Details of the Drug Combinations

General Information of This Drug (ID: DMN3GCH)

Drug Name

Darunavir DMN3GCH

Synonyms

206361-99-1; TMC114; Prezista; TMC-114; UIC-94017; Darunavirum; TMC 114; Darunavirum [INN-Latin]; UNII-YO603Y8113; AIDS073035; CHEMBL1323; (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE; CHEBI:367163; Darunavir-d9; YO603Y8113; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate; NCGC00168773-01; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl; Darunavirum; Darunavir [USAN]; UIC 94017; Prezista(TM); UIC-96017; Darunavir (USAN/INN); Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester; {(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; [(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(330)oct-2-yloxy)carboxamide; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3-((4-aminobenzenesulfonyl)isobutylamino)-1-benzyl-2-hydroxypropyl)carbamic acid hexahydrofuro(2,3-b)furan-3-yl ester; (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]
Human immunodeficiency virus-1 infection	1C62	Phase 3	[2]
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Therapeutic Class

Antiviral Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

88 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetazolamide + Darunavir	DCF0NV3	Acetazolamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + Darunavir	DC0KD6C	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Darunavir	DCT8POG	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aprepitant + Darunavir	DCHH953	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Darunavir	DC6B175	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Darunavir	DCVFUOH	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Asenapine + Darunavir	DC3IF0L	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Atenolol + Darunavir	DC4RR8L	Atenolol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Darunavir	DCIY7DF	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Darunavir	DC591EQ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Darunavir	DCPNKEA	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clopidogrel + Darunavir	DC7SS7A	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Darunavir	DCTBN6Z	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Primidone	DCWJN1Z	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Gefitinib	DCVKPVE	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Dantrolene	DCLJKFG	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Citalopram	DC0S950	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Chlorphenesin	DCVJN4J	Chlorphenesin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + PMID28460551-Compound-2	DC0QTVU	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Vinblastine	DC2IV2X	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Mephenytoin	DC9CVQ4	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Anamorelin	DCS8SEX	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Pepstatin	DCFW05A	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Methylergonovine	DC7M0TP	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + SCH 727965	DCIJDIO	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Doxapram	DC4X9RS	Doxapram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Daidzin	DCBUWXU	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Clopidogrel	DCKG8GR	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Pentamidine	DC4Y5CN	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Tolazoline	DCDGPYE	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Isoproterenol	DCSTFDL	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Trifluoperazine	DCXTKF0	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Idarubicin	DCPATPU	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Darunavir + Linagliptin	DCL5GX7	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Pramipexole	DCRZ5X6	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Methylene blue	DC2JVSO	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Clascoterone	DCVJK9Q	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Trimethobenzamide	DCU3I4V	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Enalaprilat	DCUKSRP	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Maprotiline	DCSMV6O	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Oxyphenbutazone	DCTXEVW	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Acarbose	DCY5AFT	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Brincidofovir	DCBYBNJ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Maraviroc	DC0HZXQ	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Mycophenolic acid	DC5KHDZ	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Nabilone	DCM2HHH	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + PMID28870136-Compound-43	DCVMEAK	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Enoxacin	DCTS9KA	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + GSK2194069	DCXYJUI	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Ruxolitinib	DC6S8YC	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Diethylcarbamazine + Darunavir	DCIKXRY	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Darunavir	DC9ZTDG	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Darunavir	DC8T8XK	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Darunavir	DCVAEL8	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Darunavir	DCDRZNV	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Darunavir	DC9LJ0Z	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethinyl estradiol + Darunavir	DC17C6R	Ethinyl estradiol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
ETHISTERONE + Darunavir	DCJZVFX	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Darunavir	DCJAU9K	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fenoprofen + Darunavir	DCIG7PJ	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fibrates + Darunavir	DC3GYVQ	Fibrates	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Darunavir	DCJN88W	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
FORMESTANE + Darunavir	DC2XVIF	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Darunavir	DCVVZ7Q	Galantamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Darunavir	DC1MSSQ	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Darunavir	DCJ8NZ4	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lefaxin + Darunavir	DCNLJL4	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Darunavir	DCDW9JN	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Meclofenamic acid + Darunavir	DCD414O	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Darunavir	DCTMW9M	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
ML323 + Darunavir	DCN7UEV	ML323	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Norcisapride + Darunavir	DCK01FV	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Darunavir	DCWAADF	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olmesartan medoxomil + Darunavir	DCURYMB	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pamidronate + Darunavir	DC1YGJN	Pamidronate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pazopanib HCl + Darunavir	DC43DKJ	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Darunavir	DC9BDF6	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pomalidomide + Darunavir	DC0L9R1	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Repaglinide + Darunavir	DCU8J0W	Repaglinide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Silver sulfadiazine + Darunavir	DCKUXVP	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sivelestat + Darunavir	DCQRKWD	Sivelestat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + Darunavir	DCYMOMF	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tiagabine + Darunavir	DCXEP8Z	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triiodothyronine + Darunavir	DCWIPDL	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tropisetron + Darunavir	DCJKBAM	Tropisetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ursodeoxycholic acid + Darunavir	DCQREJA	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
WAY-100635 + Darunavir	DC5627T	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Darunavir	DCEVAXO	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 88 DrugCom(s)

