Details of the Drug Combinations

General Information of This Drug (ID: DMGO72P)

Drug Name

Oseltamivir DMGO72P

Synonyms

Tamiflu (*Phosphate salt 1:1*); Agucort; Oseltamivirum; Tamvir; GS 4104; GS4104; Agucort (TN); GS-4104; Oseltamivir (INN); Oseltamivir [INN:BAN]; Ro-640796; Tamiflu (TN); Tamiflu-Free; Ro-64-0796; OTV

Indication

Disease Entry	ICD 11	Status	REF
Influenza	1E30-1E32	Approved	[1]
Influenza virus infection	1E30-1E32	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
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Therapeutic Class

Antiviral Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

79 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acitretin + Oseltamivir	DC1GBUZ	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Aminosalicylic acid + Oseltamivir	DCYMIIX	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Bortezomib + Oseltamivir	DCTIGFF	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Brincidofovir + Oseltamivir	DCEKG8K	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
BRL-15572 + Oseltamivir	DCW008H	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Bumetanide + Oseltamivir	DCXTQDW	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cerivastatin + Oseltamivir	DC4SM8V	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Citalopram + Oseltamivir	DC9ZUAB	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dantrolene + Oseltamivir	DCKH35H	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dexmedetomidine + Oseltamivir	DCPNAUV	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dichlorphenamide + Oseltamivir	DCN8CKA	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Diethylcarbamazine + Oseltamivir	DCI4Z63	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Diphenidol + Oseltamivir	DCTJXJO	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Docetaxel + Oseltamivir	DCPN0GK	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Estramustine + Oseltamivir	DC5CF9U	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Fibrates + Oseltamivir	DC8LYHB	Fibrates	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Fomepizole + Oseltamivir	DC12RX3	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Gefitinib + Oseltamivir	DC6DH8F	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
GINKGOLIDE A + Oseltamivir	DC4N9C2	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Guanfacine + Oseltamivir	DC31SKZ	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
GYKI-52466 + Oseltamivir	DC4S9K2	GYKI-52466	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
IT-141 + Oseltamivir	DCX0GUO	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Lefaxin + Oseltamivir	DCSLF0Z	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Maprotiline + Oseltamivir	DCNSBX0	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mebutamate + Oseltamivir	DCN7XYV	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mefloquine + Oseltamivir	DC5WC0T	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Methotrexate + Oseltamivir	DCIALHR	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Methylergonovine + Oseltamivir	DCNINON	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mycophenolic acid + Oseltamivir	DCLYIDW	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Norcisapride + Oseltamivir	DCMRC4P	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Aprepitant	DCPJQT0	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Triiodothyronine	DCOII6T	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Triamterene	DCT2SRJ	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Triapine	DCFD5UL	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Everolimus	DCSSRYN	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Testosterone cypionate	DC23WIS	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Terameprocol	DC29EJB	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Carglumic acid	DCNGHA7	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Chlorzoxazone	DC6P4KQ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Methoxsalen	DCWR7NQ	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Sulfinpyrazone	DCOL71V	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Zaleplon	DCDG18M	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Pentamidine	DCKBFSZ	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Arfolitixorin	DCSTO6E	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Isoproterenol	DCWI4OO	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Diazoxide	DCXM32Q	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Atenolol	DCDH9VG	Atenolol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Moricizine	DCVO7UU	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Artemisinin	DCP1W7H	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Topotecan	DCF8F59	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Acarbose	DCXVAW6	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Brincidofovir	DC8B3JP	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Chlormezanone	DCWQ257	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Mycophenolic acid	DCXAO1M	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Hydralazine	DCJB4CG	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Cisatracurium	DCF4JQI	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Silver sulfadiazine	DC48GZB	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Olmesartan medoxomil	DCIAAC1	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Auranofin	DC1IFBW	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + FORMESTANE	DCRG65Q	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Busulfan	DCK4JAP	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Aciclovir	DC8I14E	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Acetohydroxamic Acid	DCDE6QV	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oseltamivir + Cytarabine	DCJF285	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pepstatin + Oseltamivir	DC2POZL	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PF-02545920 + Oseltamivir	DCIVP4B	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PMID28460551-Compound-2 + Oseltamivir	DCNKW7O	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pramipexole + Oseltamivir	DC2BEJU	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Primidone + Oseltamivir	DCK5H32	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Sertraline + Oseltamivir	DCB8BZH	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Terazosin + Oseltamivir	DCACDRO	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Theophylline + Oseltamivir	DC947T8	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tiagabine + Oseltamivir	DCET73D	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trazodone + Oseltamivir	DCGJ51C	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triflupromazine + Oseltamivir	DCI48QX	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trihexyphenidyl + Oseltamivir	DCTIQYI	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trioxsalen + Oseltamivir	DC1M11M	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Ursodeoxycholic acid + Oseltamivir	DCGQ3GO	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
VR-776 + Oseltamivir	DCZIT6V	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
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⏷ Show the Full List of 79 DrugCom(s)

