Details of the Drug Combinations

General Information of This Drug (ID: DM7ICNU)

Drug Name
Doxycycline   DM7ICNU
Synonyms
Atridox; Azudoxat; DOXY; Deoxymykoin; Dossiciclina; Doxiciclina; Doxitard; Doxivetin; Doxycen; Doxychel; Doxycin; Doxycyclin; Doxycyclinum; Doxysol; Doxytec; Doxytetracycline; Hydramycin; Investin; Jenacyclin; Liviatin; Monodox; Oracea; Ronaxan; Spanor; Supracyclin; Vibramycin; Vibramycine; Vibravenos; DOXCYCLINE ANHYDROUS; DOXYCYCLINE CALCIUM; DOXYCYCLINE MONOHYDRATE; Dossiciclina [DCIT]; Doxiciclina [Italian]; Doxycycline anhydrous; Doxycycline hyclate; Vibramycin Novum; Alpha-Doxycycline; Alti-Doxycycline; Apo-Doxy; BMY-28689; BU-3839T; Doxiciclina [INN-Spanish]; Doxy-Caps; Doxy-Puren; Doxy-Tabs; Doxychel (TN); Doxycycline (INN); Doxycycline (TN); Doxycycline (anhydrous); Doxycycline (internal use); Doxycycline-Chinoin; Doxycyclinum [INN-Latin]; Novo-Doxylin; Nu-Doxycycline; Periostat (TN); Vibra-tabs; Alpha-6-Deoxyoxytetracycline; DMSC (*Fosfatex); Doxycycline (200mg/day) or Placebo; Monodox (*monohydrate); Vibramycin (*monohydrate); Vivox (*Hyclate); GS-3065 (*monohydrate); Alpha-6-Deoxy-5-hydroxytetracycline; (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS); 5-Hydroxy-alpha-6-deoxytetracycline; 6-Deoxyoxytetracycline; 6-Deoxytetracycline; 6-alpha-Deoxy-5-oxytetracycline; 6alpha-Deoxy-5-oxytetracycline
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Actinomycosis N.A. Approved [1]
Acute gonococcal cervicitis N.A. Approved [1]
Acute gonococcal epididymo-orchitis N.A. Approved [1]
Advanced gum disease DA0D Approved [2]
Anthrax 1B97 Approved [1]
Bartonellosis N.A. Approved [1]
Boutonneuse fever N.A. Approved [1]
Brill-Zinsser disease N.A. Approved [1]
Bronchitis CA20 Approved [1]
Brucellosis N.A. Approved [1]
Chancroid N.A. Approved [1]
Chlamydiaceae infections N.A. Approved [1]
Chronic periodontitis DA0C.Y Approved [2]
Colorectal carcinoma N.A. Approved [1]
Cutaneous anthrax N.A. Approved [1]
Endemic typhus N.A. Approved [1]
Epidemic louse-borne typhus N.A. Approved [1]
Gastrointestinal anthrax N.A. Approved [1]
Inhalational anthrax N.A. Approved [1]
Listeriosis N.A. Approved [1]
Lymphogranuloma venereum N.A. Approved [1]
Mycoplasma pneumoniae pneumonia N.A. Approved [1]
Ornithosis N.A. Approved [1]
Q fever N.A. Approved [1]
Relapsing fever N.A. Approved [1]
Rickettsialpox N.A. Approved [1]
Rickettsiosis N.A. Approved [1]
Rocky mountain spotted fever N.A. Approved [1]
Syphilis N.A. Approved [1]
Trachoma N.A. Approved [1]
Tularemia 1B94 Approved [1]
Typhus N.A. Approved [1]
Yaws N.A. Approved [1]
Diabetic foot ulcer BD54 Phase 2 [3]
Sinusitis CA0A.Z Investigative [1]
Vibrio cholerae infection 1A00 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Atovaquone + Doxycycline DC24339 Atovaquone Hepatoblastoma (Cell Line: HB3) [4]
Doxycycline + Panobinostat DCTL97Q Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [4]
Doxycycline + Piperaquine DC12XST Piperaquine DD2 (Cell Line: DD2) [4]
Doxycycline + Mefloquine DC60EYZ Mefloquine DD2 (Cell Line: DD2) [4]
Doxycycline + Artemisinin DC985EY Artemisinin Hepatoblastoma (Cell Line: HB3) [5]
Eltanexor oral + Doxycycline DCWVW5C Eltanexor oral DD2 (Cell Line: DD2) [4]
GSK2126458 + Doxycycline DCGSU4W GSK2126458 Hepatoblastoma (Cell Line: HB3) [5]
Nitisinone + Doxycycline DCWFY47 Nitisinone Hepatoblastoma (Cell Line: HB3) [4]
Sapanisertib + Doxycycline DC0VCTF Sapanisertib Hepatoblastoma (Cell Line: HB3) [5]
ZSTK474 + Doxycycline DCNON88 ZSTK474 Hepatoblastoma (Cell Line: HB3) [4]
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⏷ Show the Full List of 10 DrugCom(s)
33 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Ciprofloxacin XR + Doxycycline DCA3SJX Ciprofloxacin XR Diabetic Foot Ulcers [6]
Ciprofloxacin XR + Doxycycline DCKLMVK Ciprofloxacin XR Rhinoscleroma [7]
Doxycycline + Cefazolin DC2GG7Y Cefazolin Osteoarthritis [8]
Doxycycline + Erlotinib DC2X23P Erlotinib Non-Small Cell Lung Cancer [9]
Doxycycline + Azelaic Acid DC315AB Azelaic Acid Papulopustular Rosacea [10]
Doxycycline + Minocycline DC5Z0HE Minocycline Aneurysms [11]
Doxycycline + Lymecycline DCA1IUH Lymecycline Urethritis [12]
Doxycycline + Adapalene DCE73Q4 Adapalene Acne Vulgaris [13]
Doxycycline + Dacomitinib DCH6V8Z Dacomitinib Non Small Cell Lung Cancer (NSCLC) [14]
Doxycycline + Amoxicillin DCHVXBY Amoxicillin Periodontitis [15]
Doxycycline + Metronidazole DCJ7WVH Metronidazole Papulopustular Rosacea [10]
Doxycycline + Lefamulin DCEC8EQ Lefamulin Mycoplasma Genitalium Infection [16]
Esomeprazole + Doxycycline DCTCCRU Esomeprazole GASTRITIS [17]
Imiquimod + Doxycycline DCLU9ZB Imiquimod Lymphoma, T-Cell, Cutaneous [18]
Rifampicin + Doxycycline DCFPB9U Rifampicin Alzheimer's Disease [19]
Tindamax + Doxycycline DCKI84K Tindamax Urethritis [20]
Ciprofloxacin XR + Doxycycline DCTTCKY Ciprofloxacin XR Crohn's Disease [21]
Doxycycline + Terbinafine DCBP0V8 Terbinafine Ulcerative Colitis [22]
Doxycycline + Ceftriaxone DCKWPHW Ceftriaxone Pelvic Inflammatory Disease [23]
Doxycycline + Ursodeoxycholic acid DCWFJV6 Ursodeoxycholic acid Transthyretin Amyloidosis [24]
Irbesartan + Doxycycline DCLCV3K Irbesartan Marfan Syndrome [25]
Nitazoxanide + Doxycycline DC4CA4D Nitazoxanide Sexually Transmitted Diseases [26]
Doxycycline + Azithromycin DCEB9X3 Azithromycin COVID 19 [27]
Doxycycline + Prednisolone DCECM0C Prednisolone Nasal Polyps [28]
Diethylcarbamazine + Doxycycline DC5NNNJ Diethylcarbamazine Filarial; Infestation [29]
Doxycycline + Rabeprazole DC5VI5Z Rabeprazole Helicobacter Pylori Infection [30]
Doxycycline + Cephalexin DC8MZW4 Cephalexin Infections Joint Prosthetic [31]
Doxycycline + Zinc Sulfate DC8NTS1 Zinc Sulfate COVID-19 [32]
Doxycycline + Benzylpenicillin DC3SWUO Benzylpenicillin Early Syphilis [33]
Doxycycline + Cefixime DCPHVQR Cefixime Gonorrhea [34]
Doxycycline + Rivaroxaban DCT8K3K Rivaroxaban COVID-19 [35]
Doxycycline + Ivermectin DCUPYZZ Ivermectin Covid19 [36]
Doxycycline + Ceftriaxone DCY6CED Ceftriaxone Early Syphilis [33]
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⏷ Show the Full List of 33 DrugCom(s)