21 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Darunavir + Ritonavir	DC5SGDX	Ritonavir	HIV-1	[5]
Darunavir + Raltegravir	DC6DLN4	Raltegravir	HIV-1 Infection	[6]
Darunavir + Daclatasvir	DCWAMCZ	Daclatasvir	Hepatitis C	[7]
Emtricitabine + Darunavir	DC0YJIS	Emtricitabine	HIV Infections	[8]
Etravirine + Darunavir	DC7ZBPE	Etravirine	HIV Infections	[9]
Etravirine + Darunavir	DCV1JJ5	Etravirine	HIV-1 Infection	[6]
Etravirine + Darunavir	DCPI6UX	Etravirine	HIV/AIDS	[10]
Pitavastatin + Darunavir	DCJ3HP0	Pitavastatin	Hyperlipidemia	[11]
Darunavir + Maraviroc	DCPAGJO	Maraviroc	HIV-1 Infection	[12]
Etravirine + Darunavir	DC5AHVN	Etravirine	Human Immunodeficiency Virus (HIV)	[13]
Cobicistat + Darunavir	DCL4TNM	Cobicistat	Coronavirus Disease 2019 (COVID-19)	[14]
Dolutegravir + Darunavir	DCGBRQN	Dolutegravir	HIV-Infection	[15]
Favipiravir + Darunavir	DCJ0NU2	Favipiravir	Coronavirus Disease 2019 (COVID-19)	[16]
Oseltamivir + Darunavir	DC20895	Oseltamivir	Coronavirus Disease 2019 (COVID-19)	[16]
Cobicistat + Darunavir	DCGBGII	Cobicistat	AIDS-related Dementia Complex	[17]
Darunavir + Ritonavir	DCFSHIX	Ritonavir	HIV Infections	[18]
Dolutegravir + Darunavir	DCFT2DA	Dolutegravir	HIV-infection/Aids	[19]
Dolutegravir + Darunavir	DCNCFTE	Dolutegravir	HIV Infections	[20]
Emtricitabine + Darunavir	DCDM84V	Emtricitabine	HIV	[21]
Etravirine + Darunavir	DC8931X	Etravirine	Acute HIV Infection	[22]
Lamivudine + Darunavir	DC7TBXK	Lamivudine	Patient Compliance	[23]
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⏷ Show the Full List of 21 DrugCom(s)

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cobicistat + Darunavir	DC2HCN2	Cobicistat	Human immunodeficiency virus infection	[24]
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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT00355524) A Phase 2 Study to Evaluate Pharmacokinetics, Safety and Efficacy of TMC114/Ritonavir (Rtv) in Human Immunodeficiency Virus (HIV)-1 Infected Children and Adolescents
6	ClinicalTrials.gov (NCT01641367) A5288/MULTI-OCTAVE: Management Using Latest Technologies to Optimize Combination Therapy After Viral Failure
7	ClinicalTrials.gov (NCT02159352) Study Assessing the Effects of Darunavir/Ritonavir or Lopinavir/Ritonavir on the Pharmacokinetics of Daclatasvir in Healthy Participants
8	ClinicalTrials.gov (NCT00525733) Standard Antiretroviral v. Multi-class Therapy in Acutely HIV-1 Infected Antiretroviral-Nave Subjects (ADARC 2007-01)
9	ClinicalTrials.gov (NCT00977756) IMPAACT P1058A: Pharmacokinetic Effects of New Antiretroviral Drugs on Children, Adolescents and Young Adults
10	ClinicalTrials.gov (NCT00855088) Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue
11	ClinicalTrials.gov (NCT01695954) Pharmacokinetic Study of Pitavastatin and Ritonavir-Boosted Darunavir or Efavirenz
12	ClinicalTrials.gov (NCT00993148) Maraviroc Plus Darunavir/Ritonavir for Treatment-Nave Patients Infected With R5-tropic HIV-1
13	ClinicalTrials.gov (NCT01199939) A Study of the Once Daily Combination of Etravirine and Darunavir/Ritonavir As Dual Therapy in Early Treatment-Experienced Patients
14	ClinicalTrials.gov (NCT04252274) Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19
15	ClinicalTrials.gov (NCT02486133) Dual Therapy With Boosted Darunavir + Dolutegravir
16	ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial
17	ClinicalTrials.gov (NCT02503462) Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals
18	ClinicalTrials.gov (NCT00677300) Raltegravir And Darunavir Antiretroviral in Antiretroviral Naive Patients
19	ClinicalTrials.gov (NCT04183738) Inflammation and Co-Infections in DEFT
20	ClinicalTrials.gov (NCT03017872) Dolutegravir and Darunavir Evaluation in Adults Failing Therapy
21	ClinicalTrials.gov (NCT00757783) Changes in Triglyceride and Other Lipids (Levels of Fats Found in Blood) When Taking Darunavir Compared to Atazanavir in HIV-infected Patients That Have Never Received Treatment
22	ClinicalTrials.gov (NCT00855413) HIV Viremia and Persistence in Acutely HIV-Infected Patients Treated With Darunavir/Ritonavir and Etravirine
23	ClinicalTrials.gov (NCT02470650) Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive
24	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015