Details of the Drug Combinations

General Information of This Drug (ID: DMZ7XNQ)

Drug Name
Tacrolimus   DMZ7XNQ
Synonyms
Advagraf; Fujimycin; Graceptor; Modigraf; Prograf; Protopic; Protopy; Tacarolimus; Tsukubaenolide; Tacrolimus anhydrous; FK 506; FK5; FK506; FR 900506; FR900506; K506; L 679934; Advagraf (TN); FR-900506; Fk-506; L-679934; LCP-Tacro; Prograf (TN); Protopic (TN); Tacrolimus (INN); Tacrolimus (Prograf); Tacrolimus (anhydrous); (-)-FK 506; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Indication
Disease Entry ICD 11 Status REF
Graft-versus-host disease 4B24 Approved [1]
Hepatosplenic T-cell lymphoma N.A. Approved [1]
Kidney transplant rejection NE84 Approved [1]
Large granular lymphocytic leukemia 2A90.1 Approved [1]
Leukemia N.A. Approved [1]
Lupus nephritis 4A40.0Y Approved [1]
MALT lymphoma N.A. Approved [1]
Myeloproliferative neoplasm 2A20 Approved [1]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Organ transplant rejection NE84 Approved [2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Small intestine lymphoma N.A. Approved [1]
Splenic marginal zone lymphoma N.A. Approved [1]
Testicular lymphoma N.A. Approved [1]
Ocular allergy 4A81 Phase 3 [2]
Classic Hodgkin lymphoma N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Immunosuppressive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohydroxamic Acid + Tacrolimus DCAWGRA Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Albendazole + Tacrolimus DC6DZ66 Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Aliskiren + Tacrolimus DCM51U0 Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Anamorelin + Tacrolimus DCD2DGU Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Tacrolimus DC4BGBN Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Tacrolimus DC9R6VG BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Tacrolimus DCCNRKP Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Tacrolimus DCOJUQV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cevimeline + Tacrolimus DCZYNJ3 Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Tacrolimus DCKWX1G Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Tacrolimus DC8I207 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Tacrolimus DC9KP78 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Etomidate + Tacrolimus DCTP1N3 Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Tacrolimus DCTB9F9 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Tacrolimus DCG3DV1 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Galantamine + Tacrolimus DCYTN91 Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Tacrolimus DCMTSJQ Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Tacrolimus DCN5THK IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Tacrolimus DCOM1T2 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Tacrolimus DCE81TA Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pepstatin + Tacrolimus DCVECWT Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Tacrolimus DCE19E1 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pramipexole + Tacrolimus DCOV4V4 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Tacrolimus DCUCC99 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Silver sulfadiazine + Tacrolimus DCC02C4 Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sivelestat + Tacrolimus DC5IDVD Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Dantrolene DCM1U40 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Epinephrine DCZAX1F Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Vinblastine DCDAU7N Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Triapine DCLRCYF Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Buspirone DC0PDRF Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Metyrosine DC74A6R Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Docetaxel DCHFDN8 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Sulfinpyrazone DCJBTG6 Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + PF-02545920 DCA0G6B PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Imatinib DCJG69B Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Bortezomib DC8T6CI Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Mesalazine DCMHN5U Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Artemisinin DCHK9S7 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Brincidofovir DC6LWBA Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Quinine DCO6VHS Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Mycophenolic acid DCFBDYN Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Lacosamide DCEIJM5 Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tacrolimus + Auranofin DCKL783 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Tacrolimus DC8O60Q Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolvaptan + Tacrolimus DCAL2YR Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Tacrolimus DC4SECJ Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trimethobenzamide + Tacrolimus DCKAJ2S Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 48 DrugCom(s)
22 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Apixaban + Tacrolimus DCVQ929 Apixaban Venous Thromboembolism [4]
Carfilzomib + Tacrolimus DCEMT1F Carfilzomib Hematologic Malignancies [5]
Cyclosporin A + Tacrolimus DC516KQ Cyclosporin A Skin Cancer [6]
Cyclosporin A + Tacrolimus DC9ZTCF Cyclosporin A End-Stage Renal Disease [7]
Isavuconazole + Tacrolimus DCCM5ID Isavuconazole Pharmacokinetics of Isavuconazole [8]
Methotrexate + Tacrolimus DCBITQN Methotrexate Leukemia, Myelocytic, Acute [9]
Methotrexate + Tacrolimus DCMBK7X Methotrexate Graft Versus Host Disease [10]
Mycophenolate mofetil + Tacrolimus DC7MMEK Mycophenolate mofetil Liver Dysfunction [11]
Mycophenolate mofetil + Tacrolimus DCMZP3N Mycophenolate mofetil Accelerated Phase Chronic Myelogenous Leukemia [12]
Mycophenolic acid + Tacrolimus DC33EJM Mycophenolic acid Liver Transplantation [13]
Mycophenolic acid + Tacrolimus DCINLK5 Mycophenolic acid Chronic Allograft Injury [14]
Telaprevir + Tacrolimus DCBQPX7 Telaprevir Hepatitis C [15]
Azathioprine + Tacrolimus DCO82YN Azathioprine Uterine Factor Infertility [16]
Bortezomib + Tacrolimus DC5I8Y5 Bortezomib Acute Leukemia [17]
Cyclophosphamide + Tacrolimus DCCFQRU Cyclophosphamide Graft Vs Host Disease [18]
Dexamethasone + Tacrolimus DCDTJWS Dexamethasone Pharmacological Action [19]
Everolimus + Tacrolimus DCWJNC3 Everolimus Delayed Graft Function [20]
Prednisolone + Tacrolimus DC8M9Z3 Prednisolone Sjogren Syndrome With Other Organ Involvement [21]
Everolimus + Tacrolimus DC8BWRX Everolimus Liver Transplantation [22]
Indomethacin + Tacrolimus DCWGHF4 Indomethacin Post-ERCP Acute Pancreatitis [23]
Mycophenolic acid + Tacrolimus DC4MCMW Mycophenolic acid Immunosuppression After Renal Transplantation [24]
Mycophenolic acid + Tacrolimus DCO9SR3 Mycophenolic acid Liver Transplantation [25]
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⏷ Show the Full List of 22 DrugCom(s)

