDI8VM)

Drug Combination Name
Simvastatin Fenofibrate
Indication
Disease Entry Status REF
Hyperlipidaemia Phase 1 [1]
Component Drugs Simvastatin   DM30SGU Fenofibrate   DMFKXDY
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Simvastatin
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Approved [2]
Atherosclerosis BD40 Approved [2]
Coronary heart disease BA80.Z Approved [2]
Cystic fibrosis CA25 Approved [2]
Depression 6A70-6A7Z Approved [2]
Hypercholesterolaemia 5C80.0 Approved [3]
Hyperlipidemia 5C80.Z Approved [2]
Hyperlipidemia, familial combined, LPL related N.A. Approved [2]
Hypertriglyceridemia 5C80.1 Approved [2]
Pneumonia CA40 Approved [2]
Primary hypercholesterolemia 5C80.00 Approved [2]
Prostate carcinoma N.A. Approved [2]
Rhinitis FA20 Approved [2]
Type-1/2 diabetes 5A10-5A11 Approved [2]
Stroke 8B20 Investigative [2]
Simvastatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [9]
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Simvastatin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [12]
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Simvastatin Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [13]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [14]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [17]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [14]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [14]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [14]
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⏷ Show the Full List of 8 DME(s)
Simvastatin Interacts with 264 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [18]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [19]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Response To Substance [20]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Response To Substance [21]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [22]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [23]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Response To Substance [24]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Response To Substance [25]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Activity [22]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [26]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [26]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [26]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [27]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Expression [27]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [27]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [27]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Decreases Expression [27]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Expression [6]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [6]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [6]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Decreases Expression [6]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [6]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [6]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [6]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Increases Expression [6]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Expression [6]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [6]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [6]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Decreases Expression [6]
Keratin, type I cytoskeletal 13 (KRT13) OTTYSKGX K1C13_HUMAN Increases Expression [6]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [6]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [6]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Increases Expression [6]
Calmodulin-like protein 3 (CALML3) OTM8DNQU CALL3_HUMAN Increases Expression [6]
Gap junction beta-2 protein (GJB2) OTBKLEYB CXB2_HUMAN Increases Expression [6]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [6]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Increases Expression [6]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [6]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Increases Expression [6]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [6]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [6]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [6]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [6]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [6]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [6]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Increases Expression [6]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Increases Expression [6]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [6]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Activity [6]
Lymphotoxin-beta (LTB) OTUFS8CF TNFC_HUMAN Decreases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [6]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [6]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [6]
Rho GTPase-activating protein 29 (ARHGAP29) OT8JH4TY RHG29_HUMAN Decreases Expression [6]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [6]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [6]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Expression [6]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [6]
Spondin-2 (SPON2) OTE7JLNM SPON2_HUMAN Increases Expression [6]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [6]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [6]
Matrix metalloproteinase-28 (MMP28) OTHQZXM1 MMP28_HUMAN Increases Expression [6]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Decreases Expression [6]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [6]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Increases Expression [6]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Activity [28]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Localization [29]
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) OT6GWW1P NPCL1_HUMAN Decreases Expression [30]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [31]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Expression [31]
Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) OTX31RLZ KI2S2_HUMAN Decreases Expression [31]
Killer cell lectin-like receptor subfamily F member 1 (KLRF1) OTGHZ7FU KLRF1_HUMAN Decreases Expression [31]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Phosphorylation [32]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Nitrosation [32]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Phosphorylation [32]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Increases Expression [33]
Sphingosine 1-phosphate receptor 1 (S1PR1) OTLTXDQT S1PR1_HUMAN Increases Expression [34]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [35]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [36]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Secretion [37]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [38]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [39]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Increases Expression [39]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [40]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [40]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [41]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [42]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [43]
Suppressor of cytokine signaling 7 (SOCS7) OT503VJG SOCS7_HUMAN Increases Expression [44]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [44]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [45]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [46]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [47]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [48]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [43]
Alpha-actinin-4 (ACTN4) OTCNZAJ5 ACTN4_HUMAN Increases Expression [49]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Degradation [50]
Nephrin (NPHS1) OT21JD3P NPHN_HUMAN Increases Expression [49]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [41]
Apolipoprotein M (APOM) OTI3FQQC APOM_HUMAN Decreases Expression [51]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [52]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [53]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [54]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [55]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [56]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Prenylation [57]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Decreases Activity [58]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [59]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Activity [60]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Expression [44]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [44]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [61]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [62]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [63]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Expression [64]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [65]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Increases Expression [66]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Affects Expression [41]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [67]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Secretion [68]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Activity [69]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [70]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [71]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [72]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Activity [73]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [74]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Increases Expression [44]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [75]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Affects Expression [76]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [77]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [78]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [74]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Localization [79]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [80]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Increases Expression [53]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [81]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [82]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [83]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Increases Expression [53]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Activity [84]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [85]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [86]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [43]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [77]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [87]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [88]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Affects Expression [89]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [81]
Cholesteryl ester transfer protein (CETP) OTAGPPOE CETP_HUMAN Decreases Expression [90]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [91]
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Increases Expression [92]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [77]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [93]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [94]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Affects Expression [61]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Activity [95]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Increases Expression [96]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Affects Localization [43]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [71]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [97]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Increases Expression [53]
Cytotoxic T-lymphocyte protein 4 (CTLA4) OTYQR611 CTLA4_HUMAN Decreases Expression [44]
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Decreases Expression [98]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Increases Expression [63]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [74]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Expression [96]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Decreases Expression [99]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [44]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [91]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [41]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Decreases Expression [44]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [100]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [69]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [69]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [101]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Affects Expression [102]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Affects Expression [61]
Type-1 angiotensin II receptor (AGTR1) OT2NRMJP AGTR1_HUMAN Decreases Expression [103]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Increases Activity [104]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [105]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [82]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [106]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [56]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Activity [107]
C-C chemokine receptor type 2 (CCR2) OTQ7T10J CCR2_HUMAN Decreases Expression [108]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [41]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [109]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [110]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Expression [99]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Decreases Expression [52]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [111]
CX3C chemokine receptor 1 (CX3CR1) OTIM9XT8 CX3C1_HUMAN Decreases Expression [112]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [113]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Expression [89]
Nuclear receptor ROR-gamma (RORC) OTUBFRPC RORG_HUMAN Decreases Expression [44]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Decreases Expression [93]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [114]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Activity [115]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) OT2TTZPZ CDN2D_HUMAN Increases Expression [91]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Affects Localization [43]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Increases Expression [53]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Expression [116]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Activity [69]
Rho GTPase-activating protein 4 (ARHGAP4) OTXV053R RHG04_HUMAN Increases Expression [53]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Increases Expression [89]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Affects Localization [82]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Phosphorylation [117]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [41]
