Details of the Drug Combinations

General Information of This Drug (ID: DMGFWSM)

Drug Name
Zaleplon   DMGFWSM
Synonyms
Sonata; Zalaplon; Zerene; CL 284846; L 846; L846; LJC 10846; ZAL 846; AZ-007; CL 284,846; CL-284846; CL284,846; L-846; LJC-10846; SKP-1041; Sonata (TN); Staccato-zaleplon; Starnoc (TN); ZAL-846; Zaleplon [USAN:INN]; Zaleplon (JAN/USAN/INN); N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide; N-(3-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide; 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide; 3'-(3-Cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide
Indication
Disease Entry ICD 11 Status REF
Insomnia 7A00-7A0Z Approved [1]
Sleep disorder, initiating and maintaining sleep N.A. Investigative [2]
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

47 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Zaleplon DCH2HWV Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Albendazole + Zaleplon DC7ACTF Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BHV-0223 + Zaleplon DC66AAO BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Zaleplon DCG8R9K Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Zaleplon DCLTZX4 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cinacalcet + Zaleplon DCBX7M7 Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxorubicin + Zaleplon DCDELK1 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Lacosamide + Zaleplon DC7HIRM Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Zaleplon DC27SKB Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Zaleplon DCPD5JV Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Zaleplon DCNYD6T Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Zaleplon DCXBO2L Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oseltamivir + Zaleplon DCDG18M Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Procarbazine + Zaleplon DCD32FY Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Zaleplon DCTTEZ2 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
VR-776 + Zaleplon DCGJFJ2 VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Aprepitant DC3CHIK Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Pentostatin DC7COW5 Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Gefitinib DCSLRDK Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Epinephrine DCSPFUO Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Methotrexate DCG4R0Y Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Repaglinide DCEC8OD Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Fomepizole DCHGOI7 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Buspirone DC9587B Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Terameprocol DC3BBUH Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Itraconazole DCHNROA Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Armodafinil DC8Y4Y8 Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Diphenidol DCUL82E Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Eflornithine DCI0AOK Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + GINKGOLIDE A DC2OYYT GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Diazoxide DC98XN4 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Imatinib DCD8YHY Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Bortezomib DC7CU97 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Trimethobenzamide DCECB6O Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Enalaprilat DCMSC5H Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Leflunomide DC7N7C2 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Theophylline DCX1TCQ Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Amantadine DCMLZ5G Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Valproic Acid DCIILCW Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Mycophenolic acid DCB11G6 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Cisatracurium DC4CK7P Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Vorinostat DCUF7L8 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Cerivastatin DCMN6FC Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Hydroxychloroquine DCSEZ6C Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Aciclovir DCNLE0X Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Tetracycline DC8QIF7 Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zaleplon + Cytarabine DCP6ZQO Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 47 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4345).
2 Zaleplon FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.