References

1 Tacrolimus FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6784).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT03083782) Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus
5 ClinicalTrials.gov (NCT02145403) Phase 1/2 Study of Carfilzomib for the Prevention of Relapse and GVHD in Allo-HCT for Hematologic Malignancies
6 ClinicalTrials.gov (NCT00133887) TUMORAPA 1: Efficacy of Rapamycin in Secondary Prevention of Skin Cancers in Kidney Transplant Recipients
7 ClinicalTrials.gov (NCT00005113) A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
8 ClinicalTrials.gov (NCT01535547) Drug Interaction Study of Isavuconazole and Tacrolimus
9 ClinicalTrials.gov (NCT00406393) Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)
10 ClinicalTrials.gov (NCT01754389) Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell Transplant
11 ClinicalTrials.gov (NCT00117689) Evaluation of Thymoglobulin Induction and Reduced Doses of Calcineurin Inhibitors on Liver Transplant Rejection
12 ClinicalTrials.gov (NCT00089011) Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer
13 ClinicalTrials.gov (NCT01018914) A Study to Compare Safety and Efficacy of Prograf + Myfortic and Advagraf + Myfortic in Liver Transplantation Patients
14 ClinicalTrials.gov (NCT01473732) Mechanisms and Treatment of Chronic Allograft Injury (CAI) Due to Calcineurin Inhibitor (CNI) Toxicity
15 ClinicalTrials.gov (NCT01038167) A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
16 ClinicalTrials.gov (NCT05646992) Uterus Transplantation to Treat Infertility
17 ClinicalTrials.gov (NCT02877082) Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patients
18 ClinicalTrials.gov (NCT05621759) Cyclophosphamide, Abatacept, and Tacrolimus for the Prevention of GvHD
19 ClinicalTrials.gov (NCT05553496) Assessment of Rituximab Therapeutic Response Versus Conventional Treatment
20 ClinicalTrials.gov (NCT01878786) A Pilot Study Comparing the Safety and Efficacy of Everolimus With Other Medicines in Recipients of ECD/DCD Kidneys
21 ClinicalTrials.gov (NCT05694130) Tacrolimus Plus Glucocorticoid for Severe Thrombocytopenia in SS
22 ClinicalTrials.gov (NCT02115113) REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy
23 ClinicalTrials.gov (NCT05252754) Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis
24 ClinicalTrials.gov (NCT02453867) Efficacy and Safety of a Reduced Immunosuppression vs. Standard Triple Therapy in Senior Renal Transplant Recipients
25 ClinicalTrials.gov (NCT02123108) Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA (Enteric Coated Mycophenolic Acid) Following Liver Transplantation