Details of the Drug Combinations

General Information of This Drug (ID: DMU764S)

Drug Name

Ritonavir DMU764S

Synonyms

Norvir; RIT; RTV; Norvir Sec; Ritonavir [USAN]; ABT 538; ABT 84538; ABT538; Abbott 84538; A-84538; ABBOTT-84538; ABT-538; DRG-0244; Norvir (TM); Norvir (TN); Ritonavir (JAN/USAN/INN); N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide; 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 538, ABT

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]
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Therapeutic Class

Anti-HIV Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

23 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dihydroergotamine + Ritonavir	DCOYB3J	Dihydroergotamine	DD2 (Cell Line: DD2)	[2]
Dihydroergotamine + Ritonavir	DCIOUJD	Dihydroergotamine	Hepatoblastoma (Cell Line: HB3)	[2]
Lopinavir + Ritonavir	DCCA3OM	Lopinavir	Middle East Respiratory Syndrome (MERS) (Cell Line: .)	[3]
Miconazole + Ritonavir	DCVC590	Miconazole	Hepatoblastoma (Cell Line: HB3)	[4]
Nitisinone + Ritonavir	DCPMM91	Nitisinone	Hepatoblastoma (Cell Line: HB3)	[2]
Omacetaxine mepesuccinate + Ritonavir	DCCRW3I	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[4]
Ritonavir + OZ277	DCAEURP	OZ277	DD2 (Cell Line: DD2)	[2]
Ritonavir + Lumefantrine	DC12V1J	Lumefantrine	DD2 (Cell Line: DD2)	[2]
Ritonavir + Lumefantrine	DCA8G3Z	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + Diltiazem	DCMSR02	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + Thiolactomycin	DCTWCLT	Thiolactomycin	DD2 (Cell Line: DD2)	[2]
Ritonavir + Thiolactomycin	DCSYDMF	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + Docetaxel	DC0G7CG	Docetaxel	DD2 (Cell Line: DD2)	[2]
Ritonavir + Idarubicin	DCT1XQN	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Ritonavir + Epothilone B	DCSJO2R	Epothilone B	DD2 (Cell Line: DD2)	[2]
Ritonavir + Epothilone B	DCHGV84	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + MK-4815	DC3MXAG	MK-4815	DD2 (Cell Line: DD2)	[2]
Ritonavir + MK-4815	DCMUMUW	MK-4815	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + Mefloquine	DC9O4OW	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[2]
Ritonavir + Atovaquone	DC4J90I	Atovaquone	DD2 (Cell Line: DD2)	[2]
SB 228357 + Ritonavir	DCF6NVM	SB 228357	DD2 (Cell Line: DD2)	[2]
SB 228357 + Ritonavir	DCF70AB	SB 228357	Hepatoblastoma (Cell Line: HB3)	[4]
Sorafenib + Ritonavir	DCH0OM5	Sorafenib	Hepatoblastoma (Cell Line: HB3)	[2]
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⏷ Show the Full List of 23 DrugCom(s)

26 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atazanavir + Ritonavir	DCKM8IJ	Atazanavir	HIV Infections	[5]
Atazanavir + Ritonavir	DCBXVIY	Atazanavir	HIV	[6]
Atazanavir + Ritonavir	DCUIOGY	Atazanavir	Human Immunodeficiency Virus Type 1 (HIV-1)	[7]
ATEVIRDINE + Ritonavir	DCNDD1M	ATEVIRDINE	HIV Infections	[8]
Avanafil + Ritonavir	DCR1VBX	Avanafil	Erectile Dysfunction	[9]
Darunavir + Ritonavir	DC5SGDX	Darunavir	HIV-1	[10]
Fosamprenavir + Ritonavir	DCQVQ04	Fosamprenavir	HIV Infection	[11]
Itraconazole + Ritonavir	DCPNBQ9	Itraconazole	HER2-positive Advanced Solid Tumor	[12]
Lopinavir + Ritonavir	DCDVYC4	Lopinavir	Brain Tumor	[13]
Paritaprevir + Ritonavir	DCX4D34	Paritaprevir	HCV Infection	[14]
Relugolix + Ritonavir	DCEVAMU	Relugolix	Prostate Cancer	[15]
Ritonavir + AMD-070	DCKPDCJ	AMD-070	HIV Infections	[16]
Samatasvir + Ritonavir	DCP08LB	Samatasvir	Chronic Hepatitis C Infection	[17]
Saquinavir + Ritonavir	DCQM6CM	Saquinavir	HIV Infections	[18]
Sitaxsentan + Ritonavir	DCSOOKH	Sitaxsentan	Pulmonary Arterial Hypertension	[19]
Tipranavir + Ritonavir	DC4RNB0	Tipranavir	HIV Infections	[20]
Danoprevir + Ritonavir	DCMIAKM	Danoprevir	Coronavirus Disease 2019 (COVID-19)	[21]
Danoprevir + Ritonavir	DCKMHP3	Danoprevir	Coronavirus Disease 2019 (COVID-19)	[21]
Lonafarnib + Ritonavir	DCLZJ2K	Lonafarnib	Hepatitis D	[22]
Lonafarnib + Ritonavir	DCYZ8TN	Lonafarnib	Chronic Hepatitis D Infection	[23]
Lopinavir + Ritonavir	DC1SBRY	Lopinavir	Coronavirus Disease 2019 (COVID-19)	[24]
Oseltamivir + Ritonavir	DCUHJ5X	Oseltamivir	Coronavirus Disease 2019 (COVID-19)	[25]
Oseltamivir + Ritonavir	DCE290N	Oseltamivir	Coronavirus Disease 2019 (COVID-19)	[25]
Ritonavir + TMC-310911	DCIXYF9	TMC-310911	Coronavirus Disease 2019 (COVID-19)	[26]
Atazanavir + Ritonavir	DCRZS8N	Atazanavir	HIV, Combination Therapy	[27]
Darunavir + Ritonavir	DCFSHIX	Darunavir	HIV Infections	[28]
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⏷ Show the Full List of 26 DrugCom(s)

