Details of the Drug Combinations

General Information of This Drug (ID: DM5SXUV)

Drug Name
Repaglinide   DM5SXUV
Synonyms
Actulin; GlucoNorm; NovoNorm; Prandin; Repaglinida; Repaglinidum; Glaxo Wellcome brand of replaginide; Novo Nordisk brand of repaglinide; Repaglinide [USAN]; Novo Nordisk brand 2 of repaglinide; AG-EE 388; AG-EE 388 ZW; AG-EE 623 ZW; AGEE-623ZW; GlucoNorm (TN); NN-623; NovoNorm (TN); Prandin (TN); Repa-glinide; Repaglinida [INN-Spanish]; Repaglinidum [INN-Latin]; SMP-508; AG-EE-388; AG-EE-623 ZW; Prandin, GlucoNorm, NovoNorm, Repaglinide; Repaglinide (JAN/USP/INN); Repaglinide, (+-)-isomer; (+)-2-Ethoxy-alpha-(((S)-alpha-isobutyl-o-piperidinobenzyl)carbamoyl)-p-toluic acid; (S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid; (S)-2-Ethoxy-4-(2-((methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)-2-oxoethyl)-benzoic acid; (S)-2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)-phenyl)butyl)amino)-2-oxoethyl)-benzoic acid; 111GE012; 2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)-2-oxoethyl)benzoic acid; 2-ethoxy-4-(2-{[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino}-2-oxoethyl)benzoic acid; 2-ethoxy-4-[2-({(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl}amino)-2-oxoethyl]benzoic acid; 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid; 2-ethoxy-N-(alpha-(2-methyl-1-propyl)-2-piperidinobenzyl)-4-carbamoylmethylbenzoic acid
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Therapeutic Class
Hypoglycemic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

51 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohydroxamic Acid + Repaglinide DC2FK2S Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Repaglinide DCWM2FI Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Repaglinide DCH1166 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Repaglinide DC4J2HO Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Repaglinide DCSMB0Y Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Repaglinide DCPIADL Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + Repaglinide DCPN671 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Repaglinide DCDOPRR Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Repaglinide DC1NQXU Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Repaglinide DCWV2RS Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Idarubicin + Repaglinide DCJVMU8 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Isoproterenol + Repaglinide DCF950S Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Repaglinide DCQ2992 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Repaglinide DCQENSX Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Repaglinide DCOG1OK Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Repaglinide DCPMQW5 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Repaglinide DC99PYT Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Paromomycin + Repaglinide DC9KHHP Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Repaglinide DCEGS4V Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Ribavirin-TP DCU4AQ4 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Anamorelin DC0YF6R Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Isosorbide dinitrate DCZ3YQL Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Emetine DCMUW71 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Docetaxel DCHK4Y6 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Pazopanib DCT4ETA Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Dichlorphenamide DCRWI3V Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Trifluoperazine DC1PBKF Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Diazoxide DCJD50I Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Idarubicin DC20FP1 Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Repaglinide + Darunavir DCU8J0W Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Dopamine DCZ2H63 Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Trimethobenzamide DC0TEAH Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Maprotiline DCAY5VC Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Leflunomide DCX4XGF Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Chlorambucil DC2LPW5 Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Acarbose DCV9Y5A Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Hyodeoxycholic acid DCY5EOI Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Quinine DCRJFRP Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Mycophenolic acid DCCN3WZ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Doxorubicin DCODYR9 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Auranofin DC3BUS8 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Estramustine DCEY702 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Cerivastatin DCEFHQV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Hydroxychloroquine DCYFGRK Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Albendazole DCONIBX Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + L-165041 DCA2IMT L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Silver sulfadiazine + Repaglinide DC6MWYR Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Repaglinide DCOSUO4 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triiodothyronine + Repaglinide DCD0BG4 Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Repaglinide DC1DC5D Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Zaleplon + Repaglinide DCEC8OD Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 51 DrugCom(s)
4 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Repaglinide + Rosiglitazone DCSQ37Q Rosiglitazone Diabetes Mellitus, Type 2 [3]
Repaglinide + Caffeine DC71KZN Caffeine Pharmacokinetics of Repaglinide [4]
Tolbutamide + Repaglinide DCGB03N Tolbutamide Drug-drug Interaction [5]
Repaglinide + Metformin DC04BGN Metformin Type 2 Diabetes Mellitus [6]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6841).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT02475499) Incretin-based Drugs and Pancreatic Cancer
4 ClinicalTrials.gov (NCT02128321) A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine
5 ClinicalTrials.gov (NCT03723395) A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
6 ClinicalTrials.gov (NCT01709305) A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313)