Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCP2KH)

Drug Name

HE2100 Drug Info

Synonyms

Androstenediol; Hermaphrodiol; 5-Androstenediol; Androst-5-enediol; 521-17-5; Androst-5-ene-3beta,17beta-diol; Neumune; 3beta,17beta-Dihydroxyandrost-5-ene; delta(sup 5)-Androstenediol; Androstenediol [JAN]; UNII-95PS51EMXY; Androst-5-enediol (VAN); (3beta,17beta)-androst-5-ene-3,17-diol; 5-AED; 3beta,17beta-Dihydroxy-5-androstene; androst-5-en-3beta,17beta-diol; EINECS 208-306-8; NSC 12163; 95PS51EMXY; ANDROST-5-ENE-3-beta,17-beta-DIOL; CHEMBL440283; CHEBI:2710; (3-beta,17-beta)-Androst-5-ene-3,17-diol; delta(sup; ANDROSTENEDIOL

Indication

Disease Entry	ICD 11	Status	REF
Thrombocytopenia	3B64	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 10634
ChEBI ID: CHEBI:2710
CAS Number: CAS 521-17-5
TTD Drug ID: DMCP2KH
INTEDE Drug ID: DR0115

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Inhibitor	[2]
Estrogen receptor beta (ESR2)	TTOM3J0	ESR2_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Dihydrotestosterone oxidoreductase (HSD3B1)	DERDQWN	3BHS1_HUMAN	Discontinued	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Estrogen receptor (ESR)	DTT	ESR1	3.728	3.17	4.897	4.505
Estrogen receptor beta (ESR2)	DTT	ESR2	3.365	3.776	3.485	3.036
Dihydrotestosterone oxidoreductase (HSD3B1)	DME	HSD3B1	3.926	3.018	3.755	5.684

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Thrombocytopenia

ICD Disease Classification

3B64

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dihydrotestosterone oxidoreductase (HSD3B1)	DME	HSD3B1	6.74E-01	5.36E-02	4.46E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015080)
2	Androstene-3,5-dienes as ER-beta selective SERMs. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8.
3	Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.