Myosin light chain 5 (MYL5) OT7CQ24K MYL5_HUMAN Increases Expression [63]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Decreases Expression [53]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [87]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [48]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [118]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Decreases Localization [115]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [45]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) OTYOORME NFAC3_HUMAN Decreases Localization [119]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Increases Expression [63]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [48]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [43]
Bone morphogenetic protein receptor type-2 (BMPR2) OTM9W547 BMPR2_HUMAN Increases Stability [120]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [85]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Affects Localization [53]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Degradation [50]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [121]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [122]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Decreases Expression [45]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Decreases Expression [44]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [7]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [72]
Interleukin-27 subunit alpha (IL27) OTIS3OF8 IL27A_HUMAN Increases Expression [44]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Increases Expression [123]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Phosphorylation [115]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Increases Expression [53]
Interleukin-17F (IL17F) OT9W9DE0 IL17F_HUMAN Decreases Secretion [122]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Decreases Expression [123]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Expression [45]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [47]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Expression [96]
Interleukin-22 (IL22) OTW31FU9 IL22_HUMAN Decreases Secretion [122]
Interleukin-21 (IL21) OTABCY4W IL21_HUMAN Decreases Expression [44]
Podocin (NPHS2) OTLCNUII PODO_HUMAN Increases Expression [49]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [44]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [43]
Dentin sialophosphoprotein (DSPP) OT1TYNDN DSPP_HUMAN Increases Expression [124]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Affects Expression [76]
CD2-associated protein (CD2AP) OTC76KQM CD2AP_HUMAN Increases Expression [49]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Affects Response To Substance [125]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Increases Response To Substance [126]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [37]
Leptin receptor (LEPR) OT9H7G0C LEPR_HUMAN Affects Response To Substance [127]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases ADR [23]
Small ribosomal subunit protein mS31 (MRPS31) OTB0OBWK RT31_HUMAN Decreases Response To Substance [128]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [128]
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) OTCVXOD6 SCAP_HUMAN Affects Response To Substance [129]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases ADR [130]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Response To Substance [128]
5-hydroxytryptamine receptor 3B (HTR3B) OTMGIYRE 5HT3B_HUMAN Increases Response To Substance [126]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Decreases Response To Substance [128]
------------------------------------------------------------------------------------
⏷ Show the Full List of 264 DOT(s)
Indication(s) of Fenofibrate
Disease Entry ICD 11 Status REF
Coronary atherosclerosis N.A. Approved [4]
High cholesterol level 5C80.0 Approved [5]
Hypercholesterolaemia 5C80.0 Approved [4]
Hyperlipidemia 5C80.Z Approved [4]
Hyperlipidemia, familial combined, LPL related N.A. Approved [4]
Hypertriglyceridemia 5C80.1 Approved [4]
Obesity 5B81 Approved [4]
Fenofibrate Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Peroxisome proliferator-activated receptor alpha (PPARA) TTJ584C PPARA_HUMAN Agonist [135]
------------------------------------------------------------------------------------
Fenofibrate Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [136]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [137]
------------------------------------------------------------------------------------
Fenofibrate Interacts with 240 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [138]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [138]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [139]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [139]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [139]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Increases Expression [29]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Decreases Activity [140]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Increases Expression [141]
Cytochrome P450 3A7 (CYP3A7) OTTCDHHM CP3A7_HUMAN Increases Expression [141]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Activity [142]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [36]
Isocitrate dehydrogenase subunit beta, mitochondrial (IDH3B) OTR89YF5 IDH3B_HUMAN Increases Expression [132]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [132]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Increases Expression [132]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Increases Expression [132]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) OTVKRET0 THIK_HUMAN Increases Expression [132]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [132]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Increases Expression [132]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Increases Expression [132]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Increases Expression [132]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [132]
Phosphoglucomutase-1 (PGM1) OT3VM4JX PGM1_HUMAN Increases Expression [132]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) OT50L4XB ACADV_HUMAN Increases Expression [132]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1) OTDCSPXH SUCA_HUMAN Increases Expression [132]
Trifunctional enzyme subunit beta, mitochondrial (HADHB) OT4Y1I62 ECHB_HUMAN Increases Expression [132]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [132]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [132]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Increases Expression [132]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Increases Expression [132]
Long-chain fatty acid transport protein 4 (SLC27A4) OTWT4HAF S27A4_HUMAN Increases Expression [132]
Aconitate hydratase, mitochondrial (ACO2) OTF2UVNV ACON_HUMAN Increases Expression [132]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [133]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Expression [133]
Krueppel-like factor 11 (KLF11) OTKVQDJD KLF11_HUMAN Increases Expression [133]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [133]
Transcription intermediary factor 1-alpha (TRIM24) OTA45FTS TIF1A_HUMAN Increases Expression [133]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [133]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [133]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Decreases Expression [133]
Aquaporin-9 (AQP9) OTLGH5ZY AQP9_HUMAN Decreases Expression [133]
LYR motif-containing protein 1 (LYRM1) OTV3AJDJ LYRM1_HUMAN Increases Expression [133]
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) OT6CLFXB MCAT_HUMAN Increases Expression [133]