References

1 Doxycycline FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6464).
3 ClinicalTrials.gov (NCT00764361) Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers. U.S. National Institutes of Health.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6 ClinicalTrials.gov (NCT02036528) Safety and Efficacy of Gentamicin Topical Gel (AppliGel-G) for Treatment of Mild to Moderately Infected Diabetic Foot Ulcers
7 ClinicalTrials.gov (NCT05431673) Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma
8 ClinicalTrials.gov (NCT03115177) Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
9 ClinicalTrials.gov (NCT00531934) A Study of Management of Tarceva - Induced Rash in Patients With Non-Small Cell Lung Cancer.
10 ClinicalTrials.gov (NCT00855595) Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea
11 ClinicalTrials.gov (NCT00243893) Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
12 ClinicalTrials.gov (NCT01661985) Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced
13 ClinicalTrials.gov (NCT03585140) Low Glycemic Index and Load Diet for the Treatment of Acne
14 ClinicalTrials.gov (NCT01465802) Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO
15 ClinicalTrials.gov (NCT00066066) Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
16 ClinicalTrials.gov (NCT05111002) Lefamulin for M. Genitalium Treatment Failures
17 ClinicalTrials.gov (NCT02884713) Levofloxacin-Doxycycline for Helicobacter Pylori Eradication in Saudi Arabia
18 ClinicalTrials.gov (NCT03116659) CTCL Directed Therapy
19 ClinicalTrials.gov (NCT00439166) Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid
20 ClinicalTrials.gov (NCT00322465) NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
21 ClinicalTrials.gov (NCT01783106) Antibiotics and Hydroxychloroquine in Crohn's
22 ClinicalTrials.gov (NCT02606032) Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis
23 ClinicalTrials.gov (NCT01160640) The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)
24 ClinicalTrials.gov (NCT02016365) Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis
25 ClinicalTrials.gov (NCT01949233) The Oxford Marfan Trial
26 ClinicalTrials.gov (NCT05897034) Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men
27 ClinicalTrials.gov (NCT04528927) Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia
28 ClinicalTrials.gov (NCT05157412) Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polyps
29 ClinicalTrials.gov (NCT02005653) Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection
30 ClinicalTrials.gov (NCT05061732) Helicobacter Pylori Eradication and Follow-up
31 ClinicalTrials.gov (NCT04297592) Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
32 ClinicalTrials.gov (NCT04370782) Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting
33 ClinicalTrials.gov (NCT05980871) Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline
34 ClinicalTrials.gov (NCT06090565) Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
35 ClinicalTrials.gov (NCT04715295) Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19
36 ClinicalTrials.gov (NCT04729140) An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization