Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6VFO1)

Drug Name
Pregnenolone Drug Info
Synonyms Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Phase 4 [1]
Cross-matching ID
PubChem CID
8955
ChEBI ID
CHEBI:16581
CAS Number
CAS 145-13-1
TTD Drug ID
DM6VFO1
INTEDE Drug ID
DR1336

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Phase 4 [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DEN0GVQ 3BHS2_HUMAN Phase 4 [4]
Sulfotransferase 2A1 (SULT2A1) DE0P6LK ST2A1_HUMAN Phase 4 [5]
Dihydrotestosterone oxidoreductase (HSD3B1) DERDQWN 3BHS1_HUMAN Phase 4 [4]
Sulfotransferase 2B1 (SULT2B1) DEZBN53 ST2B1_HUMAN Phase 4 [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Estrogen-related receptor-alpha (ESRRA) DTT ESRRA 6.624 7.517 7.231 7.825
Sulfotransferase 2B1 (SULT2B1) DME SULT2B1 5.781 4.921 5.413 6.345
Dihydrotestosterone oxidoreductase (HSD3B1) DME HSD3B1 3.926 3.018 3.755 5.684
Beta-HSD adrenal and gonadal type (HSD3B2) DME HSD3B2 5.158 5.244 4.053 3.036
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 11.692 6.58 4.984 9.089
Sulfotransferase 2A1 (SULT2A1) DME SULT2A1 9.177 3.42 3.591 7.614
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 06 Mental, behavioural or neurodevelopmental disorder
Disease Class ICD-11: 6A20 Schizophrenia
The Studied Tissue Pre-frontal cortex
The Studied Disease Schizophrenia [ICD-11:6A20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Estrogen-related receptor-alpha (ESRRA) DTT ESRRA 9.34E-01 1.47E-02 0.06
Estrogen-related receptor-alpha (ESRRA) DTT ESRRA 2.09E-01 -0.07 -0.62
Sulfotransferase 2B1 (SULT2B1) DME SULT2B1 9.69E-01 3.48E-03 1.02E-02
Sulfotransferase 2B1 (SULT2B1) DME SULT2B1 8.40E-01 6.15E-02 3.66E-01
Dihydrotestosterone oxidoreductase (HSD3B1) DME HSD3B1 2.84E-01 -8.57E-03 -6.45E-02
Dihydrotestosterone oxidoreductase (HSD3B1) DME HSD3B1 7.78E-01 4.16E-03 5.82E-02
Beta-HSD adrenal and gonadal type (HSD3B2) DME HSD3B2 2.39E-01 5.15E-02 2.14E-01
Beta-HSD adrenal and gonadal type (HSD3B2) DME HSD3B2 8.14E-01 -2.28E-02 -1.48E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 4.66E-01 4.25E-02 1.20E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 4.75E-01 5.15E-02 3.64E-01
Sulfotransferase 2A1 (SULT2A1) DME SULT2A1 7.80E-01 -1.17E-03 -9.90E-03
Sulfotransferase 2A1 (SULT2A1) DME SULT2A1 1.01E-01 -1.06E-02 -1.31E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2376).
2 Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6.
3 Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos. 2008 Feb;36(2):435-41.
4 Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
5 Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9.