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nitazoxanide + Oseltamivir	DC46OTN	Nitazoxanide	Influenza	[5]
Oseltamivir + Probenecid	DCBUTRC	Probenecid	Influenza	[6]
Oseltamivir + Azithromycin	DCJCHFA	Azithromycin	COVID	[7]
Zanamivir + Oseltamivir	DC6LXUE	Zanamivir	Influenza	[8]
Dexamethasone + Oseltamivir	DC1K3VQ	Dexamethasone	Thrombocytopenia	[9]
Diltiazem + Oseltamivir	DCYSU14	Diltiazem	Flu	[10]
Celecoxib + Oseltamivir	DCWWHMP	Celecoxib	Influenza, Human	[11]
Lopinavir + Oseltamivir	DCMK65W	Lopinavir	Coronavirus Disease 2019 (COVID-19)	[12]
Oseltamivir + Azithromycin	DC1NHUI	Azithromycin	COVID 19	[13]
Oseltamivir + Hydroxychloroquine	DC4NSH5	Hydroxychloroquine	COVID 19	[13]
Oseltamivir + Azithromycin	DCT9TTY	Azithromycin	COVID 19	[13]
Oseltamivir + Darunavir	DC20895	Darunavir	Coronavirus Disease 2019 (COVID-19)	[12]
Oseltamivir + Ritonavir	DCUHJ5X	Ritonavir	Coronavirus Disease 2019 (COVID-19)	[3]
Oseltamivir + Ritonavir	DCE290N	Ritonavir	Coronavirus Disease 2019 (COVID-19)	[3]
Oseltamivir + Hydroxychloroquine	DCFWJ0U	Hydroxychloroquine	Coronavirus Disease 2019 (COVID-19)	[12]
Warfarin + Oseltamivir	DC1CVGE	Warfarin	Drug Therapy, Combination	[14]
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⏷ Show the Full List of 16 DrugCom(s)

References

1	Oseltamivir FDA Label
2	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3	ClinicalTrials.gov (NCT04261270) A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT01610245) Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
6	ClinicalTrials.gov (NCT00304434) Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies.
7	ClinicalTrials.gov (NCT04457609) Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients
8	ClinicalTrials.gov (NCT00921726) Pharmacokinetic Study of Oseltamivir and Intravenous Zanamivir in Healthy Adults
9	ClinicalTrials.gov (NCT01965626) A Multicenter Randomized Open-label Study of Oseltamivir Combined With HD-DEX Versus HD-DEX in the Management of ITP
10	ClinicalTrials.gov (NCT03212716) Efficiency of Antagonist Drugs of the Cellular Transcriptomic Signature of Influenza A Virus Infection.
11	ClinicalTrials.gov (NCT02108366) Treatment of Severe Influenza A Infection
12	ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial
13	ClinicalTrials.gov (NCT04338698) Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT
14	ClinicalTrials.gov (NCT02780622) A Pharmacokinetics, Pharmacodynamics and Safety Study of Warfarin in Combination With Tamiflu (Oseltamivir)