References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT00977756) IMPAACT P1058A: Pharmacokinetic Effects of New Antiretroviral Drugs on Children, Adolescents and Young Adults
6	ClinicalTrials.gov (NCT01335698) Phase IIIB Study Evaluating the Effects of Atazanavir Powder With Ritonavir in HIV-infected Pediatric Patients
7	ClinicalTrials.gov (NCT00833482) Drug Interactions Between Voriconazole and Atazanavir Coadministered as Atazanavir/Ritonavir in Healthy Participants
8	ClinicalTrials.gov (NCT00006604) Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents
9	ClinicalTrials.gov (NCT00770042) To Evaluate The Effect Of Ketoconazole, Ritonavir and Erythromycin on the Safety and Pharmacokinetics of Avanafil
10	ClinicalTrials.gov (NCT00355524) A Phase 2 Study to Evaluate Pharmacokinetics, Safety and Efficacy of TMC114/Ritonavir (Rtv) in Human Immunodeficiency Virus (HIV)-1 Infected Children and Adolescents
11	ClinicalTrials.gov (NCT00040664) A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years
12	ClinicalTrials.gov (NCT05150691) A Study of DB-1303 in Advanced/Metastatic Solid Tumors
13	ClinicalTrials.gov (NCT01095094) Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
14	ClinicalTrials.gov (NCT00850044) Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1
15	ClinicalTrials.gov (NCT05679388) A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients
16	ClinicalTrials.gov (NCT00063804) Safety of AMD070 When Administered Alone or Boosted With Low-Dose Ritonavir in HIV Uninfected Men
17	ClinicalTrials.gov (NCT01813552) To Evaluate the Effect of Ritonavir or Omeprazole on the Pharmacokinetics of Samatasvir (IDX719) in Healthy Participants (MK-1894-006). U.S. National Institutes of Health.
18	ClinicalTrials.gov (NCT00435929) A Study of Saquinavir/Ritonavir in Liver-Impaired Patients With HIV Infection.
19	ClinicalTrials.gov (NCT01251848) Drug Interaction Between Ritonavir And Sitaxsentan
20	ClinicalTrials.gov (NCT00531206) Observational Non-interventional Study (Anwendungsbeobachtung) With Aptivus (Tipranavir) in HIV-infected Patients.
21	ClinicalTrials.gov (NCT04291729) Evaluation of Ganovo Danoprevir Combined With Ritonavir in the Treatment of SARS-CoV-2 Infection
22	ClinicalTrials.gov (NCT02511431) Treatment of Chronic Delta Hepatitis With Lonafarnib and Ritonavir
23	ClinicalTrials.gov (NCT02430181) Lonafarnib With and Without Ritonavir in HDV (LOWR-1)
24	ClinicalTrials.gov (NCT04315948) Trial of Treatments for COVID-19 in Hospitalized Adults
25	ClinicalTrials.gov (NCT04261270) A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia
26	ClinicalTrials.gov (NCT04261907) Evaluating and Comparing the Safety and Efficiency of ASC09/Ritonavir and Lopinavir/Ritonavir for Novel Coronavirus Infection
27	ClinicalTrials.gov (NCT01332227) Atazanavir/Ritonavir, Once Daily + Raltegravir, Twice Daily, Switch Study in HIV-1-Infected Patients
28	ClinicalTrials.gov (NCT00677300) Raltegravir And Darunavir Antiretroviral in Antiretroviral Naive Patients