Perilipin-1 (PLIN1) OT3OAAZ4 PLIN1_HUMAN Increases Expression [133]
Peroxisomal membrane protein 11A (PEX11A) OT8MJ9CJ PX11A_HUMAN Increases Expression [133]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Increases Expression [133]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) OT6WZPWV KBL_HUMAN Decreases Expression [133]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Decreases Expression [133]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Decreases Expression [133]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Increases Expression [133]
Galactose-1-phosphate uridylyltransferase (GALT) OTCATU66 GALT_HUMAN Increases Expression [133]
All-trans-retinol dehydrogenase ADH4 (ADH4) OTKDKKNG ADH4_HUMAN Decreases Expression [133]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Increases Expression [133]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Increases Expression [133]
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) OTXX61VZ ETFA_HUMAN Increases Expression [133]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Expression [133]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [133]
Fumarylacetoacetase (FAH) OTGZA1YR FAAA_HUMAN Increases Expression [133]
Arylacetamide deacetylase (AADAC) OT8VACT2 AAAD_HUMAN Increases Expression [133]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [133]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Increases Expression [133]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Increases Expression [133]
Pyruvate kinase PKLR (PKLR) OTTTM1QI KPYR_HUMAN Decreases Expression [133]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Increases Expression [133]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Expression [133]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [133]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [133]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [133]
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) OTGLVWOP THIM_HUMAN Increases Expression [133]
Tryptophan 2,3-dioxygenase (TDO2) OTV5HKJ4 T23O_HUMAN Increases Expression [133]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [133]
Peroxisomal multifunctional enzyme type 2 (HSD17B4) OT8733D7 DHB4_HUMAN Increases Expression [133]
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) OTC3RUN9 HMCS2_HUMAN Increases Expression [133]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Expression [133]
Tyrosine-protein kinase Mer (MERTK) OTWBRAJ6 MERTK_HUMAN Increases Expression [133]
Krueppel-like factor 10 (KLF10) OT4F4UGS KLF10_HUMAN Increases Expression [133]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Decreases Expression [133]
Glycine N-methyltransferase (GNMT) OT0O2OQO GNMT_HUMAN Decreases Expression [133]
Metabotropic glutamate receptor 3 (GRM3) OTJFGE9S GRM3_HUMAN Increases Expression [133]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Decreases Expression [133]
Monocyte to macrophage differentiation factor (MMD) OTB5I4OC PAQRB_HUMAN Increases Expression [133]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Increases Expression [133]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Decreases Expression [133]
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) OTOSKSFH ETFD_HUMAN Increases Expression [133]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [133]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [133]
Phospholipase A1 member A (PLA1A) OT2IXYNX PLA1A_HUMAN Increases Expression [133]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [133]
NEDD4-binding protein 2-like 1 (N4BP2L1) OTEGV3GO N42L1_HUMAN Increases Expression [133]
Cytochrome P450 4A22 (CYP4A22) OTHO7KC4 CP4AM_HUMAN Increases Expression [133]
Protein FAM222A (FAM222A) OTRD9AUH F222A_HUMAN Increases Expression [133]
PI-PLC X domain-containing protein 3 (PLCXD3) OTJNSWMU PLCX3_HUMAN Decreases Expression [133]
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) OTDMU3GP CR3L3_HUMAN Increases Expression [133]
Lysophospholipid acyltransferase 5 (LPCAT3) OTWI96P4 MBOA5_HUMAN Increases Expression [133]
Solute carrier family 25 member 34 (SLC25A34) OTY1YFLG S2534_HUMAN Increases Expression [133]
Leucine-rich repeat-containing protein 31 (LRRC31) OT7VCU13 LRC31_HUMAN Increases Expression [133]
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) OT6NTBAA PCAT2_HUMAN Increases Expression [133]
Monocarboxylate transporter 13 (SLC16A13) OTAJ5CPB MOT13_HUMAN Increases Expression [133]
Target of Nesh-SH3 (ABI3BP) OTW8DN50 TARSH_HUMAN Decreases Expression [133]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [133]
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) OT7XETW4 HOGA1_HUMAN Decreases Expression [133]
Sphingosine-1-phosphate transporter SPNS2 (SPNS2) OTPODAPU SPNS2_HUMAN Increases Expression [133]
Cyclin-dependent kinase 20 (CDK20) OTOLNN68 CDK20_HUMAN Increases Expression [133]
Cytochrome P450 4X1 (CYP4X1) OTMTEUNE CP4X1_HUMAN Increases Expression [133]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Increases Expression [133]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Decreases Expression [133]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [133]
Thyroid hormone-inducible hepatic protein (THRSP) OTKYE01L THRSP_HUMAN Decreases Expression [133]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Increases Expression [133]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [133]
Membrane-spanning 4-domains subfamily A member 10 (MS4A10) OTH3LAUX M4A10_HUMAN Decreases Expression [133]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [133]
C-C motif chemokine 13 (CCL13) OTNX0JD0 CCL13_HUMAN Increases Expression [133]
Ion channel TACAN (TMEM120A) OTBS3YWY TACAN_HUMAN Decreases Expression [133]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [133]
Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2) OTO6QUTM AGT2_HUMAN Decreases Expression [133]
cAMP-dependent protein kinase inhibitor beta (PKIB) OT7C8GFN IPKB_HUMAN Increases Expression [133]
Potassium channel subfamily K member 13 (KCNK13) OTMOT2KX KCNKD_HUMAN Increases Expression [133]
Serine/threonine-protein kinase Sgk2 (SGK2) OTCTVSHF SGK2_HUMAN Increases Expression [133]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Decreases Expression [133]
Protein C19orf12 (C19ORF12) OTVSJ1AR CS012_HUMAN Increases Expression [133]
Ethanolamine kinase 2 (ETNK2) OT5S1Z75 EKI2_HUMAN Decreases Expression [133]
Phosphatidylethanolamine N-methyltransferase (PEMT) OTKXRUL9 PEMT_HUMAN Increases Expression [133]
SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2) OTOX4XT7 SH3L2_HUMAN Increases Expression [133]
Excitatory amino acid transporter 5 (SLC1A7) OTVN5C6W EAA5_HUMAN Increases Expression [134]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Decreases Expression [134]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Decreases Expression [134]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [134]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Increases Expression [134]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [134]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Increases Expression [134]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Decreases Expression [134]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [134]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [134]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [134]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [134]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [134]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [134]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Increases Expression [134]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [134]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [134]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [134]
