Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6VFO1)

Drug Name

Pregnenolone Drug Info

Synonyms

Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Phase 4	[1] , [2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen-related receptor-alpha (ESRRA)	TTPNQAC	ERR1_HUMAN	Agonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Phase 4	[4]
Beta-HSD adrenal and gonadal type (HSD3B2)	DEN0GVQ	3BHS2_HUMAN	Phase 4	[5]
Sulfotransferase 2A1 (SULT2A1)	DE0P6LK	ST2A1_HUMAN	Phase 4	[6]
Dihydrotestosterone oxidoreductase (HSD3B1)	DERDQWN	3BHS1_HUMAN	Phase 4	[5]
Sulfotransferase 2B1 (SULT2B1)	DEZBN53	ST2B1_HUMAN	Phase 4	[6]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Estrogen-related receptor-alpha (ESRRA)	DTT	ESRRA	6.624	7.517	7.231	7.825
Sulfotransferase 2B1 (SULT2B1)	DME	SULT2B1	5.781	4.921	5.413	6.345
Dihydrotestosterone oxidoreductase (HSD3B1)	DME	HSD3B1	3.926	3.018	3.755	5.684
Beta-HSD adrenal and gonadal type (HSD3B2)	DME	HSD3B2	5.158	5.244	4.053	3.036
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	11.692	6.58	4.984	9.089
Sulfotransferase 2A1 (SULT2A1)	DME	SULT2A1	9.177	3.42	3.591	7.614

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

06 Mental, behavioural or neurodevelopmental disorder

Disease Class

ICD-11: 6A20 Schizophrenia

The Studied Tissue

Pre-frontal cortex

The Studied Disease

Schizophrenia [ICD-11:6A20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Estrogen-related receptor-alpha (ESRRA)	DTT	ESRRA	9.34E-01	1.47E-02	0.06
Estrogen-related receptor-alpha (ESRRA)	DTT	ESRRA	2.09E-01	-0.07	-0.62
Sulfotransferase 2B1 (SULT2B1)	DME	SULT2B1	9.69E-01	3.48E-03	1.02E-02
Sulfotransferase 2B1 (SULT2B1)	DME	SULT2B1	8.40E-01	6.15E-02	3.66E-01
Dihydrotestosterone oxidoreductase (HSD3B1)	DME	HSD3B1	2.84E-01	-8.57E-03	-6.45E-02
Dihydrotestosterone oxidoreductase (HSD3B1)	DME	HSD3B1	7.78E-01	4.16E-03	5.82E-02
Beta-HSD adrenal and gonadal type (HSD3B2)	DME	HSD3B2	2.39E-01	5.15E-02	2.14E-01
Beta-HSD adrenal and gonadal type (HSD3B2)	DME	HSD3B2	8.14E-01	-2.28E-02	-1.48E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.66E-01	4.25E-02	1.20E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.75E-01	5.15E-02	3.64E-01
Sulfotransferase 2A1 (SULT2A1)	DME	SULT2A1	7.80E-01	-1.17E-03	-9.90E-03
Sulfotransferase 2A1 (SULT2A1)	DME	SULT2A1	1.01E-01	-1.06E-02	-1.31E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2376).
2	ClinicalTrials.gov (NCT01409096) Study Using Pregnenolone to Treat Bipolar Depression. U.S. National Institutes of Health.
3	Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6.
4	Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos. 2008 Feb;36(2):435-41.
5	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
6	Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9.