Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3HIQY)

Drug Name
Melanoma vaccine (ALVAC) Drug Info
Synonyms Melanoma vaccine (ALVAC), sanofi pasteur; Melanoma vaccine (gp100/MAGE-1/MAGE-3/MART-1/NY-ESO-1, ALVAC), sanofi pasteur
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM3HIQY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cancer/testis antigen 1 (NY-ESO-1) TTE5ITK CTG1B_HUMAN Not Available [2]
MART-1 melanoma antigen (MLANA) TT362RB MAR1_HUMAN Not Available [2]
Melanocytes lineage-specific antigen GP100 (PMEL) TT8MK59 PMEL_HUMAN Not Available [2]
Melanoma-associated antigen 1 (MAGEA1) TT63M7Q MAGA1_HUMAN Not Available [2]
Melanoma-associated antigen 3 (MAGEA3) TTWSKHD MAGA3_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanoma-associated antigen 3 (MAGEA3) DTT MAGEA3 5.456 3.433 5.396 5.802
Melanocytes lineage-specific antigen GP100 (PMEL) DTT PMEL 5.885 5.225 6.079 5.959
Melanoma-associated antigen 1 (MAGEA1) DTT MAGEA1 1.433 1.536 2.138 2.848
MART-1 melanoma antigen (MLANA) DTT MLANA 5.361 5.115 4.926 4.954
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Skin
The Studied Disease Melanoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Melanocytes lineage-specific antigen GP100 (PMEL) DTT PMEL 1.08E-03 1.89 1.06
Melanoma-associated antigen 1 (MAGEA1) DTT MAGEA1 6.96E-12 0.59 1.39
MART-1 melanoma antigen (MLANA) DTT MLANA 3.29E-02 1.64 0.76
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014153)
2 Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58.