Details of the Drug Combinations

General Information of This Drug (ID: DMOJZQ9)

• Drug Name: Loperamide (DMOJZQ9)
• Synonyms: Ioperamide; Loperacap; Loperamida; Loperamidum; Kaopectate II; Loperamide Monohydrochloride; Pepto Diarrhea Control; Apo-Loperamide; Diamide (TN); Diarr-Eze; Dimor (TN); Imodium (TN); Imodium A-D Caplets; Loperamida [INN-Spanish]; Loperamide (INN); Loperamide [INN:BAN]; Loperamidum [INN-Latin]; Lopex (TN); Maalox Anti-Diarrheal; Nu-Loperamide; PMS-Loperamide; Pepto (TN); R-18553; Rho-Loperamide

Indication

Diarrhea; ICD 11: ME05.1; Status: Approved [1]; Traveler's diarrhea; ICD 11: ME05.1; Status: Approved [2]; Middle East Respiratory Syndrome (MERS); ICD 11: 1D64; Status: Preclinical [3]; Severe acute respiratory syndrome (SARS); ICD 11: 1D65; Status: Preclinical [3]

• Therapeutic Class: Antidiarrheals
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Loperamide	DC2HS3G	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Brincidofovir + Loperamide	DC7PAJS	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cerivastatin + Loperamide	DCC4V10	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Docetaxel + Loperamide	DC0TN6B	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dronedarone + Loperamide	DCJUUCK	Dronedarone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Imatinib + Loperamide	DCY7Y1B	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Levamisole + Loperamide	DCGGXY4	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Gefitinib	DC9AFIS	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Terazosin	DCPUOMH	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Epinephrine	DC55MUO	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + PMID28460551-Compound-2	DC5O108	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Pazopanib HCl	DC8G9A9	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Fomepizole	DC39B55	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Ramelteon	DCIQWDU	Ramelteon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Triapine	DCQI568	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Everolimus	DCK40P4	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + BHV-0223	DC8VCKT	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Terameprocol	DCS60T3	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Chlorzoxazone	DC1WDDJ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + K-134	DCBEVRI	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + ETHISTERONE	DCSV7TG	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Aminosalicylic acid	DCEXRM1	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + PHA-739358	DCCAQXT	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Tolazoline	DCSQE49	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + BIO-300	DCIUEKY	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Tiagabine	DCD5CXE	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Entacapone	DC1CKBJ	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Allopurinol	DCEI3L1	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Benserazide	DC8CC5I	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Idarubicin	DCRKQQH	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + BRL-15572	DCD15US	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Bortezomib	DC16U2V	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Methylene blue	DCL0VIZ	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Artemisinin	DCTE6JU	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Maprotiline	DC75YO1	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Teriflunomide	DCVI721	Teriflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Theophylline	DCKCPEL	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Chlorambucil	DCK588W	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Hydralazine	DC5DLFJ	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Cisatracurium	DCEZBJA	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Lacosamide	DCBAN9W	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Doxorubicin	DCAIF8X	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Olmesartan medoxomil	DCMDWIY	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Cerivastatin	DCNR62L	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Metaxalone	DCNBGT9	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + ML323	DC36P8M	ML323	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Cytarabine	DC3EVW6	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mebutamate + Loperamide	DC1RMA6	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mycophenolic acid + Loperamide	DC1MHYX	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Oxyphenbutazone + Loperamide	DCQSPXS	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PF-02545920 + Loperamide	DCGJDNI	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pramipexole + Loperamide	DC1D2F1	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tamoxifen + Loperamide	DC9J5PE	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tropisetron + Loperamide	DC60ON5	Tropisetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Vinblastine + Loperamide	DCU16PG	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sulfasalazine + Loperamide	DC6ZN1P	Sulfasalazine	Intestinal Obstruction	[5]
HKI-272 + Loperamide	DCS2X5I	HKI-272	HER2 Amplified Breast Cancer	[6]
HKI-272 + Loperamide	DCCTNYH	HKI-272	Early Stage HER2+ Breast Cancer	[7]
Vancomycin + Loperamide	DCHTNFE	Vancomycin	Clostridium Difficile Infection	[8]
Loperamide + Afatinib	DC7944X	Afatinib	Carcinoma, Non-Small-Cell Lung	[9]
Azithromycin + Loperamide	DCQNL2R	Azithromycin	Diarrhoea;Acute	[10]
Loperamide + Rifaximin	DC0NCNQ	Rifaximin	Diarrhoea;Acute	[10]
Loperamide + Simethicone	DC1RF6P	Simethicone	Relapsing Remitting Multiple Sclerosis	[11]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Loperamide FDA Label
• [3] Screening of an FDA-approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84.
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT01596764) Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
• [6] ClinicalTrials.gov (NCT04366713) A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib
• [7] ClinicalTrials.gov (NCT02400476) An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide
• [8] ClinicalTrials.gov (NCT02686645) Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection
• [9] ClinicalTrials.gov (NCT01814553) ADAM-Afatinib Diarrhea Assessment and Management
• [10] ClinicalTrials.gov (NCT05677282) Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct
• [11] ClinicalTrials.gov (NCT02217982) Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation