Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAHMSV)

Drug Name
Fucose Drug Info
Synonyms L-galactomethylose; 6-Desoxygalactose; SCHEMBL13092958; AKOS030212707
Cross-matching ID
PubChem CID
17106
ChEBI ID
CHEBI:2181
CAS Number
CAS 87-96-7
TTD Drug ID
DMAHMSV
VARIDT Drug ID
DR00198

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [1]
Alpha-galactosidase A (GLA) TTIS03D AGAL_HUMAN Inhibitor [1]
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Coagulation factor VII (F7) TTF0EGX FA7_HUMAN Inhibitor [1]
Complement C1s component (C1S) TT7LRQH C1S_HUMAN Inhibitor [1]
Cytotoxic T-lymphocyte protein 4 (CTLA-4) TTI2S1D CTLA4_HUMAN Inhibitor [1]
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Inhibitor [1]
E-selectin (SELE) TTAU4D6 LYAM2_HUMAN Inhibitor [1]
Immunoglobulin epsilon Fc receptor gamma (FCERG) TTDGEC0 FCERG_HUMAN Inhibitor [1]
Influenza Neuraminidase (Influ NA) TT50QJ3 NRAM_I33A0 Inhibitor [1]
Insulin-like growth factor I receptor (IGF1R) TTHRID2 IGF1R_HUMAN Inhibitor [1]
Lactase-phlorizin hydrolase (LCT) TTA0OSE LPH_HUMAN Inhibitor [1]
Lactotransferrin (LTF) TTSZDQU TRFL_HUMAN Inhibitor [1]
Membrane-associated lectin type-C (CD209) TTBXIM9 CD209_HUMAN Inhibitor [1]
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Inhibitor [1]
P-selectin (SELP) TTE5VG0 LYAM3_HUMAN Inhibitor [1]
Urokinase-type plasminogen activator (PLAU) TTGY7WI UROK_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Sodium/glucose cotransporter 1 (SLC5A1) DTOKC04 SC5A1_HUMAN Phase 1/2 [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neutrophil elastase (NE) DTT ELANE 2.379 2.036 1.379 2.945
Cytotoxic T-lymphocyte protein 4 (CTLA-4) DTT CTLA4 4.684 5.333 3.954 2.293
Insulin-like growth factor I receptor (IGF1R) DTT IGF1R 4.542 5.508 6.35 5.558
Urokinase-type plasminogen activator (PLAU) DTT PLAU 5.352 5.741 6.924 6.898
Coagulation factor VII (F7) DTT F7 9.218 4.853 5.6 5.747
P-selectin (SELP) DTT SELP 7.304 7.427 7.315 7.849
Dipeptidyl peptidase 4 (DPP-4) DTT DPP4 4.995 4.926 7.852 8.358
E-selectin (SELE) DTT SELE 5.194 3.307 3.104 5.907
Complement C1s component (C1S) DTT C1S 12.194 10.051 9.335 8.798
Acetylcholinesterase (AChE) DTT ACHE 1.678 1.926 1.766 5.252
Sodium/glucose cotransporter 1 (SLC5A1) DTP SGLT1 6.42 6.477 5.85 10.555
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neutrophil elastase (NE) DTT ELANE 1.68E-01 0.03 0.14
P-selectin (SELP) DTT SELP 1.72E-04 1.23 0.86
E-selectin (SELE) DTT SELE 2.05E-01 0.03 0.09
Sodium/glucose cotransporter 1 (SLC5A1) DTP SGLT1 1.61E-01 -1.75E-01 -2.67E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977.