RNA-binding protein RO60 (RO60) OTLGM5A8 RO60_HUMAN Decreases Expression [134]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Expression [134]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [134]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [134]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Affects Activity [134]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [134]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Decreases Expression [134]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [134]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [134]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Increases Expression [134]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [134]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [134]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [134]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Affects Activity [134]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Increases Expression [134]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [134]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [134]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Increases Expression [134]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [134]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Increases Expression [134]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) OTYHXLWZ BCAT1_HUMAN Decreases Expression [134]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [134]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [134]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [134]
Adenylate cyclase type 1 (ADCY1) OTSLLFZO ADCY1_HUMAN Decreases Expression [134]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Decreases Expression [134]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [134]
Probable E3 ubiquitin-protein ligase HERC3 (HERC3) OTWMKYD9 HERC3_HUMAN Increases Expression [134]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Affects Activity [134]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Decreases Expression [134]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Decreases Expression [134]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Affects Activity [134]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [134]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [134]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Decreases Expression [134]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Decreases Expression [134]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Increases Expression [134]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [134]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [134]
KICSTOR complex protein ITFG2 (ITFG2) OT0NLZ8I ITFG2_HUMAN Increases Expression [134]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Decreases Expression [134]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [134]
Spermatid perinuclear RNA-binding protein (STRBP) OTU7XLZL STRBP_HUMAN Increases Expression [134]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [134]
Protein orai-3 (ORAI3) OTUP3OH3 ORAI3_HUMAN Decreases Expression [134]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [134]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [134]
Ankyrin repeat family A protein 2 (ANKRA2) OTLSLV5A ANRA2_HUMAN Increases Expression [134]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Increases Expression [134]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7) OT3QER33 ENTP7_HUMAN Decreases Expression [134]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Decreases Expression [134]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Increases Expression [134]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) OTM3CQZT BIG2_HUMAN Increases Expression [134]
Bifunctional epoxide hydrolase 2 (EPHX2) OTPTRCNW HYES_HUMAN Affects Expression [143]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Affects Expression [143]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [144]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [145]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Decreases Expression [146]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [147]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [148]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [72]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [147]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Decreases Expression [147]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [149]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [150]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [147]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Increases Expression [151]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Expression [151]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Affects Localization [147]
Cytochrome P450 7A1 (CYP7A1) OT8Z5KLD CP7A1_HUMAN Decreases Expression [152]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [145]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [147]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [153]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [144]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [150]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [150]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [154]
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) OTW00PRY AAKG1_HUMAN Increases Expression [147]
Oxysterols receptor LXR-beta (NR1H2) OT4APA60 NR1H2_HUMAN Increases Expression [144]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [155]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [144]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [145]
Platelet-activating factor acetylhydrolase (PLA2G7) OT6H6AMO PAFA_HUMAN Decreases Activity [156]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [144]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [145]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Increases Expression [157]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [153]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [145]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [72]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Increases Expression [148]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Increases Expression [158]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Increases Expression [159]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [160]
Semaphorin-6B (SEMA6B) OT3VVVUO SEM6B_HUMAN Decreases Expression [161]
Fibroblast growth factor 21 (FGF21) OT3RXVRD FGF21_HUMAN Increases Expression [162]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) OT1OG4QZ AAKB1_HUMAN Increases Phosphorylation [147]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Decreases Response To Substance [147]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Affects Response To Substance [163]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Affects Response To Substance [164]
------------------------------------------------------------------------------------
⏷ Show the Full List of 240 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Dyslipidemia DC0JWR7 N. A. Phase 1 [165]
------------------------------------------------------------------------------------

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2 Simvastatin FDA Label
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4 Fenofibrate FDA Label
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