Details of the Drug Combinations

General Information of This Drug (ID: DMY4UMW)

Drug Name
Atovaquone   DMY4UMW
Synonyms
Acuvel; Atavaquone; Mepron; Pron; Wellvone; Atovaquone GlaxoSmithKline brand; Glaxo Wellcome brand of atovaquone; GlaxoSmithKline brand of atovaquone; Malarone Pediatric; BW 566C; BW 566C80; Hydroxynaphthoquinone 566C80; Atovaquone & Interleukin 12; BW 556C-80; BW 566C-80; BW-A 566C; DRG-0084; Hydroxynaphthoquinone, 566C80; Mepron (TN); Mepron (antipneumocystic); ATO & IL-12; Atovaquone (USP/INN); Atovaquone [USAN:BAN:INN]; CRL-8131 & Atovaquone; 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; 2-(4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; 2-(trans-4-(p-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone; 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione; 2-[trans-4-(p-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone; 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione; 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione; 566C80 hydroxynaphthoquinone; 566C80, hydroxynaphthoquinone; ATQ
Indication
Disease Entry ICD 11 Status REF
Fungal infection 1F29-1F2F Approved [1]
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

142 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohexamide + Atovaquone DCUQULP Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Alvespimycin hydrochloride + Atovaquone DC3GEXQ Alvespimycin hydrochloride DD2 (Cell Line: DD2) [2]
Arfolitixorin + Atovaquone DCB4046 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemisinin + Atovaquone DCGHQG0 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Baclofen DCI375Z Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Clindamycin DCCIX13 Clindamycin Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Dantrolene DC47KDZ Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Diethylcarbamazine DCGYEJS Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + OZ277 DC5HS54 OZ277 DD2 (Cell Line: DD2) [2]
Atovaquone + OZ277 DC61777 OZ277 Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Lumefantrine DCEUC62 Lumefantrine DD2 (Cell Line: DD2) [2]
Atovaquone + Lumefantrine DCBX116 Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Citalopram DC444WL Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Furazolidone DCQTIMD Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Artemether DCTVOX9 Artemether Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Doxycycline DC24339 Doxycycline Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Diltiazem DC62BDB Diltiazem DD2 (Cell Line: DD2) [2]
Atovaquone + Proguanil DC3AZ8F Proguanil DD2 (Cell Line: DD2) [2]
Atovaquone + Metyrosine DCZMX7L Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Efavirenz DCPBPWX Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Elesclomol DCYTP28 Elesclomol Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Biperiden DCUEFAI Biperiden Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Sitagliptin DCVV2S2 Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + BREQUINAR DC1KHX4 BREQUINAR DD2 (Cell Line: DD2) [2]
Atovaquone + Idarubicin DCQ6KOX Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Atovaquone + Methylene blue DC1W2W5 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Methylene blue DC75D6M Methylene blue Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Artemisinin DCZLWQ9 Artemisinin DD2 (Cell Line: DD2) [2]
Atovaquone + Artemisinin DCFUHW2 Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Maprotiline DCT5NWS Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + NITD609 DC39YHN NITD609 DD2 (Cell Line: DD2) [2]
Atovaquone + Leflunomide DCG6T7K Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Amiloride DCYRI6I Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Brincidofovir DCJTZFB Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Clomiphene citrate DC6F63Q Clomiphene citrate DD2 (Cell Line: DD2) [2]
Atovaquone + Clomiphene citrate DCRCKUM Clomiphene citrate Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Chloroquine DC9HXI7 Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Hyodeoxycholic acid DCFRXTL Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Naltrexone DCBHRFK Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Piperaquine DCR7HR4 Piperaquine DD2 (Cell Line: DD2) [2]
