Details of the Drug Combination

General Information of Drug Combination (ID: DCLCV3K)

• Drug Combination Name: Irbesartan + Doxycycline
• Indication: Marfan Syndrome; Status: Phase 2 [1]
• Component Drugs:
  Irbesartan (DMTP1DC): Small molecular drug
  Doxycycline (DM7ICNU): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Irbesartan

Disease Entry	ICD 11	Status	REF
Diabetic kidney disease	GB61.Z	Approved	[2]
Hypertension	BA00-BA04	Approved	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[4]
High blood pressure	BA00	Investigative	[2]

Irbesartan Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Antagonist	[8]
HUMAN type-1 angiotensin II receptor (AGTR1)	TTPKMXQ	AGTR1_HUMAN	Antagonist	[9]

Irbesartan Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[10]

Irbesartan Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[11]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[12]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[13]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Metabolism	[14]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Metabolism	[14]

Irbesartan Interacts with 18 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[12]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[15]
Renin (REN)	OT52GZR2	RENI_HUMAN	Increases Expression	[16]
Carbonic anhydrase 1 (CA1)	OTNFBVVQ	CAH1_HUMAN	Decreases Activity	[17]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Increases Expression	[18]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Increases Expression	[19]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[20]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[20]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Increases Expression	[21]
Type-1 angiotensin II receptor (AGTR1)	OT2NRMJP	AGTR1_HUMAN	Affects Response To Substance	[22]
Endoplasmic reticulum aminopeptidase 1 (ERAP1)	OT72S99B	ERAP1_HUMAN	Affects Response To Substance	[23]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Response To Substance	[24]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Affects Response To Substance	[25]
Cytochrome P450 11B2, mitochondrial (CYP11B2)	OTIOLWYN	C11B2_HUMAN	Increases Response To Substance	[26]
B2 bradykinin receptor (BDKRB2)	OTOA9D3W	BKRB2_HUMAN	Affects Response To Substance	[27]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Affects Response To Substance	[28]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Affects Response To Substance	[29]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Affects Response To Substance	[30]

Indication(s) of Doxycycline

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[5]
Actinomycosis	N.A.	Approved	[5]
Acute gonococcal cervicitis	N.A.	Approved	[5]
Acute gonococcal epididymo-orchitis	N.A.	Approved	[5]
Advanced gum disease	DA0D	Approved	[6]
Anthrax	1B97	Approved	[5]
Bartonellosis	N.A.	Approved	[5]
Boutonneuse fever	N.A.	Approved	[5]
Brill-Zinsser disease	N.A.	Approved	[5]
Bronchitis	CA20	Approved	[5]
Brucellosis	N.A.	Approved	[5]
Chancroid	N.A.	Approved	[5]
Chlamydiaceae infections	N.A.	Approved	[5]
Chronic periodontitis	DA0C.Y	Approved	[6]
Colorectal carcinoma	N.A.	Approved	[5]
Cutaneous anthrax	N.A.	Approved	[5]
Endemic typhus	N.A.	Approved	[5]
Epidemic louse-borne typhus	N.A.	Approved	[5]
Gastrointestinal anthrax	N.A.	Approved	[5]
Inhalational anthrax	N.A.	Approved	[5]
Listeriosis	N.A.	Approved	[5]
Lymphogranuloma venereum	N.A.	Approved	[5]
Mycoplasma pneumoniae pneumonia	N.A.	Approved	[5]
Ornithosis	N.A.	Approved	[5]
Q fever	N.A.	Approved	[5]
Relapsing fever	N.A.	Approved	[5]
Rickettsialpox	N.A.	Approved	[5]
Rickettsiosis	N.A.	Approved	[5]
Rocky mountain spotted fever	N.A.	Approved	[5]
Syphilis	N.A.	Approved	[5]
Trachoma	N.A.	Approved	[5]
Tularemia	1B94	Approved	[5]
Typhus	N.A.	Approved	[5]
Yaws	N.A.	Approved	[5]
Diabetic foot ulcer	BD54	Phase 2	[7]
Sinusitis	CA0A.Z	Investigative	[5]
Vibrio cholerae infection	1A00	Investigative	[5]

Doxycycline Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Modulator	[32]

Doxycycline Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[33]

Doxycycline Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[34]

Doxycycline Interacts with 9 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[35]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[31]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[31]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Affects Expression	[36]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Activity	[37]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Activity	[37]
Neutrophil collagenase (MMP8)	OTZXH19L	MMP8_HUMAN	Decreases Activity	[37]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Increases Expression	[38]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Decreases Expression	[39]

References

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