Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD4BFY)

Drug Name
SPERMINE Drug Info
Synonyms
spermine; 71-44-3; neuridine; musculamine; gerontine; Spermin; 4,9-Diaza-1,12-dodecanediamine; Diaminopropyltetramethylenediamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Spermine, puriss; N,N'-Bis(3-aminopropyl)butane-1,4-diamine; 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-; 1,4-Bis(aminopropyl)butanediamine; 4,9-Diazadodecamethylenediamine; 4,9-Diazadodecane-1,12-diamine; N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine); UNII-2FZ7Y3VOQX; 1,4-Bis(aminopropyl) butanediamine; Spermine Derivative; 1,4-Diaminobutane, N,N'-bis
Cross-matching ID
PubChem CID
1103
ChEBI ID
CHEBI:15746
CAS Number
CAS 71-44-3
TTD Drug ID
DMD4BFY
VARIDT Drug ID
DR01249
INTEDE Drug ID
DR1505

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]
Carbonic anhydrase VI (CA-VI) TTCFSPE CAH6_HUMAN Inhibitor [1]
Carbonic anhydrase XIV (CA-XIV) TTEYTKG CAH14_HUMAN Inhibitor [1]
Glutamate receptor ionotropic NMDA 1 (NMDAR1) TTLD29N NMDZ1_HUMAN Inhibitor [2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) TTKJEMQ NMDE1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
MFS-type transporter SLC18B1 (SLC18B1) DTOFXP5 S18B1_HUMAN Preclinical [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Putrescine acetyltransferase (SSAT1) DEMWO83 SAT1_HUMAN Phase 1 [4]
Spermine oxidase (SMOX) DEOH5V3 SMOX_HUMAN Phase 1 [5]
Polyamine oxidase (PAOX) DEW7V0G PAOX_HUMAN Phase 1 [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutamate receptor ionotropic NMDA 1 (NMDAR1) DTT GRIN1 3.828 2.744 3.392 3.307
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DTT GRIN2A 5 5.446 5.459 3.35
Carbonic anhydrase XIV (CA-XIV) DTT CA14 6.263 6.538 6.531 6.293
Carbonic anhydrase VI (CA-VI) DTT CA6 3.678 5.784 5.19 5.717
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Polyamine oxidase (PAOX) DME PAOX 5.865 5.629 5.586 6.211
Spermine oxidase (SMOX) DME SMOX 2.678 4.066 4.343 3.916
Putrescine acetyltransferase (SSAT1) DME SAT1 9.514 9.189 9.868 9.085
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IV (CA-IV) DTT CA4 1.58E-77 -2.02 -1.77
Carbonic anhydrase XIV (CA-XIV) DTT CA14 5.79E-07 -0.09 -0.16
Carbonic anhydrase VI (CA-VI) DTT CA6 3.64E-10 -0.17 -0.37
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
MFS-type transporter SLC18B1 (SLC18B1) DTP SLC18B1 1.24E-09 -1.85E-01 -2.85E-01
Polyamine oxidase (PAOX) DME PAOX 1.25E-41 3.26E-01 1.01E+00
Spermine oxidase (SMOX) DME SMOX 1.04E-02 -6.80E-02 -2.31E-01
Putrescine acetyltransferase (SSAT1) DME SAT1 1.55E-45 6.17E-01 1.19E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
2 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7.
3 Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014 Oct 30;4:6836.
4 Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95.
5 Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection. Front Immunol. 2018 Jun 5;9:1242.
6 Polyamine catabolism and disease. Biochem J. 2009 Jul 15;421(3):323-38.