Atovaquone + Piperaquine DCRRKSK Piperaquine Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + NVP-AUY922 DCP2I2N NVP-AUY922 Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Cyclosporin A DCME91O Cyclosporin A DD2 (Cell Line: DD2) [2]
Atovaquone + Nitisinone DCX5GCE Nitisinone DD2 (Cell Line: DD2) [2]
Atovaquone + Nitisinone DC47AAF Nitisinone Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + Cerivastatin DCIVQJV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Busulfan DCXU0R3 Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Atovaquone DCCX4OT Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + GDC-0077 DCLMT5N GDC-0077 Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + ML323 DC90GMX ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bafilomycin A1 + Atovaquone DCTOJ27 Bafilomycin A1 Hepatoblastoma (Cell Line: HB3) [3]
Berberine + Atovaquone DCO0NXC Berberine DD2 (Cell Line: DD2) [2]
Berberine + Atovaquone DCEL2D9 Berberine Hepatoblastoma (Cell Line: HB3) [3]
BGT226 + Atovaquone DC9RKEG BGT226 DD2 (Cell Line: DD2) [2]
Bifemelane + Atovaquone DCMIEMS Bifemelane DD2 (Cell Line: DD2) [2]
Bifemelane + Atovaquone DCSW1SA Bifemelane Hepatoblastoma (Cell Line: HB3) [3]
BIO-300 + Atovaquone DCEVCNN BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Atovaquone DCVVSYB Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BREQUINAR + Atovaquone DC223XE BREQUINAR Hepatoblastoma (Cell Line: HB3) [3]
Brincidofovir + Atovaquone DC7B64I Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Carfilzomib + Atovaquone DCJAU51 Carfilzomib Hepatoblastoma (Cell Line: HB3) [2]
Cinacalcet + Atovaquone DCI72JS Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ciprofibrate + Atovaquone DCZWVRI Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Citalopram + Atovaquone DCK5JB5 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Atovaquone DCANWII Clindamycin DD2 (Cell Line: DD2) [2]
Clindamycin + Atovaquone DCITQZH Clindamycin Hepatoblastoma (Cell Line: HB3) [2]
Dichlorphenamide + Atovaquone DCT8FCF Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dihydroergotamine + Atovaquone DC6EAOO Dihydroergotamine DD2 (Cell Line: DD2) [2]
Dihydroergotamine + Atovaquone DCE9SXH Dihydroergotamine Hepatoblastoma (Cell Line: HB3) [2]
Docetaxel + Atovaquone DC407GM Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxepin + Atovaquone DCA1W65 Doxepin DD2 (Cell Line: DD2) [2]
Doxorubicin + Atovaquone DCCLH0Q Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eltanexor oral + Atovaquone DCNZGH8 Eltanexor oral DD2 (Cell Line: DD2) [2]
Eltanexor oral + Atovaquone DCWYE90 Eltanexor oral Hepatoblastoma (Cell Line: HB3) [3]
Emetine + Atovaquone DCX08VG Emetine DD2 (Cell Line: DD2) [2]
Epinephrine + Atovaquone DC7951C Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epothilone B + Atovaquone DCPIXWQ Epothilone B Hepatoblastoma (Cell Line: HB3) [3]
Eptifibatide + Atovaquone DC2KM4M Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fenoprofen + Atovaquone DC1KG3Q Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Atovaquone DCKD960 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gentian violet + Atovaquone DCIOQ2H Gentian violet DD2 (Cell Line: DD2) [2]
Gentian violet + Atovaquone DC2LOD8 Gentian violet Hepatoblastoma (Cell Line: HB3) [3]
Imatinib + Atovaquone DCSMTCW Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Atovaquone DCBOH6D IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ivermectin + Atovaquone DCK7N2I Ivermectin DD2 (Cell Line: DD2) [2]
JTC-801 + Atovaquone DCWZFHQ JTC-801 DD2 (Cell Line: DD2) [2]
JTC-801 + Atovaquone DCXE30Q JTC-801 Hepatoblastoma (Cell Line: HB3) [2]
KN-62 + Atovaquone DC25VEX KN-62 DD2 (Cell Line: DD2) [2]
KN-62 + Atovaquone DCLFLLY KN-62 Hepatoblastoma (Cell Line: HB3) [3]
Lumefantrine + Atovaquone DC49E4K Lumefantrine DD2 (Cell Line: DD2) [2]
Lumefantrine + Atovaquone DC53RUQ Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Mefloquine + Atovaquone DC7AZC0 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Atovaquone DCM662B Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Methotrexate + Atovaquone DC84L5U Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Atovaquone DC5Z6Z3 Methotrexate DD2 (Cell Line: DD2) [2]
Methotrexate + Atovaquone DCYQK2L Methotrexate Hepatoblastoma (Cell Line: HB3) [2]
Miconazole + Atovaquone DC2WKJI Miconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miconazole + Atovaquone DC6A8NA Miconazole DD2 (Cell Line: DD2) [2]
Miconazole + Atovaquone DCUWOIO Miconazole Hepatoblastoma (Cell Line: HB3) [3]
Midostaurin + Atovaquone DCNZBXO Midostaurin DD2 (Cell Line: DD2) [2]
MK-4815 + Atovaquone DCU9GXV MK-4815 DD2 (Cell Line: DD2) [2]
MK-4815 + Atovaquone DCYNSFK MK-4815 Hepatoblastoma (Cell Line: HB3) [3]
Mycophenolic acid + Atovaquone DCVL68L Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
NITD609 + Atovaquone DC3OYNW NITD609 DD2 (Cell Line: DD2) [2]
NITD609 + Atovaquone DCPX591 NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Nitisinone + Atovaquone DC5P6RS Nitisinone DD2 (Cell Line: DD2) [2]
Nitisinone + Atovaquone DCUE3R1 Nitisinone Hepatoblastoma (Cell Line: HB3) [2]
Norcisapride + Atovaquone DCWOJV5 Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
NVP-AUY922 + Atovaquone DC6TCVC NVP-AUY922 DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + Atovaquone DCNLSJW Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + Atovaquone DCWMFGF Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [3]
Oxyphenbutazone + Atovaquone DCJ3SDE Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Panobinostat + Atovaquone DCNHC4Q Panobinostat DD2 (Cell Line: DD2) [2]
Panobinostat + Atovaquone DCNW81T Panobinostat Hepatoblastoma (Cell Line: HB3) [3]
Pinacidil + Atovaquone DCOKUMT Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Piperaquine + Atovaquone DCLS5SZ Piperaquine DD2 (Cell Line: DD2) [2]
Piperaquine + Atovaquone DC8PYDC Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
PMID28870136-Compound-43 + Atovaquone DCOHZW4 PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Proguanil + Atovaquone DCGGLYU Proguanil DD2 (Cell Line: DD2) [2]
Proguanil + Atovaquone DC359JS Proguanil Hepatoblastoma (Cell Line: HB3) [2]
Pyrazinamide + Atovaquone DC03WQZ Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrimethamine + Atovaquone DCRO09I Pyrimethamine DD2 (Cell Line: DD2) [2]
Pyrimethamine + Atovaquone DCBSQQ2 Pyrimethamine Hepatoblastoma (Cell Line: HB3) [2]
Pyronaridine + Atovaquone DC0J9I7 Pyronaridine DD2 (Cell Line: DD2) [2]
Pyronaridine + Atovaquone DCY8FO9 Pyronaridine Hepatoblastoma (Cell Line: HB3) [3]
Ritonavir + Atovaquone DC4J90I Ritonavir DD2 (Cell Line: DD2) [2]
Sarpogrelate + Atovaquone DCL7PCN Sarpogrelate DD2 (Cell Line: DD2) [2]
Sarpogrelate + Atovaquone DC2B93L Sarpogrelate Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Atovaquone DCRZ57M SB 228357 DD2 (Cell Line: DD2) [2]
SB 228357 + Atovaquone DC1J3OG SB 228357 Hepatoblastoma (Cell Line: HB3) [3]
Sorafenib + Atovaquone DCEI834 Sorafenib Hepatoblastoma (Cell Line: HB3) [2]
T-3.5 + Atovaquone DCP4CIA T-3.5 DD2 (Cell Line: DD2) [2]
Thiolactomycin + Atovaquone DCFAATL Thiolactomycin DD2 (Cell Line: DD2) [2]
Tiagabine + Atovaquone DCKIKP1 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Atovaquone DC6Q2M6 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trichostatin A + Atovaquone DC5WWO2 Trichostatin A DD2 (Cell Line: DD2) [2]
Triflupromazine + Atovaquone DCDWEQM Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Atovaquone DC3W1AZ Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trioxsalen + Atovaquone DCZJRPL Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Verapamil + Atovaquone DCK9CIM Verapamil DD2 (Cell Line: DD2) [3]
Vorinostat + Atovaquone DCSPEJ3 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ZM-447439 + Atovaquone DC5TBBZ ZM-447439 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 142 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Vinorelbine + Atovaquone DCI3BRO Vinorelbine Locally Advanced Non-Small Cell Lung Cancer [4]
Azithromycin + Atovaquone DCTKUJS Azithromycin Coronavirus Disease 2019 (COVID-19) [5]
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References

1 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT04648033) Atovaquone With Radical ChemorADIotherapy in Locally Advanced NSCLC
5 ClinicalTrials.gov (NCT04339426) Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection. U.S. National Institutes of Health.